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Mesosulide gel and its preparation method and use

A methosulide gel, a technology for preparing medicines, applied in the directions of anti-inflammatory agents, aerosol delivery, non-central analgesics, etc. The use of topical preparations needs to be strengthened to achieve the effect of good curative effect, good anti-inflammatory effect, and improvement of pain threshold

Inactive Publication Date: 2017-02-22
WUHAN OPTICS VALLEY HUMANWELL BIO PHARMA +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is currently no research report on mesosulide topical preparations
[0004] Therefore, research on topical preparations of mesosulide still needs to be strengthened

Method used

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  • Mesosulide gel and its preparation method and use
  • Mesosulide gel and its preparation method and use

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Example 1. Preparation of Mesosulide Gel

[0035] prescription:

[0036] Mesocilol 25g, tromethamine 10g, carbomer 25g, glycerol 20g, propylene glycol 80g, ethylenediaminetetraacetic acid disodium 0.05g, ethyl paraben 1g, borneol 25g, camphor 10g, volume concentration 95 % Ethanol 180g and water 400g.

[0037] Preparation:

[0038] (1) Dissolve the disodium ethylenediaminetetraacetic acid with a part of water, then add the carbomer, stir evenly, and let stand to obtain the carbomer gel containing disodium ethylenediaminetetraacetic acid, which is recorded as mixed solution 1 ,spare;

[0039] (2) Micronize Mesosuride to a particle size of 30-60 microns, stir and disperse in ethanol, and then add tromethamine aqueous solution and stir to dissolve to obtain mixed solution 2 for use;

[0040] (3) Add glycerin, propylene glycol, ethyl paraben, borneol, camphor and mixture 2 to ethanol with a volume concentration of 95%, stir evenly to obtain mixture 3, and then mix mixture 3 with mix...

Embodiment 2

[0041] Example 2. Preparation of Mesocilol Gel

[0042] prescription:

[0043] Mesocilide 50g, Tromethamine 50g, Carbomer 50g, Glycerin 30g, Propylene Glycol 150g, Disodium EDTA 0.1g, Ethyl Paraben 1g, Borneol 30g, Camphor 12g, Volume Concentration is 95 % Ethanol 360g and water 500g.

[0044] Preparation:

[0045] (1) Dissolve the disodium ethylenediaminetetraacetic acid with a part of water, then add the carbomer, stir evenly, and let stand to obtain the carbomer gel containing disodium ethylenediaminetetraacetic acid, which is recorded as mixed solution 1 ,spare;

[0046] (2) Micronize Mesocilol to a particle size of 1-30 microns, stir and disperse in ethanol, and then add tromethamine aqueous solution and stir to dissolve to obtain mixture 2 for use;

[0047] (3) Add glycerin, propylene glycol, ethyl paraben, borneol, camphor and mixed liquid 2 to 95% ethanol by volume and stir evenly to obtain mixed liquid 3, and then mix mixed liquid 3 with mixed liquid 1. , Add the remaining wa...

Embodiment 3

[0048] Example 3. Preparation of Mesocilol Gel

[0049] prescription:

[0050] Mesocilide 100g, tromethamine 40g, carbomer 80g, glycerol 40g, propylene glycol 120g, ethylenediaminetetraacetic acid disodium 0.15g, ethyl paraben 1.5g, borneol 40g, camphor 12g, volume concentration is 300 g of 95% ethanol and 700 g of water.

[0051] Preparation:

[0052] (1) Dissolve the disodium ethylenediaminetetraacetic acid with a part of water, then add the carbomer, stir evenly, and let stand to obtain the carbomer gel containing disodium ethylenediaminetetraacetic acid, which is recorded as mixed solution 1 ,spare;

[0053] (2) Micronize Mesosuride to a particle size of 60-100 microns, stir and disperse in ethanol, and then add tromethamine aqueous solution and stir to dissolve to obtain mixed solution 2 for use;

[0054] (3) Add glycerin, propylene glycol, ethyl paraben, borneol, camphor and mixture 2 to ethanol with a volume concentration of 95%, stir evenly to obtain mixture 3, and then mix mix...

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Abstract

The invention provides a mesosulide gel, a preparation method and application thereof. The mesosulide gel comprises: mesosulide; and pharmaceutically acceptable auxiliary materials. Methosulide gel of the present invention can be effectively used in the treatment of local pain, inflammation, rheumatoid arthritis, osteoarthritis, and acute soft tissue injury, and can effectively solve the problem of low curative effect, large side effects and high price of existing drugs. The problem of low transdermal absorption rate.

Description

Technical field [0001] The present invention relates to the technical field of pharmacy, in particular to a mesocilline gel and its preparation method and application. Background technique [0002] Mesocilol is the world's first class 1.1 chemical drug developed by the Academy of Military Medical Sciences and Renfu Pharmaceutical Group. Mesocilol is a non-steroidal anti-inflammatory drug (NSAID for short). The main mechanism of action is to inhibit the activity of cyclooxygenase (COX-2), thereby inhibiting the final production of arachidonic acid into prostacyclin (PGⅡ), prostate (PGE1, PGE2) and hemagglutinin A2 (TXA2), which reduce the synthesis of prostaglandins, hemagglutinin and other inflammatory mediators, so it has good antipyretic, analgesic, anti-inflammatory, and swelling effects . [0003] It is of great significance to develop a topical preparation of mesocilide with good curative effect and small side effects for antipyretic, analgesic, anti-inflammatory and swellin...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/06A61K31/18A61P29/00
Inventor 李莉娥王学海许勇廖娟娟黄怡黄璐涂荣华杨仲文乐洋江曦朱垒余艳平刘荃王伟田华肖强范昭泽杨菁张毅
Owner WUHAN OPTICS VALLEY HUMANWELL BIO PHARMA
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