Preparation method of special chromatography separation medium for separating fullerene and derivatives of fullerene

Abstract

The invention relates to a preparation method of a special chromatography separation medium for separating fullerene and derivatives of fullerene. The method is characterized by comprising the following specific steps: (1) adding 5-50g of a porous amino silicone ball to 50-500mL of methylbenzene, stirring, moistening and dispersing evenly; (2) adding 4-40g of pyrene caproic acid to methylbenzene suspending the porous amino silicone ball, stirring and mixing evenly; (3) adding a condensation agent, reacting at 80 DEG C for 24 hours, and filtering; (4) adding a bonded silica ball to 50-500mL of methylbenzene again, adding 10-100g of penta benzyl bromide, reacting at 80 DEG C for 24 hours, and filtering; and (5) washing with 50-500mL of methylbenzene for three times, and drying at 80 DEG C to obtain the chromatography separation medium. According to the chromatography separation medium bonded by two groups, the bonding density and the separation selectivity are superior to those of a bonded single group; especially the preparation load capacity is relatively large; and the preparation efficiency can be significantly improved.

Description

【Technical Field】 [0001] The invention relates to the technical field of chromatographic separation media, in particular to a preparation method of a chromatographic separation media special for the separation of fullerenes and their derivatives. 【Background technique】 [0002] Fullerenes and their different derivatives have been developed one after another. Under normal circumstances, the activity and effect of fullerene derivatives are better than that of a single fullerene. This is also the main reason why new fullerene derivatives, including metal fullerenes, have become research hotspots. However, due to the similarity of their structures, the separation, analysis and purification of these compounds have also brought great problems. [0003] Due to the increasing number of fullerene derivatives, the separation difficulties caused are increasing. The traditional single-bonded fillers can no longer meet the current separation requirements, so we are now bonding pyrene and penta...

AI Technical Summary

Problems solved by technology

However, due to the similarity of their structures, it also brings great problems to the separation analysis and separation and purification of these compounds.

[0003] As there are more and more derivatives of fullerene, the difficulty of separation is also increasing. The traditional single-bonded packing can no longer meet the current separation requirements, so we now bond pyrene and pentabromobenzene in two parts. on the same silicon sphere

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