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94 results about "Embryo quality" patented technology

Embryo quality is the ability of an embryo to perform successfully in terms of conferring a high pregnancy rate and/or resulting in a healthy person. Embryo profiling is the estimation of embryo quality by qualification and/or quantification of various parameters. Estimations of embryo quality guides the choice in embryo selection in in vitro fertilization.

Cow in-vitro fertilization embryo culture fluid and culture method thereof

The invention provides a culture fluid exclusively used in cow in-vitro fertilization embryos. The culture fluid contains 109.0mM-110mM of NaCl, 2.9mM-3.1mM of KCl, 26.0mM-26.5mM of NaHCO3, 0.5mM-1.0mM of MgCl2.6H2O, 1.0mM-1.3mM of KH2PO3, 0.4mM of sodium pyruvate, 1.5 mM of glucose, 5mM of galacturonic calcium, 10v / v% fetal bovine serum, 1mM of L- glutamine, 2v / v% essential amino-acid, 1v / v% nonessential amino acid and 1mM-10mM of glutathione. The cow in-vitro fertilization embryos are placed into the culture fluid to carry out in-vitro cultivation, and results are shown to be obviously superior to those of a control group which is not added with GSH (glutathione), and therefore, developmental rate of blastula and embryo quality are improved, cost for producing embryos in vitro is lowered, experimental basis is provided for applying a cow IVF (in vitro fertilization) technology to practice, and a genetic breeding process can be greatly accelerated.
Owner:INST OF ANIMAL SCI OF CHINESE ACAD OF AGRI SCI

Bovine in vitro fertilization embryo culture medium and culture method

The invention provides a culture fluid exclusively used in cow in-vitro fertilization embryos. The culture fluid contains 109.0mM-110mM of NaCl, 2.9mM-3.1mM of KCl, 26.0mM-26.5mM of NaHCO3, 0.5mM-1.0mM of MgCl2.6H2O, 1.0mM-1.3mM of KH2PO3, 0.4mM of sodium pyruvate, 1.5 mM of glucose, 5mM of galacturonic calcium, 10v / v% fetal bovine serum, 1mM of L- glutamine, 2v / v% essential amino-acid, 1v / v% nonessential amino acid and 1mM-10mM of glutathione. The cow in-vitro fertilization embryos are placed into the culture fluid to carry out in-vitro cultivation, and results are shown to be obviously superior to those of a control group which is not added with GSH (glutathione), and therefore, developmental rate of blastula and embryo quality are improved, cost for producing embryos in vitro is lowered, experimental basis is provided for applying a cow IVF (in vitro fertilization) technology to practice, and a genetic breeding process can be greatly accelerated.
Owner:INST OF ANIMAL SCI OF CHINESE ACAD OF AGRI SCI

Embryo quality assessment based on blastomere division and movement

The invention concerns a system and method for determining embryo quality comprising monitoring the embryo for a time period, said time period having a length sufficient to comprise at least one cell division period and at least a part of an inter-division period, and determining the length of the at least one cell division period; and / or ii) determining the extent and / or spatial distribution of cellular or organelle movement during the cell division period; and / or iii) determining duration of an inter-division period; and / or iv) determining the extent and / or spatial distribution of cellular or organelle movement during the inter-division period thereby obtaining an embryo quality measure. Thus, the selection of optimal embryos to be implanted after in vitro fertilization (IVF) is facilitated based on the timing, duration, spatial distribution, and extent of observed cell divisions and associated cellular and organelle movement.
Owner:UNISENSE FERTILITECH AS

Method for determining embryo quality

A method for determining embryo quality involving measuring soluble HLA-G levels present in the embryo culture medium at least 44-46 hours post-fertilization is provided. Culture media and in vitro fertilization programs employing same are also provided.
Owner:REPROCURE

Embryo quality evaluation assistance system, embryo quality evaluation assistance apparatus and embryo quality evaluation assistance method

ActiveUS20100195877A1Accurately cut outAccurate active siteCharacter and pattern recognitionSpecific use bioreactors/fermentersReactive siteEmbryo
An embryo quality evaluation assistance system including an image pickup unit for picking up an image of the embryo, and a computer that communicates data with the embryo observing apparatus to assist quality evaluation of the embryo. The computer includes a time-series image storing unit that stores a time-series image picked up by the embryo observing apparatus, an embryo image extracting unit that extracts an embryo image from the time-series image, and an active site extracting unit that compares an embryo image based on a first time-series image with an embryo image based on a second time-series image picked up before or after a predetermined time from a pickup time of the first time-series image, and extracts as an active site a set of pixels when the difference between pixel values of corresponding pixels of the first and second time-series images is larger than a predetermined threshold value.
Owner:DAI NIPPON PRINTING CO LTD +1

Culture liquid for promoting ectogenesis of frozen embryo after thawing

InactiveCN102250832AImprove later developmental abilityQuality improvementEmbryonic cellsVitrificationCulture fluid
The invention provides a culture liquid for promoting ectogenesis of embryo vitrified by an open pulled straw (OPS) method after thawing. Frozen 2-cell embryo after thawing is cultured in the culture liquid containing 10<-9> mol / L of melatonin (MT), so that the blastula development rate of the embryo is improved and the number of the cells in the embryo is increased, thereby improving the embryo quality, and providing a beneficial reference for further developing the study of OPS cryopreservation of livestock embryos.
Owner:定州市中农大朝来农产品开发有限责任公司

Systems and methods for generating a mask for automated assessment of embryo quality

Systems and methods for generating a mask for automated assessment of embryo quality are disclosed herein. The method for generating a mask for automated assessment of embryo quality can include receiving an image, including a plurality of pixels, of a human embryo from an imaging system. A pixel can be selected and features of the selected pixel can be determined by generating a plurality of random boxes of random sizes and at random locations about the selected pixel. The selected pixel can be identified as one of: inside of a mask area; and outside of the mask area based on the determined features.
Owner:ARES TRADING SA

Coating carrier and its use in method for sperm maturity detection and non-invasive mature sperm separation

The invention discloses a coated carrier and the application thereof in the method for detecting maturity of sperms and separating mature sperms noninvasively; the coated carrier is a carrier coated by hyaluronic acid, or hyalurate or hyaluronic acid derivatives; the detecting method is as follows: preparing specimens; loading the specimens to the coated carrier and covering with microscopic glass; reacting for 5-60 minutes at room temperature; observing by a microscope and counting; and calculating the combination ratio of hyaluronic acid of active sperms. The separating method is as follows: preparing specimens; loading the specimens to the coated carrier, reacting for 5-120 minutes at the temperature of 18-37 DEG C; and collecting the combined sperms. The coated carrier has the advantages of precise and reliable results, simple and fast operation, low cost and good safety performance, and can be used for estimating sperms quality, sperms maturity and analysis of the causes of sterility disease of mails, and is applicable to assisting reproduction or reproduction research center to safely collect mature and active sperms, so that the goal of improving embryo quality greatly is achieved.
Owner:SHENZHEN PEOPLES HOSPITAL

Non-invasive assays for embryo quality

Differentially expressed miRNA or small mRNA in the culture media of embryos were found to correlate to and affect embryo developmental fate. Accordingly the present invention provides a method for selecting a bovine embryo for implantation into a female bovine animal for further development based on the levels of specific miRNA or small mRNA. Also provided are methods of improving bovine embryo development fate by reducing in the culture medium the level of selected miRNAs.
Owner:WISCONSIN ALUMNI RES FOUND

Method for improving superovulating quantity and quality of sheep

The invention relates to the field of veterinary medicine for animal husbandry, and particularly provides a method for improving superovulating quantity and quality of sheep. The method comprises the following steps: injecting the sheep with estrous symptoms after superovulating treatment by using an injection with an effective component of melatonin through subcutaneous injection, wherein the injection dosage of the melatonin is 1-4 mL for each sheep (the melatonin concentration is 5 mg / mL). Animal experiments show that by the method, on the sixth day after insemination of a ewe, the total number of morulae / blastocysts flushed and the number of available embryos can be significantly increased, ova can be matured and the quality of inseminated embryos can be improved.
Owner:内蒙古金草原生态科技集团有限公司

Artificial reproduction pregnancy prediction method and device built by machine learning model

ActiveCN111933290AImprove the situation of overly conservative forecastsAvoid situations that affect the final resultMedical data miningKernel methodsPattern recognitionPregnancy
The invention relates to an artificial reproduction pregnancy prediction method and device built by a machine learning model. The method comprises: acquiring maternal blood hormone physiological detection data and ovarian function physiological detection data; establishing a hormone / physiological test-pregnancy SVM model in combination with a support vector machine algorithm; obtaining maternal embryo images; establishing an embryo image-embryo quality DNN model in combination with a deep neural network algorithm; obtaining a maternal clinical medical information prediction value according toa pregnancy test result report and the hormone / physiological test-pregnancy SVM model; obtaining an embryo quality evaluation prediction value according to the pregnancy test result report and the embryo image-embryo quality DNN model; and combining the two prediction values to obtain an artificial reproduction pregnancy prediction value. The method provided by the invention is relatively high inaccuracy, can avoid the situation that the final result is influenced due to the difference of different experiences, and can effectively improve the situation that a single model is easy to form over-conservative prediction when the data volume is small.
Owner:北京赫雅智能科技有限公司

Analysis of ova or embryos with digital holographic imaging

Method for analyzing a sample comprising at least one ovum or embryo, the method being based on digital holographic imaging, the method comprising the following steps: creating at least one object beam and at least one reference beam of light, where said at least one object beam and said at least one reference beam are mutually coherent; exposing said sample to said at least one object beam; superimposing said at least one object beam that has passed through said sample with said at least one reference beam and thereby creating an interference pattern; detecting said interference pattern, called hologram; reconstructing phase and / or amplitude information of object wavefront from said interference pattern; and constructing at least one ovum or embryo analysis image and determining at least one ovum or embryo quality showing parameter from said phase and / or amplitude information.
Owner:PHASE HOLOGRAPHIC IMAGING PHI

Method for analyzing embryo quality based on molecular immunoassay of mammalian blastulas

The invention discloses a method for analyzing embryo quality based on molecular immunoassay of mammalian blastulas. The expressions of key transcription factors OCT4 (octamer-binding transcription factor 4) and CDX2 (caudal-related homeodomain transcription 2) respectively expressing in inner cell masses and trophectoderm cells are used as the basis for analysis of the mammalian blastulas, and cellular level and molecular level analyses are carried out based on the immunostaining results of OCT4 and CDX2, so that the conventional blastula quality assessment method is covered, and the lineage differentiation with higher accuracy is proposed to conduct assessment; the blastulas with a proper ratio of the number of the inner cell masses to the number of the trophectoderm cells and complete first lineage differentiation are used as quality blastulas. Compared with the conventional blastula quality assessment method, the method disclosed by the invention not only can assess the blastula quality at a cellular level, but also can accurately assess the blastula quality and subsequent development potential at a molecular level, and the method is simple and high in accuracy and can provide technical support for embryonic implantation.
Owner:NORTHWEST A & F UNIV +1

Immature oocyte in vitro maturation promoting culture medium and application thereof

ActiveCN107460161AImprove the ability of in vitro culture and developmentIncrease available quantityCulture processGerm cellsMaturation oocyteCulture fluid
The invention relates to an immature oocyte in vitro maturation promoting culture medium and application thereof. The immature oocyte in vitro maturation promoting culture medium is screened out through research on effects of different additives on immature oocytes and prepared by adding 20-100 mu M of BAPTA-AM in normal oocyte in vitro maturation culture solution. The immature oocyte in vitro maturation promoting culture medium is safe and free to side and toxic effects, enables meiosis of the immature oocytes, particularly those in level 3 cumulus-oocyte complexes, improves the in vitro development of the oocytes, promotes maturation, improves the cleavage rate and the blastula development rate after the mature oocytes are parthenogenetically-activated and further improves embryo quality. Application of the immature oocyte in vitro maturation promoting culture medium provides favorable support for the technology of in vitro propagation of animal embryos.
Owner:CHINA AGRI UNIV

Method of determining endometrial receptivity

The present invention provides a method of predicting the probability of a successful pregnancy, either a naturally achieved pregnancy or a pregnancy resulting from an assisted reproductive technology, based on the level of L-selectin ligand expressed by uterine epithelial cells and / or the level of L-selectin expressed by an embryo in vitro. The invention further provides methods of inhibiting cell adhesion between a trophoblast and a uterine epithelial cell. Methods of inhibiting cell adhesion between a trophoblast and a uterine epithelial cell are useful to inhibit pregnancy. The invention further provides methods of assessing in vitro embryo quality. The invention further provides methods of predicting the probability of continued success of a pregnancy during the first 16 weeks of gestation.
Owner:RGT UNIV OF CALIFORNIA

General method of classifying plant embryos using a generalized Lorenz-Bayes classifier

A method of classifying plant embryos according to their quality based on a general form of Lorenz-Bayes classifier is disclosed. First, image or spectral data of plant embryos of known quality are acquired, and the data are divided into two classes according to the embryos' known quality. Second, metrics are calculated from the acquired image or spectral data in each class. Third, multi-dimensional histograms of multiple metrics are prepared for both classes. Fourth, the difference or some other measure of comparison between the two multi-dimensional histograms is obtained. Fifth, image or spectral data of a plant embryo of unknown quality are obtained and metrics are calculated therefrom. Sixth, the embryo of unknown quality is assigned to a class based on its calculated metrics and the result of the comparison as calculated in the fourth step above.
Owner:WEYERHAEUSER NR CO

Embryo quality evaluation assistance system, embryo quality evaluation assistance apparatus and embryo quality evaluation assistance method

An embryo quality evaluation assistance system including an image pickup unit for picking up an image of the embryo, and a computer that communicates data with the embryo observing apparatus to assist quality evaluation of the embryo. The computer includes a time-series image storing unit that stores a time-series image picked up by the embryo observing apparatus, an embryo image extracting unit that extracts an embryo image from the time-series image, and an active site extracting unit that compares an embryo image based on a first time-series image with an embryo image based on a second time-series image picked up before or after a predetermined time from a pickup time of the first time-series image, and extracts as an active site a set of pixels when the difference between pixel values of corresponding pixels of the first and second time-series images is larger than a predetermined threshold value.
Owner:DAI NIPPON PRINTING CO LTD +1

Method for evaluating human blastocyst by norepinephrine level in blastocyst culture solution

InactiveUS20140249363A1Accurately and noninvasively evaluatingHigh potential to implantMicrobiological testing/measurementDisease diagnosisOrganismTest object
The invention provides a new method for evaluating transfer embryos including blastocysts used for in vitro fertilization in fertility treatment, and a method for evaluating transfer embryos using a new biomarker necessary for evaluation. The method comprises the steps of (a) providing a test object, for example, a culture solution of a human blastocyst, containing norepinephrine (noradrenaline) released from a transfer embryo, such as a human blastocyst, obtained from a subject; (b) quantitatively analyzing norepinephrine in the test object by a combination of ultra high performance liquid chromatography and mass spectrometry or the like; (c) predicting the quality of the transfer embryo based on the amount of norepinephrine from analysis results obtained; and (d) transferring the embryo into a suitable female recipient for implantation, if the transfer embryo is predicted to be of good quality and / or to lead to the establishment of a viable pregnancy based on step (c).
Owner:YAMASHITA NAOKI

Culture solution and method for improving in-vitro maturation quality of porcine oocytes

The invention discloses a culture solution and method for improving the in-vitro maturation quality of porcine oocytes. The culture solution is prepared from the following components: an M199 culturesolution, 10 ng / mL of EGF, 10 [mu]M of asiatic acid, 0.6 mM of L-cysteine, 0.91 mM of sodium pyruvate, 10% follicular fluid, 10 IU / mL of LH, 10 IU / mL of FSH and 100 IU / mL of penicillin. According to the culture solution and method, the asiatic acid is added into the porcine oocyte in-vitro maturation culture solution for the first time, the maturation rate of the oocytes can be effectively increased, the quality of the oocytes can be effectively improved, the development rate of the oocytes can be effectively increased, the quality of the oocytes can be effectively improved, the developmentalrate of parthenogenetic embryos and in-vitro fertilized embryos can be increased, the embryo quality of the parthenogenetic embryos and the in-vitro fertilized embryos can be improved, and the problems of low efficiency and poor quality of in-vitro maturation and in-vitro culture at present are effectively solved.
Owner:JILIN UNIV

Method for remarkably improving callus inductivity of iris pseudacorus L.

The invention relates to the technical field of cell engineering tissue culture, and aims to provide a method for remarkably improving the callus inductivity of iris pseudacorus L. The method comprises the following steps: taking materials, configuring a callus induction culture medium, disinfecting an explant, inoculating the disinfected explant, and inducing a callus and an embryonic callus. Adopting a tender embryo of iris pseudacorus L. to serve as the explant, the method has the characteristics of low pollution rate and high material availability, and has the outstanding advantages of being high in callus induction efficiency, low in explant tender viruses, simple and convenient to operate, and high in obtained callus embryo quality.
Owner:ZHEJIANG UNIV

Embryo quality comprehensive evaluation device based on deep learning

The invention discloses an embryo quality comprehensive evaluation device based on deep learning. The device comprises a computer memory, a computer processor and a computer program which is stored inthe computer memory and can be executed on the computer processor, an embryo quality comprehensive evaluation model is stored in the computer memory, and when the computer processor executes the computer program, the following steps are realized: receiving an embryo image; identifying and segmenting a regional image of the cleavage ball through a cleavage ball target detection module; using the cell counting module to count cells in the regional image, and obtaining the development stage of the cleavage ball; using the embryo quality analysis module to score the development condition of the cleavage ball in the regional image; and in the prediction module, scoring the implantation possibility of the cleavage ball according to the regional image, and obtaining a prediction result of the implantation success rate of the cleavage ball by integrating the scores of the development conditions. The prediction result can assist a doctor in predicting the success rate of embryo implantation.
Owner:ZHEJIANG UNIV

Embryo noninvasive evaluation method and device

The invention relates to the technical field of embryo quality evaluation, and discloses an embryo noninvasive evaluation method and device, and the method comprises the following steps: obtaining a plurality of frames of development pictures of embryo continuous development, and extracting detail parameters of embryo development according to the development pictures; obtaining chromosome state parameters of chromosome examination before embryo implantation; performing correlation statistical operation on the detail parameters and the chromosome state parameters to obtain a correlation model of the node parameters and the chromosome state parameters; and evaluating embryonic development according to the association model. Embryo quality evaluation can be rapidly carried out, embryo in-vitro development time is shortened, and the influence of embryo evaluation on embryo development is avoided.
Owner:张孝东

Embryo quality assessment based on blastomere cleavage and morphology

The present invention relates to a method and system for selecting embryos for in vitro fertilization based on the observed timing and duration of cell cleavage and associated cell morphology, and more particularly to a method for determining embryo quality, the The method includes monitoring an embryo for a period of time, and determining one or more quality criteria for the embryo, wherein the one or more quality criteria are based on when the embryo develops from four blastomeres to eight blastomeres The degree of irregularity in the timing of cell division, and / or based on the determination of the time to cleavage into five blastomere embryos (t5) where t5 is between 48.7 hours and 55.6 hours, and / or based on two time intervals ratio, each of the two time intervals being determined as the duration of the time period between two morphological events in embryonic development from fertilization to eight blastomeres, and based on the one or more mass Standards determine embryo quality.
Owner:UNISENSE FERTILITECH AS

Embryo culture device and carrier thereof

ActiveCN106190840AUniform and stable culture environmentImprove developmentEmbryonic cellsTissue/virus culture apparatusNitrogenEmbryo
The invention relates to an embryo culture device, which comprises a culture tank, wherein the culture tank is provided with a cover; the culture tank and the cover are in threaded matching; air vents are formed in a covering screw thread of the culture tank; a carrier holding platform is arranged in the culture tank; the carrier holding platform is higher than the air vents; a carrier is arranged on the carrier holding platform; the bracket is of a hollowed porous structure which comprises a porous plate; and a convex ring is arranged on the porous plate. With the application of the device disclosed by the invention, the number of carbon dioxide incubators required by a test-tube baby laboratory can be remarkably reduced, so that the space of the laboratory can be greatly diminished and the consumption amounts of carbon dioxide and nitrogen can be greatly reduced; and the safety, stability and embryo quality of human embryo culture in vitro as well as the safety of the laboratory can be improved.
Owner:余裕炉

Embryo quality assessment based on blastomere division and movement

The invention concerns a system and method for determining embryo quality comprising monitoring the embryo for a time period, said time period having a length sufficient to comprise at least one cell division period and at least a part of an inter-division period, and determining the length of the at least one cell division period; and / or ii) determining the extent and / or spatial distribution of cellular or organelle movement during the cell division period; and / or iii) determining duration of an inter-division period; and / or iv) determining the extent and / or spatial distribution of cellular or organelle movement during the inter-division period thereby obtaining an embryo quality measure. Thus, the selection of optimal embryos to be implanted after in vitro fertilization (IVF) is facilitated based on the timing, duration, spatial distribution, and extent of observed cell divisions and associated cellular and organelle movement.
Owner:UNISENSE FERTILITECH AS

Embryo quality assessment based on blastomere cleavage and morphology

The present invention relates to a method and to a system for selecting embryos for in vitro fertilization based on the timing, and duration of observed cell cleavages and associated cell morphology.The invention especially relates to a method for determining embryo quality comprising monitoring the embryo for a time period, and determining one or more quality criteria for said embryo, wherein said one or more quality criteria is based on the extent of irregularity of the timing of cell divisions when the embryo develops from four to eight blastomeres, and / or wherein said one or more quality criteria is based on determining the time of cleavage to a five blastomere embryo (t5) and wherein t5 is between 48.7 hours and 55.6 hours, and / or wherein said one or more quality criteria is based on the ratio of two time intervals, each of said two time intervals determined as the duration of a time period between two morphological events in the embryo development from fertilization to eight blastomeres, and based on said one or more quality criteria determining the embryo quality.
Owner:UNISENSE FERTILITECH AS

Reagent and method for increasing sperm movement speed

The invention relates to a reagent and method for increasing the sperm movement speed. The reagent is prepared from progesterone, N6-Monobutyryladenosine-3',5'-cyclic monophosphate and Calcium Ionophore A23187, wherein the concentration ratio of progesterone to N6-Monobutyryladenosine-3',5'-cyclic monophosphate to Calcium Ionophore A23187 is (10-100 microgram / ml):(1-10mM):(1-10mM). The method includes the steps that a sperm culture solution is laid flat on a liquefied semen sample, and after 0.8-1.2 h of upward swimming, liquid at the uppermost end is extracted to obtain capacitated sperms; then, a sterile straw is filled with a sperm culture solution, the reagent is added into the top, the sterile straw is inserted into the upper portion of the capacitated sperms, and after 0.8-1.2 h of upward swimming, liquid at the upper end is collected. By means of the method, the sperm movement speed can be greatly increased, and a theoretical basis is provided for increasing the in-vitro fertilization rate or improving the embryo quality.
Owner:SHANGHAI FIRST MATERNITY & INFANT HOSPITAL

Screening method of different metabolites for evaluating goat transgenic cloned embryo quality based on gas chromatography-mass spectrum combined technique and morphology

The invention discloses a screening method of different metabolites for evaluating goat transgenic cloned embryo quality based on a gas chromatography-mass spectrum combined technique and morphology. The screening method comprises the following steps that 1, reconstructed embryos are cultured for 48 hours, the cleavage rate is checked, cleaved embryos are divided into a high-quality cleaved embryo group and a low-quality cleaved embryo group according to the morphology, the embryo groups are randomly put into blastocyst culture droplets for continuous culture; 2, the blastocyst rate statistics is performed at 7.5 d, and blastocysts and embryo metabolites of the high-quality cleaved embryo group and the low-quality cleaved embryo group are respectively collected; 3, the collected embryo metabolite samples are processed, and gas chromatography-mass spectrum detection is performed; 4, detection results are subjected to statistic analysis. The screening method is integrated with morphological evaluation of the embryos to find metabolism markers closely correlated with the goat transgenic cloned embryo quality, provides a reference for research on prediction of embryonic developmental potential and facilitates screening of high-quality transplanted embryos and improvement of transgenic cloning efficiency.
Owner:NANJING AGRICULTURAL UNIVERSITY

Composition for improving ovarian function and improving ovum and embryo quality and application thereof

The invention discloses a composition for improving ovarian function and improving ovum and embryo quality and application thereof. The invention provides the composition containing nicotinamide mononucleotide, melatonin and coenzyme Q10, the ovulation rate of old animals can be remarkably improved, the maturation rate and fertilization rate of ova and the development rate of early embryos are increased, and the composition has great significance in prevention and treatment of female infertility and in-vitro production of animal embryos. The three active ingredients in the composition are endogenous substances of a biological organism, and side effects cannot be generated from published literatures, so that the safety of the composition serving as a medicine, a health care product or a biological preparation has very high safety.
Owner:南京欧赛康生物科技有限公司

Free nucleic acids and mirna as non-invasive method for determining embryo quality

The present invention relates generally to the fields of reproductive medicine. More specifically, the present invention relates to in vitro non-invasive methods for determining the quality of an embryo by determining the level of the cell free nucleic acids or miR-29a or let7-b in the nucleic acid extract from a follicular fluid sample.
Owner:INST NAT DE LA SANTE & DE LA RECHERCHE MEDICALE (INSERM) +2
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