Blood flower milkweed milk extract rich in cardiac glycosides as well as preparation method and application of extract

Abstract

The invention belongs to the chemical field of natural medicine and discloses a blood flower milkweed milk extract rich in cardiac glycosides as well as a preparation method and an application of the extract. The preparation method of the extract comprises the following steps: (1) diluting the milk of the blood flower milkweed by use of water to obtain a diluent; adding an organic solvent to the diluent for extracting, and collecting the organic layer obtained after extraction; next, adding the organic solvent to the left water layer for extracting, collecting the organic layer again, and circularly extracting for 2-4 times, and then abandoning the water layer, and blending the organic the organic layers to obtain the cardiac glycoside extract of the blood flower milkweed milk; (2) performing reduced pressure concentration on the blood flower milkweed milk until a constant weight, thereby obtaining the blood flower milkweed milk extract rich in cardiac glycosides. The blood flower milkweed milk extract rich in cardiac glycosides has excellent anti-tumor activity and low toxicity to normal cells; the extract contains a plurality of types of cardiac glycosides rich in content. The preparation method of the blood flower milkweed milk extract rich in cardiac glycosides is simple, low in cost, high in extraction rate, and high in anti-tumor selectivity.

Description

technical field

[0001] The invention belongs to the field of natural medicinal chemistry, and particularly relates to a milkweed milk extract rich in cardiac glycosides, a preparation method thereof and an application in antitumor drugs. Background technique

[0002] According to a survey report published by the World Health Organization on February 1, 2013, the number of people who died of cancer in the world in 2008 reached 7.6 million, and there were about 13 million new cancer patients every year, of which nearly 60% were lung cancer, gastric cancer, breast cancer, Prostate cancer, colorectal cancer, oral cancer, liver cancer, cervical cancer and esophageal cancer are the second leading causes of death after cardiovascular disease. At present, cancer treatment includes surgery, radiotherapy and chemotherapy, intervention and other means, but the mortality rate is still high. Experts and scholars from all over the world are actively researching to find methods and drugs ...

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