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A kind of biofunctionalized carbon/carbon composite material and preparation method thereof

A carbon composite material and biological functionalization technology, applied in the field of biomedicine, can solve the problems of slow biodegradation rate, insufficient interface bonding strength, accelerated osseointegration speed and anti-infection of artificial bone materials, etc., achieve good interface bonding strength, improve The effect of osseointegration

Active Publication Date: 2017-03-08
CHINA UNIV OF PETROLEUM (EAST CHINA)
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the coating or thin film materials prepared by the above scheme can prevent the free carbon particles from falling off the surface of carbon / carbon composite materials and improve the biological activity, they all have clinical application problems such as insufficient interfacial bonding strength and slow biodegradation rate, so they have not been used. Can truly endow artificial bone materials with biological functions of accelerating osseointegration and anti-infection

Method used

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  • A kind of biofunctionalized carbon/carbon composite material and preparation method thereof
  • A kind of biofunctionalized carbon/carbon composite material and preparation method thereof
  • A kind of biofunctionalized carbon/carbon composite material and preparation method thereof

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Effect test

Embodiment 1

[0056] A biofunctionalized carbon / carbon composite material, which uses the carbon / carbon composite material as a matrix, and grafts antibacterial functional groups and vascular endothelial growth factors on the surface of the matrix.

[0057] The method for preparing biofunctionalized carbon / carbon composite materials, the preparation method is as follows:

[0058] First, the carbon / carbon composite matrix is ​​pretreated, and the monolayer of antibacterial functional groups are modified on the surface of the pretreated carbon / carbon composite matrix, and then the vascular endothelial growth factor is immobilized on the carbon by graft copolymerization technology. / carbon composite matrix surface, that is, to obtain biofunctionalized carbon / carbon composite composite materials;

[0059] The antibacterial functional group is selected from carboxymethyl chitosan or hyaluronic acid.

Embodiment 2

[0061] A method of preparing a biofunctionalized carbon / carbon composite material,

[0062] The carbon / carbon composite material matrix pretreatment includes two steps of carbon / carbon composite material graphitization treatment and plasma glow surface treatment; the specific steps are as follows:

[0063] 1) Graphitization treatment of carbon / carbon composite materials

[0064] a. Process the carbon / carbon composite matrix into a specification of After surface polishing, the samples were ultrasonically cleaned in dichloromethane, acetone, absolute ethanol and deionized water for 10 minutes respectively, and then annealed at 2400 ° C for 2 h in an Ar protective atmosphere to obtain graphite Carbon / carbon composite matrix after chemical treatment;

[0065] 2) Plasma glow surface treatment

[0066] The surface of the graphitized carbon / carbon composite material sample obtained in step 1) is "washed" by using a radio frequency plasma gas phase reactor to obtain a pretreated c...

Embodiment 3

[0075] A method of preparing a biofunctionalized carbon / carbon composite material,

[0076] The carbon / carbon composite material matrix pretreatment includes two steps of carbon / carbon composite material graphitization treatment and plasma glow surface treatment; the specific steps are as follows:

[0077] 1) Graphitization treatment of carbon / carbon composite materials

[0078] a. Process the carbon / carbon composite matrix into a specification of After surface polishing, the samples were ultrasonically cleaned in dichloromethane, acetone, absolute ethanol and deionized water for 10 minutes respectively, and then annealed at 2400 ° C for 2 h in an Ar protective atmosphere to obtain graphite Carbon / carbon composite matrix after chemical treatment;

[0079] 2) Plasma glow surface treatment

[0080] The surface of the graphitized carbon / carbon composite material sample obtained in step 1) is "washed" by using a radio frequency plasma gas phase reactor to obtain a pretreated c...

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Abstract

The invention belongs to the field of biomedicine, and in particular relates to a bio-functionalized modification method for the surface of a carbon / carbon composite material. By virtue of the chemical modification method, the carbon / carbon composite material has a surface modified layer satisfying the requirements of composite clinical application, and vascular endothelial growth factors are immobilized on the surface of the carbon / carbon composite material by virtue of a graft copolymerization technology. The immobilization of polysaccharide molecules and the vascular endothelial growth factors on the surface of the carbon / carbon composite material is achieved through the methods of free radical substitution and coupling grafting; by constructing a surface bio-functionalized modified layer which has chemical bonding characteristics with the matrix of the carbon / carbon composite material, the osseointegration performance of a carbon / carbon composite material artificial bone material is improved and the good bone tissue compatibility of the artificial bone material is guaranteed; through the bio-functionalized modification on the surface of the carbon / carbon composite material by virtue of antibacterial molecular groups and the vascular endothelial growth factors capable of regulating the differentiation and proliferation of bone cells, the problem that the existing carbon / carbon composite material-based artificial bone which is poor in osseointegration effect for a long time is solved; and the carbon / carbon composite material can meet clinical application.

Description

[0001] Technical field: [0002] The invention belongs to the field of biomedicine, and in particular relates to a method for biofunctional modification of the surface of a carbon / carbon composite material. A chemical modification method is used to make the carbon / carbon composite material obtain the surface modification layer required for composite clinical use, and the vascular endothelial growth factor is fixed on the surface of the carbon / carbon composite material through graft copolymerization technology. [0003] Background technique: [0004] Carbon / carbon composites inherit the inherent bioinert characteristics of carbon materials and can meet the basic requirements for the biocompatibility of artificial bone materials. Compared with traditional medical metal and bioceramic materials, its elastic modulus is closer to that of human bone tissue, and the body tissue has better mechanical adaptability to it, so it is more in line with the biological fixation principle of mo...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L27/34A61L27/54A61L27/08C04B41/80
Inventor 曹宁王勇张园杨柏吕倩
Owner CHINA UNIV OF PETROLEUM (EAST CHINA)