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Capsule skin of chewable soft capsules with immunity enhancing function and soft capsules prepared from capsule skin

A technology for enhancing immunity and capsule skin, which can be used in medical preparations with non-active ingredients, capsule delivery, food forming, etc., and can solve the problems of insufficient application, affecting product shelf life, and unsatisfactory chewability. Achieve synergistic moisturizing, dissolving and diffusion, balancing odor and content taste, and novel formula composition.

Active Publication Date: 2015-05-20
安徽钙尔奇生物医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Existing soft capsules and their preparation have the following deficiencies: (1) the chewability is not ideal, and the stability is relatively poor; at present, it is mainly increased by adding plasticizers, polymer modifiers and water to the formula. Its chewing performance, for example, US Patent US6280767 discloses a chewable soft capsule, which keeps the capsule soft by increasing the amount of plasticizer, wherein gelatin in the rubber prescription: plasticizer=100:100~600 ; U.S. Patent US20050136104 discloses a chewable soft capsule, which keeps the capsule soft by maintaining a high moisture content, wherein the water content in the rubber is as high as 27%; patent WO2011014942 discloses a chewable soft capsule , the soft capsule maintains a certain softness and water-locking property by adding 10-20% starch in the rubber, so that the rubber is easy to chew; although the above-mentioned technology can obtain a certain improvement in its chewing performance and rubber softness, but At the same time, it will also cause the soft capsules to be deformed or bonded due to mutual extrusion, thereby affecting the shelf life of the product; (2) The taste is not good; due to the smell of the rubber itself, and the content accounts for 60-90% of the weight of the whole capsule , the bad smell of some raw materials in the content will greatly affect the taste when people take it
In the prior art, β-glucan is mainly used as a moisturizing agent in the preparation process of soft capsules, and its effect of improving immunity has not been fully applied

Method used

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  • Capsule skin of chewable soft capsules with immunity enhancing function and soft capsules prepared from capsule skin
  • Capsule skin of chewable soft capsules with immunity enhancing function and soft capsules prepared from capsule skin

Examples

Experimental program
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Effect test

Embodiment 1

[0026] Example 1 A capsule skin of a chewable soft capsule with an immune-enhancing effect is prepared from the following mass ratio components: gelatin with a freezing strength of 150: glycerin: purified water: sweetener (crystallized fructose): natural flavoring agent ( Apple extract): β-glucan (molecular weight 50kD)=30:15:30:10:1:1:

[0027] (1) Dissolve the natural flavoring agent in purified water with an amount of 15% purified water, mix well, heat to 30~32°C, add β-glucan, continue to stir for 10 minutes, and then place it under ultrasonic wave with a frequency of 60KHz for ultrasonic treatment 15mim, to get β-glucan solution;

[0028] (2) Set the jacket temperature of the chemical tank to 65°C to heat the chemical tank, add glycerin, the remaining purified water, and sweetener to the chemical tank, turn on the electric stirring for 25 minutes until the materials are evenly dissolved, and then add the β-glucan solution , continue stirring for 10 minutes;

[0029] (3)...

Embodiment 2

[0032] Example 2 The capsule skin of a chewable soft capsule with immune-enhancing effect is prepared from the following mass ratio components: gelatin with a freezing strength of 200: glycerin: purified water: sweetener (steviol glycoside): natural flavoring agent ( Blueberry powder, black currant powder): β-glucan (molecular weight 1000kD)=25:20:25:11:1.8:0.5:

[0033] (1) Dissolve the natural flavoring agent in purified water with 20% purified water, mix well, heat to 30~32°C, add β-glucan, continue to stir for 5 minutes, and then put it under ultrasonic treatment with a frequency of 55KHz 22mim, to get β-glucan solution;

[0034] (2) Set the jacket temperature of the chemical tank to 65°C to heat the chemical tank, add glycerin, remaining purified water, and sweetener to the chemical tank, stir for 15 minutes until the materials are evenly dissolved, add β-glucan solution, and continue Stir for 10 minutes;

[0035] (3) When the temperature of the material in the chemical...

Embodiment 3

[0038] Example 3 Preparation of Chewable Soft Capsules

[0039] 1. Capsule skin preparation: prepared from the following mass ratio components: gelatin with a freezing strength of 80: glycerin: purified water: sweetener (xylitol): natural flavoring agent (sweet orange powder): β-glucan (Molecular weight 500kD)=35:10:35:5:0.5:2.5:

[0040] (1) Dissolve the natural flavoring agent in purified water with an amount of 18% purified water, mix well, heat to 30~32°C, add β-glucan, continue to stir for 8 minutes, and then place it under ultrasonic wave with a frequency of 55KHz for ultrasonic treatment 20mim, to get β-glucan solution;

[0041] (2) Set the jacket temperature of the chemical tank to 65°C to heat the chemical tank, add glycerin, remaining purified water, and sweetener to the chemical tank, stir for 20 minutes until the materials are evenly dissolved, add β-glucan solution, and continue Stir for 5 minutes;

[0042] (3) When the material temperature in the chemical tank...

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Abstract

The invention discloses capsule skin of chewable soft capsules with immunity enhancing function and soft capsules prepared from the capsule skin. The capsule skin disclosed by the invention is prepared from gelatin, glycerin, purified water, a sweetener, a natural flavouring agent and beta-glucan according to a mass ratio of (25-35) : (10-20) : (25-35) : (5-15) : (0.5-3) : (0.5-5). The preparation process of the capsule skin comprises the following steps: firstly dissolving the flavouring agent in the purified water, mixing with the beta-glucan, carrying out an ultrasonic treatment, mixing the beta-glucan solution with the rest components after the ultrasonic treatment, dissolving, melting the gelatin to obtain a gelatin solution, and preparing the gelatin solution into the capsule skin via a conventional process. By adopting the formula of the capsule skin disclosed by the invention, the capsule skin prepared by the preparation method has high chewiness, stability and moisture retention property, the ultrasonic treatment can balance the rubber smell and the content taste and can exert the immunity enhancing function of the beta-glucan, chewable soft capsules prepared from the capsule skin have good softness, chewiness and taste, after the capsule skin is broken, the capsule skin can be quickly dissolved or dispersed, thereby being easy to swallow.

Description

technical field [0001] The invention relates to a capsule skin of a chewable soft capsule, in particular to a capsule skin of a chewable soft capsule with an immune-enhancing effect and a soft capsule prepared therefrom, belonging to the technical field of medicine, food, health food or pharmacy. Background technique [0002] Chewable soft capsules are soft capsules that can be chewed. Compared with traditional capsule preparations, chewable soft capsules have good chewability and are easy to take. They are popular with the elderly, children and patients who are difficult to swallow traditional soft capsules. like. [0003] With the development of technology, chewable soft capsules are gradually moving closer to the field of health care products and are used in many fields. Existing soft capsules and their preparation have the following deficiencies: (1) the chewability is not ideal, and the stability is relatively poor; at present, it is mainly increased by adding plastici...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K47/36A23P1/04
Inventor 梅丹陈文俊
Owner 安徽钙尔奇生物医药有限公司
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