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Embryo noninvasive evaluation method and device

A technology of embryo and embryo development, applied in the direction of instruments, biological neural network models, bioinformatics, etc., can solve the problems of embryo development impact, screening and evaluation time-consuming, etc., to reduce culture time, reduce iatrogenic waste, and avoid impact Effect

Active Publication Date: 2019-10-22
张孝东
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] The purpose of the present invention is to overcome the above-mentioned technical deficiencies, provide a non-invasive evaluation method and device for embryos, and solve the technical problems in the prior art that the screening evaluation takes a long time and affects the development of embryos

Method used

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  • Embryo noninvasive evaluation method and device

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Embodiment 1

[0022] Such as figure 1 As shown, Embodiment 1 of the present invention provides a non-invasive evaluation method for embryos, comprising the following steps:

[0023] S1. Acquiring multiple frames of developmental pictures of continuous embryo development, and extracting detailed parameters of embryonic development according to the developmental pictures;

[0024] S2. Obtaining the chromosome state parameters of the pre-implantation chromosome examination;

[0025] S3. Perform correlation statistical calculations on the detailed parameters and the chromosome state parameters to obtain a correlation model between the node parameters and the chromosome state parameters;

[0026] S4. Evaluate embryonic development according to the association model.

[0027] In the embodiment of the present invention, the detailed parameters of embryo development are obtained according to the continuous development pictures of embryos obtained by the time-lapse microscope, and the detailed cha...

Embodiment 2

[0085] Embodiment 2 of the present invention provides an embryo non-invasive evaluation device, including a processor and a memory, and a computer program is stored on the memory. When the computer program is executed by the processor, the embryo non-invasive evaluation provided by any of the above embodiments can be realized. assessment method.

[0086] The embryo non-invasive evaluation device provided by the present invention is used to implement the embryo non-invasive evaluation method. Therefore, the embryo non-invasive evaluation device also has the technical effects of the above-mentioned embryo non-invasive evaluation method, and will not be repeated here.

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Abstract

The invention relates to the technical field of embryo quality evaluation, and discloses an embryo noninvasive evaluation method and device, and the method comprises the following steps: obtaining a plurality of frames of development pictures of embryo continuous development, and extracting detail parameters of embryo development according to the development pictures; obtaining chromosome state parameters of chromosome examination before embryo implantation; performing correlation statistical operation on the detail parameters and the chromosome state parameters to obtain a correlation model of the node parameters and the chromosome state parameters; and evaluating embryonic development according to the association model. Embryo quality evaluation can be rapidly carried out, embryo in-vitro development time is shortened, and the influence of embryo evaluation on embryo development is avoided.

Description

technical field [0001] The invention relates to the technical field of embryo quality evaluation, in particular to a method and device for non-invasive evaluation of embryos. Background technique [0002] The existing embryo non-invasive scoring system basically adopts the Istanbul expert consensus, that is, the number of pronuclei, speed, blastomere uniformity, embryonic debris content, single-nucleus or multi-nucleus status of a single blastomere, and other cytoplasmic morphology from embryos in vitro Characteristics determine the developmental potential of an embryo. With the introduction of the delayed camera technology incubator TLS, the embryo evaluation has been brought into the category of "developmental dynamics", that is, embryos with high developmental potential follow a certain development speed, and go through a division cycle in 18-20 hours. Therefore, most of the current commercial TLS culture evaluation software is based on the screening of embryos based on ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G06K9/62G06K9/46G06N3/04G16B35/00
CPCG16B35/00G06V10/40G06N3/045G06F18/2193G06F18/2415Y02A90/10
Inventor 张孝东
Owner 张孝东
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