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Vitex oil nanoemulsion and preparation method thereof

A technology of nano-emulsion and Vitex oil, applied in the field of medicine, can solve the problems of air, light and temperature sensitivity, low absorption rate of the body, easy oxidative decomposition and deterioration, etc., to solve stability problems, good biocompatibility, improve The effect of compliance

Inactive Publication Date: 2010-07-14
江苏吴中苏药医药开发有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional heating method makes the bioactive ingredients easily destroyed, the taste is not good and the dosage is large, the absorption rate of the body is low, and it is difficult to give full play to its efficacy
Especially liquid oily traditional Chinese medicine, including traditional Chinese medicine unsaturated fatty oil and volatile oil, usually has strong physiological activity, but is sensitive to air, light and temperature, and is easy to oxidize, decompose and deteriorate

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0024] Vitex oil 20g

[0025] Medium Chain Fatty Acid Triglycerides 200g

[0026] Soy Lecithin PRS95 10g

[0027] Poloxamer 188 40g

[0028] Vitamin E 2g

[0029] Oleic acid 2.5g

[0030] Sorbic acid 1g

[0031] Ethanol 100g

[0032] Menthol 5g

[0033] Povidone K30 1g

[0034]

[0035] Add purified water to 1000ml

example 2

[0037] Vitex oil 20g

[0038] Medium Chain Fatty Acid Triglycerides 200g

[0039] Soy Lecithin PRS95 10g

[0040] Poloxamer 188 40g

[0041] Vitamin E 2g

[0042] Oleic acid 2.5g

[0043] Sorbic acid 1g

[0044] Ethanol 100g

[0045] Menthol 5g

[0046] Povidone K30 5g

[0047]

[0048] Add purified water to 1000ml

example 3

[0050] Vitex oil 20g

[0051] Medium Chain Fatty Acid Glycerides 200g

[0052] Soy Lecithin PRS95 10g

[0053] Poloxamer 188 40g

[0054] Vitamin E 2g

[0055] Oleic acid 2.5g

[0056] Sorbic acid 1g

[0057] Ethanol 150g

[0058] Menthol 5g

[0059] Povidone K30 1g

[0060]

[0061] Add purified water to 1000ml

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Abstract

The invention relates to a vitex oil nanoemulsion and a preparation method and application thereof. The preparation method is characterized in that the advanced nanotechnology is used for the formula and process design of the vitex oil nanoemulsion. The preparation method comprises the steps that: vitex oil, medium chain fatty acid triglyceride, soy lecithin, ethanol and the like are evenly mixed to be used as an oil phase; poloxamer is mixed with water and the like to be used as a water phase; the oil phase is added to the water phase to be mixed and emulsified at a temperature of 40 to 60 DEG C and be treated by a two-step high-pressure homogenizer to obtain the milk-white vitex oil nanoemulsion with the average particle size of less than 100nm. The vitex oil nanoemulsion prepared by the invention has high quality, reliable quality stability and good biocompatibility, and simultaneously has good expectorant, antitussive and antiasthmatic effects.

Description

technical field [0001] The invention relates to a vitex oil nanoemulsion and its preparation method and application, belonging to the technical field of medicine. Background technique [0002] Traditional Chinese medicine is a treasure of Chinese traditional culture. It has a long history of thousands of years in our country. Its unique medicinal effects play a decisive role in the world medical circle. The dosage forms of traditional Chinese medicine preparations are mostly decoctions, pills, granules, powders, etc. The traditional heating method makes the bioactive ingredients easily destroyed, the taste is not good, the dosage is large, the absorption rate of the body is low, and it is difficult to give full play to its efficacy. Especially liquid oily traditional Chinese medicine, including traditional Chinese medicine unsaturated fatty oil and volatile oil, usually has strong physiological activity, but is sensitive to air, light and temperature, and is easy to oxidize...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/85A61K9/107A61K47/34A61P11/06A61P11/10A61P11/14A61K127/00A61K47/10A61K47/32
Inventor 曹庆先祁小乐杨南林徐凌燕
Owner 江苏吴中苏药医药开发有限责任公司
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