Mesosulide gel and its preparation method and use
A methosulide gel, a technology for preparing medicines, applied in the directions of anti-inflammatory agents, aerosol delivery, non-central analgesics, etc. The use of topical preparations needs to be strengthened to achieve the effect of good curative effect, good anti-inflammatory effect, and improvement of pain threshold
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Embodiment 1
[0034] Example 1. Preparation of Mesosulide Gel
[0035] prescription:
[0036] Mesocilol 25g, tromethamine 10g, carbomer 25g, glycerol 20g, propylene glycol 80g, ethylenediaminetetraacetic acid disodium 0.05g, ethyl paraben 1g, borneol 25g, camphor 10g, volume concentration 95 % Ethanol 180g and water 400g.
[0037] Preparation:
[0038] (1) Dissolve the disodium ethylenediaminetetraacetic acid with a part of water, then add the carbomer, stir evenly, and let stand to obtain the carbomer gel containing disodium ethylenediaminetetraacetic acid, which is recorded as mixed solution 1 ,spare;
[0039] (2) Micronize Mesosuride to a particle size of 30-60 microns, stir and disperse in ethanol, and then add tromethamine aqueous solution and stir to dissolve to obtain mixed solution 2 for use;
[0040] (3) Add glycerin, propylene glycol, ethyl paraben, borneol, camphor and mixture 2 to ethanol with a volume concentration of 95%, stir evenly to obtain mixture 3, and then mix mixture 3 with mix...
Embodiment 2
[0041] Example 2. Preparation of Mesocilol Gel
[0042] prescription:
[0043] Mesocilide 50g, Tromethamine 50g, Carbomer 50g, Glycerin 30g, Propylene Glycol 150g, Disodium EDTA 0.1g, Ethyl Paraben 1g, Borneol 30g, Camphor 12g, Volume Concentration is 95 % Ethanol 360g and water 500g.
[0044] Preparation:
[0045] (1) Dissolve the disodium ethylenediaminetetraacetic acid with a part of water, then add the carbomer, stir evenly, and let stand to obtain the carbomer gel containing disodium ethylenediaminetetraacetic acid, which is recorded as mixed solution 1 ,spare;
[0046] (2) Micronize Mesocilol to a particle size of 1-30 microns, stir and disperse in ethanol, and then add tromethamine aqueous solution and stir to dissolve to obtain mixture 2 for use;
[0047] (3) Add glycerin, propylene glycol, ethyl paraben, borneol, camphor and mixed liquid 2 to 95% ethanol by volume and stir evenly to obtain mixed liquid 3, and then mix mixed liquid 3 with mixed liquid 1. , Add the remaining wa...
Embodiment 3
[0048] Example 3. Preparation of Mesocilol Gel
[0049] prescription:
[0050] Mesocilide 100g, tromethamine 40g, carbomer 80g, glycerol 40g, propylene glycol 120g, ethylenediaminetetraacetic acid disodium 0.15g, ethyl paraben 1.5g, borneol 40g, camphor 12g, volume concentration is 300 g of 95% ethanol and 700 g of water.
[0051] Preparation:
[0052] (1) Dissolve the disodium ethylenediaminetetraacetic acid with a part of water, then add the carbomer, stir evenly, and let stand to obtain the carbomer gel containing disodium ethylenediaminetetraacetic acid, which is recorded as mixed solution 1 ,spare;
[0053] (2) Micronize Mesosuride to a particle size of 60-100 microns, stir and disperse in ethanol, and then add tromethamine aqueous solution and stir to dissolve to obtain mixed solution 2 for use;
[0054] (3) Add glycerin, propylene glycol, ethyl paraben, borneol, camphor and mixture 2 to ethanol with a volume concentration of 95%, stir evenly to obtain mixture 3, and then mix mix...
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