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Method for judging development potential of embryos according to length of telomeres of granular cells

A technology of telomere length and granule cells, which is applied in the field of judging embryonic developmental potential to achieve the effect of reducing adverse environmental stimuli and being easy to operate.

Inactive Publication Date: 2015-03-25
LIUZHOU CITY HEALTHCARE HOSPITAL FOR WOMEN & CHILDREN
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

There is no relevant research report on the use of granulosa cell telomere length to judge the developmental potential of embryos

Method used

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  • Method for judging development potential of embryos according to length of telomeres of granular cells
  • Method for judging development potential of embryos according to length of telomeres of granular cells
  • Method for judging development potential of embryos according to length of telomeres of granular cells

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Embodiment 1

[0011] Example 1: A method for judging embryonic development potential by using the length of granulosa cell telomere. The length of granulosa cell telomere refers to the relative telomere length of granulosa cell, expressed by T / S value.

[0012] For women less than or equal to 35 years old, when the relative telomere length T / S value of the granulosa cell of the oocyte used for fertilization is 4.09~5.89, the embryo obtained is judged to be an embryo with high developmental potential and used for fertilization. When the granulosa cell relative telomere length T / S value of the cell is 1.95~3.95, the embryo obtained is judged to be an embryo with low developmental potential;

[0013] For women older than 35 years old, when the relative telomere length T / S value of the granulosa cell used for fertilization is 3.72~5.92, the embryo obtained is judged to be an embryo with high developmental potential, which is used for fertilization of oocytes. When the T / S value of granulosa cell rel...

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Abstract

The invention relates to a method for judging the development potential of embryos according to the length of telomeres of granular cells. According to the method, females are classified into an age group of 35 years old and under 35 years old and an age group of over 35 years old, and then the embryos of the females are judged as embryos with high development potential or embryos with low development potential according to the relative length (T / S value) of telomeres of granular oocytes for fertilization. The method provided by the invention can be used for judging the quality of embryos objectively, accurately, quantitatively and non-invasively, thus the incubator does not need to be taken out repeatedly to observe the embryos, and the stimulation to the embryos by adverse environment can be reduced. Because the method can be used for judging the quality of embryos quantitatively, and a specific range of values is available, the problem that the judgment standard on the quality of embryos is not uniform due to the influence of human subjective factors can be avoided. The method is easy to operate.

Description

Technical field [0001] The invention relates to a method for judging the developmental potential of embryos by using the telomere length of granular cells. Background technique [0002] The oocyte in the follicle is surrounded by a layer of rhombus or flat cells. As the follicle begins to develop and the egg cell grows, the surrounding rhomboid cells become cuboid and multiply from a single layer to a multi-layer, because of its cytoplasm It contains granules, so it is called granulosa cells. The telomere theory was put forward by Olovnikov. It is believed that cells cannot fully replicate their chromosomes due to the dysfunction of DNA polymerase during each division process. Therefore, the DNA sequence that is replicated may be lost and eventually cause cell senescence and death. Therefore, granule cells are generally related to the study of human aging. [0003] The success rate of in-vitro fertilization (in-vitro fertilization, IVF-ET) and intra-cytoplasmic sperm injection (I...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C12Q1/68C12Q1/04
CPCC12Q1/6881
Inventor 李楠王麟韦继红韦立红唐永梅牟联俊秦祖兴
Owner LIUZHOU CITY HEALTHCARE HOSPITAL FOR WOMEN & CHILDREN
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