Preparation method of radix physochlainae granules

A technology of granules and concentrated ointment, which is applied in the field of preparation of Huashan ginseng granules, can solve the problems of large side effects and complicated pathogenesis, and achieve the effects of quick onset, remarkable curative effect and convenient administration

Inactive Publication Date: 2015-03-04
津药达仁堂集团股份有限公司第六中药厂
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The pathogenesis of the disease is very complicated, and there are various inducing factors. Western medicine mainly treats it with antibiotics, hormone drugs, β2 receptor stimulants, etc., with relatively large side effects.

Method used

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  • Preparation method of radix physochlainae granules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] A preparation method of Huashan ginseng granules, comprising the steps of:

[0017] (1) Take Huashan ginseng and grind it into a coarse powder, use 7 mass times the volume percentage concentration of 85% ethanol aqueous solution to reflux extract twice, each time for 2 hours, combine the extracts, filter, recover ethanol from the filtrate, and concentrate to 70 °C The relative density is 1.2, and the concentrated paste is obtained;

[0018] (2) Dilute the concentrated ointment with purified water at a mass ratio of 1:1, add ammonia water to make it alkaline to pH=9, obtain an alkalized dilution, extract 3 times with chloroform that is twice the volume of the alkalized dilution Once, the extract was obtained, the chloroform was reclaimed, and the ginseng extract was obtained by evaporating in a water bath until there was no chloroform smell;

[0019] (3) adding sucrose with 3 times the weight of the Huashan ginseng extract, mixing evenly, granulating, and drying to obta...

Embodiment 2

[0021] A preparation method of Huashan ginseng granules, comprising the steps of:

[0022] (1) Take Huashan ginseng and grind it into a coarse powder, use 4 mass times the volume percentage concentration of 95% ethanol aqueous solution to reflux extract 3 times, each time for 1 hour, combine the extracts, filter, recover ethanol from the filtrate, and concentrate to 80 ° C The relative density is 1.3, and the concentrated paste is obtained;

[0023] (2) According to the ratio of 1:0.8 in mass ratio, dilute the concentrated ointment with purified water, add ammonia water to alkalinize to make pH=11, obtain alkalized diluent, extract 3 times with chloroform of alkalized diluent volume 3 times Once, the extract was obtained, the chloroform was reclaimed, and the ginseng extract was obtained by evaporating in a water bath until there was no chloroform smell;

[0024] (3) Add starch with 5 times the mass of the Huashan ginseng extract, mix evenly, granulate, and dry to obtain.

Embodiment 3

[0026] A preparation method of Huashan ginseng granules, comprising the steps of:

[0027] (1) Take Huashan ginseng and grind it into coarse powder, use 10 times by mass of 70% ethanol aqueous solution to reflux extract once, extract for 4 hours, filter the extract, reclaim ethanol from the filtrate, and concentrate to a relative density of 65°C. 1.03, get concentrated cream;

[0028] (2) Dilute the concentrated ointment with purified water at a ratio of 1:1.5 by mass, add ammonia water to make it alkaline to make pH=8, obtain an alkalized dilution, extract 4 with chloroform of 0.5 times the volume of the alkalized dilution Once, the extract was obtained, the chloroform was reclaimed, and the ginseng extract was obtained by evaporating in a water bath until there was no chloroform smell;

[0029] (3) Add dextrin with 1 times the mass of the Huashan ginseng extract, mix evenly, granulate, and dry to obtain.

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Abstract

The invention discloses a preparation method of radix physochlainae granules. The preparation method comprises the following steps of (1) grinding radix physochlainae to form coarse powder, carrying out reflux extraction by using an ethanol water solution to obtain an extracting solution, filtering, recovering ethanol from filtrate, and concentrating to obtain a concentrated paste; (2) diluting the concentrated paste by using purified water at a mass ratio of 1:(0.8-1.5), adding ammonia water to alkalify until pH=8-11 so as to obtain an alkalified diluent, extracting for 2-4 times by using trichloromethane with the volume being 0.5-3 times as much as that of the alkalified diluent to obtain an extracting solution, recovering trichloromethane, and volatilizing a water bath until no trichloromethane smell exists to obtain a radix physochlainae extractive; and (3) adding saccharose, starch or dextrin, uniformly mixing, granulating and drying to obtain the radix physochlainae granules. Experiments prove that the radix physochlainae granules prepared by using the preparation method disclosed by the invention have a favorable asthma relieving effect. The radix physochlainae granules are rapid in effect taking, convenient to take, remarkable in curative effect and capable of simultaneously treating both symptoms and root causes of diseases, so that the demands of extensive patients can be met. By using the preparation method, few labor hours are needed, and the transfer rate of effective components is high.

Description

technical field [0001] The invention belongs to the field of modernized traditional Chinese medicine pharmacy, and in particular relates to a preparation method of Huashan ginseng granule. Background technique [0002] Asthma is a widespread and reversible airway narrowing disease caused by bronchial hyperresponsiveness caused by allergens or other factors. The clinical manifestations are recurrent chest tightness, wheezing, dyspnea, cough and other symptoms. Before the attack, there are often aura symptoms such as nasal congestion, sneezing, and itchy eyes. In severe cases, severe dyspnea and hypoxemia may occur within a short period of time, threatening life. There are about 2000-3000 deaths from asthma in the United States every year, and there is an increasing trend. In 2004, the Global Initiative for Asthma Prevention (GINA) estimated that there were about 300 million cases in the world, the prevalence of asthma in children and adults was about 3.3%-29% and 1.2%-25.5%...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/81A61K9/16A61P11/06
CPCA61K36/81A61K9/1623A61K9/1652A61K2236/333A61K2236/39A61K2236/55
Inventor 刘丹佟永领王金磊刘梦妮
Owner 津药达仁堂集团股份有限公司第六中药厂
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