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Composition containing bromhexine hydrochloride

A technology of bromhexine hydrochloride and a composition, which is applied in the field of compositions containing bromhexine hydrochloride, can solve the problems of large side effects, cumbersome methods, and many types of western medicines, and achieves the advantages of reducing side effects, excellent therapeutic effect, and reducing dosage. Effect

Active Publication Date: 2014-11-19
GUANGZHOU YIPINHONG PHARMA +4
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] 1. The curative effect of western medicine is fast, but there are many kinds of medicines and cumbersome methods used in comprehensive treatment at the same time, and many of them have serious side effects
[0005] 2. The method of taking traditional Chinese medicine is troublesome and the effect is slow

Method used

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  • Composition containing bromhexine hydrochloride
  • Composition containing bromhexine hydrochloride
  • Composition containing bromhexine hydrochloride

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] The moringa tree is washed with water, dried, pulverized, then mixed with bromhexine hydrochloride at a ratio of 1:1 by weight, and sterilized to obtain the pharmaceutical composition.

Embodiment 2

[0018] The moringa tree is washed with water, dried, pulverized, then mixed with bromhexine hydrochloride at a ratio of 1:3 by weight, and sterilized to obtain the pharmaceutical composition.

Embodiment 3

[0019] Embodiment 3: Activity experiment

[0020] The experimental results of the composition of Example 1 and bromhexine hydrochloride in treating asthma are shown in Tables 1-3.

[0021] The impact of table 1 on histamine spray-induced asthma (X±SD, n=6)

[0022]

[0023] The influence of table 2 on mouse isolated complete tracheal smooth muscle (X±SD, n=6)

[0024]

[0025] Table 3 the antitussive effect (X±SD) on mice induced by ammonia water

[0026]

[0027] Note: Compared with distilled water control group, *P<0.05, **P<0.01.

[0028] As can be seen from Tables 1-3, both the composition of Example 1 and bromhexine hydrochloride have a good therapeutic effect on asthma, and under the same dosage, the composition of Example 1 has a better therapeutic effect than bromhexine hydrochloride.

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Abstract

The invention discloses a composition containing bromhexine hydrochloride. The composition comprises the following components by weight: 1-3 parts of bromhexine hydrochloride and 1-3 parts of Moringa oleifera. The composition is prepared by washing Moringa oleifera with water, drying, crushing, and then mixing Moringa oleifera with bromhexine hydrochloride by a certain weight ratio, and sterilizing. Bromhexine hydrochloride has of good curative effect in the treatment of asthma; however, as a Western medicine, bromhexine hydrochloride inevitably has side effect, and in order to reduce the impact of side effects, the Moringa oleifera is added to bromhexine hydrochloride in the composition provided by the invention; and the obtained composition has significant effect on the treatment of asthma. Combination of bromhexine hydrochloride and Moringa oleifera has a synergistic therapeutic effects; in the same amount of dosage, the treatment effect of the composition is better than that of bromhexine hydrochloride, so as to greatly reduce the amount of bromhexine hydrochloride and reduce the side effects caused by bromhexine hydrochloride.

Description

technical field [0001] The invention relates to a composition containing bromhexine hydrochloride. Background technique [0002] Bronchial asthma (asthma for short) is pathological changes such as bronchial smooth muscle spasm, mucosal edema, and increased mucus secretion caused by sensitizing factors or non-sensitizing factors acting on the body. It is composed of various cells, especially eosinophils (EOS), Inflammatory cells such as mast cells, T lymphocytes, neutrophils (NEUT) and airway epithelial cells and their various cellular components participate in chronic airway allergic inflammation, which can occur in people of different age groups. Respiratory disease with high morbidity and mortality. The pathogenesis of asthma is complex, and most of them are stimulated by certain factors inside and outside the body on the basis of heredity. [0003] There are following deficiencies in the existing asthma comprehensive treatment technology: [0004] 1. The curative effec...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61P11/06A61K31/137
Inventor 李捍雄
Owner GUANGZHOU YIPINHONG PHARMA
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