Unlock instant, AI-driven research and patent intelligence for your innovation.
2-oxo-1,2-dihydrobenzo[cd]indole-6-sulfonamide compounds and their compositions and applications
What is Al technical title?
Al technical title is built by PatSnap Al team. It summarizes the technical point description of the patent document.
A technology of dihydrobenzene and sulfonamide, applied in the field of chemical medicine
Active Publication Date: 2018-03-20
GUANGZHOU INST OF BIOMEDICINE & HEALTH CHINESE ACAD OF SCI
View PDF3 Cites 0 Cited by
Summary
Abstract
Description
Claims
Application Information
AI Technical Summary
This helps you quickly interpret patents by identifying the three key elements:
Problems solved by technology
Method used
Benefits of technology
Problems solved by technology
However, further studies have shown that digoxin has strong side effects and that ursolic acid also acts on glucocorticoid receptors
Method used
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more
Image
Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
Click on the blue label to locate the original text in one second.
Reading with bidirectional positioning of images and text.
[0074] Add 1,8-naphthalic anhydride (1-1) (11.9 g, 0.06 mol), hydroxylaminehydrochloride (4.18 g, 0.06 mol) and pyridine (70 mL) into a round bottom flask, and heat to reflux for 1 hour. After cooling to 80°C, 4-toluenesulfonyl chloride (22.88 g, 0.12 mol) was quickly added, and the temperature was raised to reflux for 1.5 hours. After cooling to room temperature, the mixture was poured into 200 g of ice water, and a yellow precipitate precipitated out after stirring. Stand still, filter with suction, wash with water three times, stir and wash with saturated sodiumbicarbonatesol...
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
PUM
Login to View More
Abstract
Provided in the present invention are a compound having a structural feature of the general formula I as a novel retinoic acid orphan nuclear receptor γ subtype (RORγ) inhibitor, and the uses of the compound and a pharmaceutically acceptable salt, isomer, racemate, prodrug co-crystallizing complex, hydrate and solvate in the drug for treating or preventing a disease associated with RORγ regulation and control.
Description
technical field [0001] The invention belongs to the technical field of chemistry and medicine, and in particular relates to a class of 2-oxo-1,2-dihydrobenzo[cd]indole-6-sulfonamide derivatives and pharmaceutically acceptable salts or stereoisomers thereof. Constructs and prodrug molecules and preparation methods thereof, as well as the application of such compounds in the preparation of drugs for the treatment of immune-related diseases regulated by RORγ. Background technique [0002] Retinoic acid-related orphan nuclear receptor (ROR) is a member of the nuclear receptor family, which can regulate a variety of physiological and biochemical processes. The ROR family includes three types RORα, RORβ, and RORγ. Three different RORs can be expressed in different tissues and regulate different physiological processes. RORα is mainly distributed in liver, skeletal muscle, skin, lung, adipose tissue, kidney, thymus, and brain. RORβ has a small range of action and mainly acts on t...
Claims
the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More
Application Information
Patent Timeline
Application Date:The date an application was filed.
Publication Date:The date a patent or application was officially published.
First Publication Date:The earliest publication date of a patent with the same application number.
Issue Date:Publication date of the patent grant document.
PCT Entry Date:The Entry date of PCT National Phase.
Estimated Expiry Date:The statutory expiry date of a patent right according to the Patent Law, and it is the longest term of protection that the patent right can achieve without the termination of the patent right due to other reasons(Term extension factor has been taken into account ).
Invalid Date:Actual expiry date is based on effective date or publication date of legal transaction data of invalid patent.
![2-oxo-1,2-dihydrobenzo[cd]indole-6-sulfonamide compounds and their compositions and applications](https://images-eureka.patsnap.com/patent_img/7b7bb9ad-25d1-4f6a-b52e-d465e4924970/DEST_PATH_IMAGE001.png)
![2-oxo-1,2-dihydrobenzo[cd]indole-6-sulfonamide compounds and their compositions and applications](https://images-eureka.patsnap.com/patent_img/7b7bb9ad-25d1-4f6a-b52e-d465e4924970/DEST_PATH_IMAGE002.png)
![2-oxo-1,2-dihydrobenzo[cd]indole-6-sulfonamide compounds and their compositions and applications](https://images-eureka.patsnap.com/patent_img/7b7bb9ad-25d1-4f6a-b52e-d465e4924970/DEST_PATH_IMAGE003.png)
Login to View More 
Login to View More