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An orthopedic or dental filling material, a dental implant and a degradable artificial bone

A technology of filling materials and dental implants, applied in dental prosthesis, dentistry, prosthesis, etc., can solve the problems of inability to promote rapid restoration of dental tissue, early osteogenesis, poor osseointegration, and slow osteogenesis process

Active Publication Date: 2016-11-23
CHANGZHOU KANGWEI BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] In order to solve the defects that the existing dental filling materials cannot promote the rapid restoration of tooth tissue, the existing dental implants have poor early osteogenesis and osseointegration, the bone filling materials have insufficient induction ability to new bone, and the osteogenesis process is slow , the invention provides an orthopedic or dental filling material, a dental implant and a degradable artificial bone

Method used

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  • An orthopedic or dental filling material, a dental implant and a degradable artificial bone

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0076] Orthopedic or dental filling material provided by the present invention, the preparation method of the support of described filling material comprises the following steps:

[0077] (1) preparing a mass concentration of 1% hydrophilic macromolecule aqueous solution, preparing a mass concentration of 3% glutaraldehyde aqueous solution, preparing a concentration of polypeptide aqueous solution of 10 μg / ml,

[0078] The above-mentioned hydrophilic macromolecule is collagen; the above-mentioned polypeptide is osteopontin (OPN) contained in bones; the hydrophilic macromolecule material is added with a mass percentage of 0.0001% of a small molecular compound that promotes the proliferation of osteoblasts .

[0079] (2) Preparation of hydrogel substrate: the three aqueous solutions prepared in step (1) were mixed according to the volume ratio of 1:1:1, stirred at room temperature for 0.5 minutes, and then the mixture was placed on the carrier, The hydrogel substrate was prepar...

Embodiment 2

[0084] Orthopedic or dental filling material provided by the present invention, the preparation method of the support of described filling material comprises the following steps:

[0085] (1) preparing a mass concentration of 5% hydrophilic macromolecule aqueous solution, preparing a mass concentration of 8% glutaraldehyde aqueous solution, preparing a concentration of polypeptide aqueous solution of 300 μg / ml,

[0086] The above-mentioned hydrophilic macromolecule is gelatin; the above-mentioned polypeptide is phosphophoryn or its fragments contained in teeth; the above-mentioned hydrophilic macromolecule material is added with a mass percentage of 5% of a small molecular compound that promotes the proliferation of osteoblasts.

[0087] (2) Preparation of hydrogel substrate: the three aqueous solutions prepared in step (1) were mixed according to the volume ratio of 1:1:1, stirred at room temperature for 10 minutes, and then the mixture was placed on the carrier, The hydrogel...

Embodiment 3

[0092] Orthopedic or dental filling material provided by the present invention, the preparation method of the support of described filling material comprises the following steps:

[0093] (1) preparing a mass concentration of 3% hydrophilic macromolecule aqueous solution, preparing a mass concentration of 6% glutaraldehyde aqueous solution, preparing a concentration of 150 μg / ml polypeptide aqueous solution,

[0094] The above-mentioned hydrophilic macromolecule is a composition of collagen and gelatin, and the weight ratio of collagen and gelatin is 1:3; the above-mentioned polypeptide is a polypeptide rich in aspartic acid, wherein the sum of said aspartic acid accounts for The weight percentage is 10%; the hydrophilic macromolecular material is added with a mass percentage of 2.5% of a small molecular compound that promotes the proliferation of osteoblasts.

[0095] (2) Preparation of hydrogel substrate: the three aqueous solutions prepared in step (1) were mixed according ...

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Abstract

The invention relates to the technical field of a medical biomaterial, and particularly relates to an orthopedics or dental filling material. The invention provides an orthopedics or dental filling material, a dental implant and a degradable artificial bone, which aim at solving the defects that the existing dental filling material cannot promote fast restoration of tooth tissues, a bone filling material is insufficient for the inducibility of new bones and the bone forming process is slow. The filling material comprises a stent, and an active factor is attached to the stent; the stent comprises a stent body which is made of hydrogel materials, and hydroxyapatite is deposited on the stent body; and the concentration of the stent is 0.000001-100mg / cm<3>. The orthopedics or dental filling material has stronger capability of inducting the formation of new bones, as well as good bone defect repair capability, and strong capability of promoting the formation of tooth tissues.

Description

technical field [0001] The invention relates to the technical field of medical biomaterials, in particular to an orthopedic or dental filling material, a dental implant and a degradable artificial bone. Background technique [0002] According to relevant statistics, the incidence rate of dental caries in the population of our country is 37%, with an average of 2.47 dental caries per person. There is a great demand for filling materials for repairing dental caries, and the estimated annual demand is about 1 ton. However, none of the currently used dental filling materials can promote rapid restoration of tooth tissue. Moreover, with people's pursuit of high-quality life, when teeth fall off, people usually plant dentures again. Based on the above-mentioned needs of people, relevant manufacturers provide multiple dental implants. A dental implant is composed of a base, a neck, and a body. In the structure of the dental implant, the base refers to the part where the dental i...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K38/22A61L27/54A61L27/12A61L27/52A61L27/56A61L27/22A61K6/04A61K6/033A61K6/02A61K6/838
Inventor 戴立军
Owner CHANGZHOU KANGWEI BIOTECH
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