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Preparation method for asthma-relieving radix physochlainae dropping pills

A dripping pill and anti-asthmatic technology, which is applied in the field of preparation of Huashan ginseng anti-asthmatic dripping pills, can solve the problems of large side effects, complicated pathogenesis and the like, and achieve the effect of good anti-asthmatic effect.

Inactive Publication Date: 2015-03-11
津药达仁堂集团股份有限公司第六中药厂
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The pathogenesis of the disease is very complicated, and there are various inducing factors. Western medicine mainly treats it with antibiotics, hormone drugs, β2 receptor stimulants, etc., with relatively large side effects.

Method used

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  • Preparation method for asthma-relieving radix physochlainae dropping pills
  • Preparation method for asthma-relieving radix physochlainae dropping pills

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] A preparation method of Huashan ginseng antiasthma dripping pills, comprising the steps of:

[0019] (1) Take Huashan ginseng and grind it into a coarse powder, use 7 mass times the volume percentage concentration of 85% ethanol aqueous solution to reflux extract twice, each time for 2 hours, combine the extracts, filter, recover ethanol from the filtrate, and concentrate to 70 °C The relative density is 1.2, and the concentrated paste is obtained;

[0020] (2) Dilute the concentrated ointment with purified water according to the mass ratio of 1:1, add ammonia water to alkalinize the pH=9, obtain an alkalized dilution, extract 3 times with ethyl acetate of 2 times the volume of the alkalized dilution times, to obtain the extract, reclaim the ethyl acetate, and evaporate it in a water bath until there is no ethyl acetate smell to obtain the Huashan ginseng extract;

[0021] (3) Weigh PEG6000 and heat to melt, add 1 part by mass of Huashan ginseng extract to 10 parts by ...

Embodiment 2

[0023] A preparation method of Huashan ginseng antiasthma dripping pills, comprising the steps of:

[0024] (1) Take Huashan ginseng and grind it into a coarse powder, use 4 mass times the volume percentage concentration of 95% ethanol aqueous solution to reflux extract 3 times, each time for 1 hour, combine the extracts, filter, recover ethanol from the filtrate, and concentrate to 80 ° C The relative density is 1.3, and the concentrated paste is obtained;

[0025] (2) Dilute the concentrated ointment with purified water at a ratio of 1:0.8 by mass, add ammonia water to make it alkaline to pH=11, obtain an alkalized dilution, and extract 3 times with ethyl acetate of three times the volume of the alkalized dilution times, to obtain the extract, reclaim the ethyl acetate, and evaporate it in a water bath until there is no ethyl acetate smell to obtain the Huashan ginseng extract;

[0026] (3) Weigh PEG6000 and heat to melt, add 1 mass part of Huashan ginseng extract to 6 part...

Embodiment 3

[0028] A preparation method of Huashan ginseng antiasthma dripping pills, comprising the steps of:

[0029] (1) Take Huashan ginseng and grind it into coarse powder, use 10 times by mass of 70% ethanol aqueous solution to reflux extract once, extract for 4 hours, filter the extract, reclaim ethanol from the filtrate, and concentrate to a relative density of 65°C. 1.03, get concentrated cream;

[0030] (2) According to the ratio of 1:1.5 in mass ratio, dilute the concentrated ointment with purified water, add ammonia water to basify to make pH=8, obtain basified diluent, extract 4 with ethyl acetate of 0.5 times the volume of basified diluent times, to obtain the extract, reclaim the ethyl acetate, and evaporate it in a water bath until there is no ethyl acetate smell to obtain the Huashan ginseng extract;

[0031] (3) Weigh PEG6000 and heat to melt, add 1 part by mass of Huashan ginseng extract to 14 parts by mass of melted PEG6000, stir evenly, put it into a drop pill storag...

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Abstract

The invention discloses a preparation method for asthma-relieving radix physochlainae dropping pills. The method comprises the following steps: (1) grinding radix physochlainae into coarse powder, performing reflux extraction by an ethanol aqueous solution, filtering extract liquid, recovering ethanol from filter liquor, and concentrating to obtain concentrated paste; (2) diluting the concentrated paste by purified water according to a mass ratio of 1 to (0.8-1.5), adding ammonia water for alkalizing to adjust the pH value to be 8-11 to obtain alkalized dilute liquid, extracting for 2-4 times by ethyl acetate with the volume being 0.5-3 times that of the alkalized dilute liquid to obtain extract liquor, recovering ethyl acetate, and volatilizing in a water bath until no ethyl acetate smell is generated to obtain radix physochlainae extract; weighing PEG 6,000 (polyethylene glycol 6,000) heating for melting, adding 1 part by mass of the radix physochlainae extract into 6-14 parts by mass of molten PEG 6,000, uniformly stirring, and dropping in a dropping pill storage tank to obtain the asthma-relieving radix physochlainae dropping pills. The asthma-relieving radix physochlainae dropping pills prepared by the method have a good asthma-relieving effect.

Description

technical field [0001] The invention belongs to the field of modernized traditional Chinese medicine pharmacy, and in particular relates to a preparation method of Huashan ginseng Pingchuan dripping pills. Background technique [0002] Asthma is a widespread and reversible airway narrowing disease caused by bronchial hyperresponsiveness caused by allergens or other factors. The clinical manifestations are recurrent chest tightness, wheezing, dyspnea, cough and other symptoms. Before the attack, there are often aura symptoms such as nasal congestion, sneezing, and itchy eyes. In severe cases, severe dyspnea and hypoxemia may occur within a short period of time, threatening life. There are about 2000-3000 deaths from asthma in the United States every year, and there is an increasing trend. In 2004, the Global Initiative for Asthma Prevention (GINA) estimated that there were about 300 million cases in the world, the prevalence of asthma in children and adults was about 3.3%-2...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/81A61K9/20A61P11/06
CPCA61K9/2031A61K36/81A61K2236/333A61K2236/39A61K2236/51
Inventor 刘丹佟永领王金磊刘梦妮
Owner 津药达仁堂集团股份有限公司第六中药厂
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