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Method for preparing black sesame formula granules

A technology of formula granules and black sesame, which is applied in the direction of pharmaceutical formulas, medical preparations containing active ingredients, block transportation, etc., can solve problems such as difficult forming, and achieve simple production processes, increased production capacity, and strong quality controllability Effect

Inactive Publication Date: 2015-06-10
BEIJING KANGRENTANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to disclose a black sesame formula granule; the purpose of the present invention is also to disclose the improvement process of the granulation process of the formula granule, which solves the problem that the traditional Chinese medicine with more oil content is not easy to form during the granulation process

Method used

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  • Method for preparing black sesame formula granules
  • Method for preparing black sesame formula granules

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0030] Embodiment 1: black sesame formula granules

[0031] The extraction process adopts the basket-type dynamic circulation extraction technology, water is used as the extraction solvent, black sesame decoction pieces are taken, and the black sesame is decocted for the second time to extract, the first decoction is added with 12 times the weight of water, and the extraction is 1.5 hours; after the first decoction, the dregs of the medicine are added to the black sesame The decoction pieces are extracted with 10 times the weight of water for 1 hour, that is, the second decoction; the two decoctions are combined, and concentrated under reduced pressure and vacuum to a concentrated solution with a relative density of 1.05-1.10.

[0032] The granulation process uses spray drying followed by a one-step fluidized granulation method.

[0033] The spray drying process parameters are: liquid medicine preheating temperature: 54-60°C, spray tower inlet air temperature: 165-170°C, spray...

Embodiment 2

[0040] Embodiment 2: black sesame formula granules

[0041] The extraction process adopts the basket-type dynamic circulation extraction technology, water is used as the extraction solvent, black sesame decoction pieces are taken, and the black sesame is extracted for the second decoction, adding 10 times the weight of water for the first decoction, and extracting for 3 hours; after the first decoction, add the black sesame The decoction pieces are extracted with 8 times the weight of water for 2 hours, that is, the second decoction; the two decoctions are combined, and concentrated under reduced pressure and vacuum to a concentrated solution with a relative density of 1.05-1.10.

[0042] The granulation process uses spray drying followed by a one-step fluidized granulation method.

[0043] Spray drying process parameters are: liquid preheating temperature: 50-55°C, spray tower inlet air temperature: 165-168°C, spray tower outlet air temperature: 60-67°C, spray tower atomizer ...

Embodiment 3

[0050] Embodiment 3: black sesame formula granules

[0051]The extraction process adopts the basket type dynamic circulation extraction technology, and water is used as the extraction solvent. Take the black sesame decoction pieces, decoct the black sesame for the second time to extract, add 12 times the weight of water to the first decoction, extract for 2 hours; ; Merge the two decoctions, decompress and vacuum concentrate to a concentrated solution with a relative density of 1.05-1.10.

[0052] The granulation process uses spray drying followed by a one-step fluidized granulation method.

[0053] Spray drying process parameters are: liquid preheating temperature: 50-56°C, spray tower inlet air temperature: 165-170°C, spray tower outlet air temperature: 62-70°C, spray tower atomizer frequency: 260-265Hz, Spray tower feed pump frequency: 30-35Hz, to obtain 120 mesh black sesame spray-dried powder.

[0054] Adhesive preparation steps:

[0055] a. Put dextrin in a bucket, a...

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Abstract

The invention discloses a method for preparing black sesame formula granules, and belongs to the technical field of traditional Chinese medicine preparations. The method comprises an extraction process and a granulation process, the extraction process comprises: adopting a basket type dynamic circulation technology, and using water as an extraction solvent, carrying out twice frying extraction on black sesame, mixing the extracting solutions, and carrying out vacuum concentration; the granulation process comprises: adopting spray drying and one-step fluidized-bed granulation process to prepare black sesame formula granules, spray drying 1 / 20 to 1 / 4 dry powder obtained by spray drying to prepare an adhesive, and using the remaining 3 / 4 to 19 / 20 dry powder as a further granulation substrate to carry out one-step granulation. The preparation method disclosed by the invention is simple in process, high in yield and is suitable for industrial production; and each gram of black sesame formula granules is equivalent to 10-20g of crude medicine dosage.

Description

technical field [0001] The invention relates to a traditional Chinese medicine formula granule and a preparation method thereof, in particular to an improvement of an extraction and granulation process of a black sesame formula granule, which belongs to the field of traditional Chinese medicine preparations. Background technique [0002] Black sesame, also known as black sesame, flax, jusheng, etc., is a plant of the genus Sesama in the family Sesamaceae (Linaceae). Sesamum indicum L. The dry and mature seeds of the species are black on the surface, flat oval, smooth or wrinkled, and have brown dotted hilums at the tip. They are produced in Shandong, Hebei, Henan, Sichuan, Anhui, Jiangxi, Hubei and other places in my country. Black Sesame is a traditional Chinese medicine for nourishing the liver and kidney in our country. It has great medicinal value. Traditional Chinese medicine and health experts often use it as a medicinal diet to treat some diseases. [0003] The prepa...

Claims

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Application Information

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IPC IPC(8): A61K36/185A61K9/16A61P1/14
Inventor 孙娜康伟
Owner BEIJING KANGRENTANG PHARMA
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