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Composition for improving ovarian function and improving ovum and embryo quality and application thereof

A technology for embryo quality and ovarian function, applied in the field of biomedicine, can solve the problems of low in vitro production capacity of animal embryos, decreased oocyte quality, etc., and achieve the effects of high safety, improved ovulation rate, and improved egg quality.

Pending Publication Date: 2020-11-20
南京欧赛康生物科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention is to provide a nicotinamide mononuclear cell for the reduction of oocyte quality, female infertility, and low in vitro production capacity of animal embryos caused by aging, disease, and environmental pollution. Application of nucleotide and a new pharmaceutical composition containing nicotinamide mononucleotide, melatonin and coenzyme Q10

Method used

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  • Composition for improving ovarian function and improving ovum and embryo quality and application thereof
  • Composition for improving ovarian function and improving ovum and embryo quality and application thereof
  • Composition for improving ovarian function and improving ovum and embryo quality and application thereof

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Experimental program
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Effect test

Embodiment

[0031] 1. The configuration of the in vitro maturation solution of aged mouse oocytes and the addition of the composition

[0032] The in vitro maturation solution is M16 (sigma, product number M7292), the composition is composed of nicotinamide mononucleotide, melatonin and coenzyme Q10, and the concentration of nicotinamide mononucleotide in the in vitro maturation culture solution is 200 μM, and the The concentration of melanin was 10 μM, and the concentration of coenzyme Q10 was 50 μM.

[0033] 2. Obtainment of aged mouse oocytes, in vitro culture and statistics of maturation rate

[0034] Old mice were injected with 10IU / mL pregnant horse serum gonadotropin (Ningbo Third Hormone Products Co., Ltd., China) 48 hours later, and the mice were sacrificed by neck dislocation. Take out the ovaries and chop them up and take out the GV stage oocytes with a mouth pipette. After taking out the oocytes, put them into the in vitro maturation culture medium or the in vitro maturation ...

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Abstract

The invention discloses a composition for improving ovarian function and improving ovum and embryo quality and application thereof. The invention provides the composition containing nicotinamide mononucleotide, melatonin and coenzyme Q10, the ovulation rate of old animals can be remarkably improved, the maturation rate and fertilization rate of ova and the development rate of early embryos are increased, and the composition has great significance in prevention and treatment of female infertility and in-vitro production of animal embryos. The three active ingredients in the composition are endogenous substances of a biological organism, and side effects cannot be generated from published literatures, so that the safety of the composition serving as a medicine, a health care product or a biological preparation has very high safety.

Description

Technical field [0001] The invention belongs to the field of biomedicine and relates to a composition for improving ovarian function and egg and embryo quality and its application. Background technique [0002] The normal development of oocytes is a prerequisite to ensure egg maturity, fertilization and embryo development, and is the material basis for the beginning of life. The quality of oocytes not only affects human reproductive health, but is also of great significance to the in vitro production of animal embryos. [0003] During the in vitro culture process, due to the decline in the quality of the oocytes themselves and the influence of aging and other factors, the maturation of the oocytes is greatly affected. Not only is the oocyte maturation rate low, but the decline in egg quality also leads to fertilization. Ability and subsequent embryonic developmental potential are greatly affected. [0004] Elderly women refer to women over the age of 35. The main reasons f...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/706A61K31/4045A61K31/122A61P15/08C12N5/075A23L33/13A23L33/10A23K20/153A23K20/00A23K20/132
CPCA23V2002/00A61K31/122A61K31/4045A61K31/706A23K20/00A23K20/132A23K20/153A23L33/10A23L33/13A61P15/08C12N5/0609C12N2500/30C12N2500/32C12N2500/34C12N2500/38C12N2500/40C12N2501/11C12N2501/30C12N2501/31C12N2501/999A61K2300/00A23V2200/30
Inventor 熊波苗义龙高倩
Owner 南京欧赛康生物科技有限公司
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