Method for preparing physochlaina-macrophylla water-binder pill

Abstract

The invention discloses a method for preparing a physochlaina-macrophylla water-binder pill. The method comprises the following steps: (1) smashing physochlaina macrophylla into coarse powder, extracting the coarse powder for 1-3 times by using a 70-95% (by volume) aqueous solution of ethanol through fluxing, combining extracts, filtering, recovering ethanol in a filtrate, and concentrating the extract at the temperature of 65-80 DEG C until the relative density is 1.03-1.3 to obtain a concentrated paste, wherein the aqueous solution of ethanol is 4-10 times the mass of the physochlaina macrophylla, and each time of extracting lasts for 1-4 hours; and (2) diluting the concentrated paste with purified water, adding aqueous ammonia, alkalifying the concentrated paste until the pH value is 8-11 to obtain alkalified diluted liquor, extracting the alkalified diluted liquor for 2-4 times to obtain an extract, recovering trichloromethane, volatilizing the extract by water bath until the extract is free from the smell of the trichloromethane to obtain a physochlaina-macrophylla extract, drying the physochlaina-macrophylla extract, smashing the physochlaina-macrophylla extract, feeding the smashed physochlaina-macrophylla extract into a pilling machine, and pilling to obtain the physochlaina-macrophylla water-binder pill, wherein the mass ratio of the concentrated paste to the purified water is 1:(0.8-1.5), and the trichloromethane is 0.5-3 times the volume of the alkalified diluted liquor. Experiments show that the physochlaina-macrophylla water-binder pill prepared by adopting the method disclosed by the invention has a good effect of relieving asthma.

Description

technical field

[0001] The invention belongs to the field of modern pharmaceuticals of traditional Chinese medicines, in particular to a preparation method of Huashan Shenshui pills. Background technique

[0002] Asthma is a widespread and reversible airway narrowing disease caused by bronchial hyperresponsiveness caused by allergens or other factors. The clinical manifestations are recurrent chest tightness, wheezing, dyspnea, cough and other symptoms. Before the attack, there are often aura symptoms such as nasal congestion, sneezing, and itchy eyes. In severe cases, severe dyspnea and hypoxemia may occur within a short period of time, threatening life. There are about 2000-3000 deaths from asthma in the United States every year, and there is an increasing trend. In 2004, the Global Initiative for Asthma Prevention (GINA) estimated that there were about 300 million cases in the world, the prevalence of asthma in children and adults was about 3.3%-29% and 1.2%-25.5%, resp...

Examples

Embodiment 1

[0015] A preparation method of Huashan Ginseng Water Pills, comprising the steps of:

[0016] (1) Take Huashan ginseng and grind it into a coarse powder, use 85% ethanol aqueous solution with a volume percentage concentration of 7 mass times to reflux extract twice, each time for 3 hours, combine the extracts, filter, recover ethanol from the filtrate, and concentrate to 75°C The relative density is 1.2, and the concentrated paste is obtained;

[0017] (2) Dilute the concentrated ointment with purified water at a mass ratio of 1:1, add ammonia water to make it alkaline to pH=9, obtain an alkalized dilution, extract 3 times with chloroform that is twice the volume of the alkalized dilution Once, the extract is obtained, the chloroform is recovered, and the chloroform is evaporated in a water bath until there is no smell of chloroform, and the Huashan ginseng extract is obtained, dried, crushed, put into a pellet machine, and pressed into Huashan ginseng water pills.

Embodiment 2

[0019] A preparation method of Huashan Ginseng Water Pills, comprising the steps of:

[0020] (1) Take Huashan ginseng and grind it into a coarse powder, use 4 times the volume percentage concentration of 95% ethanol aqueous solution to reflux extract once, extract for 4 hours, filter the extract, reclaim ethanol from the filtrate, and concentrate to a relative density of 65 ° C. 1.03 to obtain a concentrated ointment; (2) dilute the concentrated ointment with purified water at a mass ratio of 1:0.8, add ammonia water to make pH = 8, and obtain an alkalized dilution, which is 0.5 times the volume of the alkalized dilution The chloroform was extracted 4 times to obtain the extract, the chloroform was recovered, and the chloroform was evaporated in a water bath until there was no smell of chloroform, and the Huashan ginseng extract was obtained, dried, crushed, put into a pellet machine, and pressed into Huashan ginseng water pills.

Embodiment 3

[0022] A preparation method of Huashan Ginseng Water Pills, comprising the steps of:

[0023] (1) Take Huashan ginseng and grind it into a coarse powder, use 10 times by mass of 70% ethanol aqueous solution to reflux extract 3 times, each time for 1 hour, combine the extracts, filter, recover ethanol from the filtrate, and concentrate to 80 °C The relative density is 1.3, and the concentrated paste is obtained;

[0024] (2) According to the ratio of 1:1.5 in mass ratio, dilute the concentrated paste with purified water, add ammonia water to alkalinize to make pH=11, obtain alkalized dilution, extract 2 times with chloroform of alkalized dilution volume 3 times Once, the extract is obtained, the chloroform is recovered, and the chloroform is evaporated in a water bath until there is no smell of chloroform, and the Huashan ginseng extract is obtained, dried, crushed, put into a pellet machine, and pressed into Huashan ginseng water pills.

technical field

[0001] The invention belongs to the field of modern pharmaceuticals of traditional Chinese medicines, in particular to a preparation method of Huashan Shenshui pills. Background technique

[0002] Asthma is a widespread and reversible airway narrowing disease caused by bronchial hyperresponsiveness caused by allergens or other factors. The clinical manifestations are recurrent chest tightness, wheezing, dyspnea, cough and other symptoms. Before the attack, there are often aura symptoms such as nasal congestion, sneezing, and itchy eyes. In severe cases, severe dyspnea and hypoxemia may occur within a short period of time, threatening life. There are about 2000-3000 deaths from asthma in the United States every year, and there is an increasing trend. In 2004, the Global Initiative for Asthma Prevention (GINA) estimated that there were about 300 million cases in the world, the prevalence of asthma in children and adults was about 3.3%-29% and 1.2%-25.5%, resp...

Examples

Embodiment 1

[0015] A preparation method of Huashan Ginseng Water Pills, comprising the steps of:

[0016] (1) Take Huashan ginseng and grind it into a coarse powder, use 85% ethanol aqueous solution with a volume percentage concentration of 7 mass times to reflux extract twice, each time for 3 hours, combine the extracts, filter, recover ethanol from the filtrate, and concentrate to 75°C The relative density is 1.2, and the concentrated paste is obtained;

[0017] (2) Dilute the concentrated ointment with purified water at a mass ratio of 1:1, add ammonia water to make it alkaline to pH=9, obtain an alkalized dilution, extract 3 times with chloroform that is twice the volume of the alkalized dilution Once, the extract is obtained, the chloroform is recovered, and the chloroform is evaporated in a water bath until there is no smell of chloroform, and the Huashan ginseng extract is obtained, dried, crushed, put into a pellet machine, and pressed into Huashan ginseng water pills.

Embodiment 2

[0019] A preparation method of Huashan Ginseng Water Pills, comprising the steps of:

[0020] (1) Take Huashan ginseng and grind it into a coarse powder, use 4 times the volume percentage concentration of 95% ethanol aqueous solution to reflux extract once, extract for 4 hours, filter the extract, reclaim ethanol from the filtrate, and concentrate to a relative density of 65 ° C. 1.03 to obtain a concentrated ointment; (2) dilute the concentrated ointment with purified water at a mass ratio of 1:0.8, add ammonia water to make pH = 8, and obtain an alkalized dilution, which is 0.5 times the volume of the alkalized dilution The chloroform was extracted 4 times to obtain the extract, the chloroform was recovered, and the chloroform was evaporated in a water bath until there was no smell of chloroform, and the Huashan ginseng extract was obtained, dried, crushed, put into a pellet machine, and pressed into Huashan ginseng water pills.

Embodiment 3

[0022] A preparation method of Huashan Ginseng Water Pills, comprising the steps of:

[0023] (1) Take Huashan ginseng and grind it into a coarse powder, use 10 times by mass of 70% ethanol aqueous solution to reflux extract 3 times, each time for 1 hour, combine the extracts, filter, recover ethanol from the filtrate, and concentrate to 80 °C The relative density is 1.3, and the concentrated paste is obtained;

[0024] (2) According to the ratio of 1:1.5 in mass ratio, dilute the concentrated paste with purified water, add ammonia water to alkalinize to make pH=11, obtain alkalized dilution, extract 2 times with chloroform of alkalized dilution volume 3 times Once, the extract is obtained, the chloroform is recovered, and the chloroform is evaporated in a water bath until there is no smell of chloroform, and the Huashan ginseng extract is obtained, dried, crushed, put into a pellet machine, and pressed into Huashan ginseng water pills.

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