Traditional Chinese medicine composition for preparing Candida resisting medicines

A composition and Candida technology are applied in the direction of antifungal agents, medical preparations containing active ingredients, and pharmaceutical formulas, which can solve the problems of large usage of Tween 80, achieve good safety, improve antibacterial activity, The effect of a single formula

Active Publication Date: 2014-10-08
THE SECOND HOSPITAL OF HEBEI MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

And in many patents of traditional Chinese medicine preparations, Tween 80 is also widely used, such as the use of Tween 80 as an emulsifier in the patent CN1019821...

Method used

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  • Traditional Chinese medicine composition for preparing Candida resisting medicines
  • Traditional Chinese medicine composition for preparing Candida resisting medicines
  • Traditional Chinese medicine composition for preparing Candida resisting medicines

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Cinnamaldehyde: 1.25g (50 parts by weight),

[0042] Patchouli ketone: 1.25g (50 parts by weight).

Embodiment 2

[0044] Cinnamaldehyde: 1.25g (50 parts by weight),

[0045] Patchouli ketone: 1.25g (50 parts by weight),

[0046] Tween 80: 0.05g (2 parts by weight).

Embodiment 3

[0048] Cinnamaldehyde: 4.0g (80 parts by weight),

[0049]Patchouli ketone: 2.0g (40 parts by weight),

[0050] Tween 80: 0.05g (1 part by weight).

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Abstract

The invention relates to a traditional Chinese medicine composition for preparing Candida resisting medicines. The traditional Chinese medicine composition contains the ingredients in parts by weight: 40-80 parts of cinnamaldehyde and 30-60 parts of pogostone. The traditional Chinese medicine composition for preparing the Candida resisting medicines, provided by the invention, can be used for treating deep or systemic fungal infections caused by Candida, including deep or systemic fungal infections caused by Candida albicans, Candida tropicalis, Candida krusei or Candida glabrata. According to the traditional Chinese medicine composition, the pogostone is screened from numerous ingredients of ageratum oil, has relatively high bacteriostasis activity and has a good synergistic effect with the cinnamaldehyde; the cinnamaldehyde and the pogostone are suitable for being used after being combined; compared with the bacteriostasis activity after the cinnamaldehyde and the ageratum oil are combined, the bacteriostasis activity after the pogostone and the cinnamaldehyde are combined is remarkably improved, and the safety is good.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, which can be used for preparing medicines against candida infection. Background technique [0002] With the wide application of broad-spectrum antibiotics, corticosteroids and immunosuppressants, deep fungal infections have become more and more common in various clinical disciplines, and have become a serious complication of high-risk patients. , AIDS and other important factors of death. The first pathogenic bacterium is Candida, with a fatality rate of 30-60%, among which the mortality rate of Candida krusei infection is as high as 100%. At present, the treatment of deep fungal infection caused by Candida is multi-system chemical synthesis, such as fluconazole, itraconazole, caspofungin, voriconazole, etc. Although they have different degrees of antibacterial effects, they are all expensive and have serious side effects. specialty. Therefore, in order to discover high-efficiency ...

Claims

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Application Information

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IPC IPC(8): A61K31/366A61P31/10A61K31/11
Inventor 王刚生
Owner THE SECOND HOSPITAL OF HEBEI MEDICAL UNIV
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