Preparation technology of cefotaxime sodium sulbactam sodium for injection

A technology for cefotaxime sodium and sulbactam sodium and cefotaxime sodium is applied in the field of preparation technology of cefotaxime sodium and sulbactam sodium for injection, and can solve the problems of introducing impurities into cefotaxime sodium and sulbactam sodium.

Inactive Publication Date: 2015-07-22
SICHUAN PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The technical problem to be solved by this invention is to provide a kind of preparation technology of cefotaxime sodium sulbactam sodium for injection, to overcome the preparation technology of existing cefotaxime sodium sulbactam sodium for injection which easily leads to cefotaxime sodium for injection The problem of introducing impurities into oxime sodium sulbactam sodium

Method used

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Embodiment

[0021] The preparation technology of cefotaxime sodium sulbactam sodium for injection comprises the following steps:

[0022] (1) Synthesis of cefotaxime sodium and sulbactam sodium: cefotaxime sodium and sulbactam sodium are prepared in a weight ratio of 1:0.8, and both cefotaxime sodium and sulbactam sodium are pulverized into granules by nano pulverizer The diameter is 3000nm;

[0023] (2) Mix the prepared fotaxime sodium sulbactam sodium with a mixer;

[0024] (3) The preparation process of cefotaxime sodium sulbactam sodium: firstly, the reagent bottle used to hold cefotaxime sodium sulbactam sodium powder is cleaned, and the cleaning process of the reagent bottle is ultrasonic washing, 80 ℃ hot water immersion 60min, then rinse with warm water at 25°C, air-dry, oven-dry, and dry-heat sterilize, then put cefotaxime sodium sulbactam sodium powder into the above-mentioned cleaned reagent bottle according to the specification and fill it with nitrogen, Then cover the pretr...

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Abstract

The invention relates to a preparation technology of cefotaxime sodium sulbactam sodium for injection. The preparation technology comprises the following steps: (1) synthetizing the cefotaxime sodium sulbactam sodium, compounding cefotaxime sodium and sulbactam sodium according to the weight ratio of 1: (1.3-1): 0.14, and crushing the cefotaxime sodium and the sulbactam sodium through a crusher until the particle diameter is 1800-5000nm; (2) uniformly mixing the compounded cefotaxime sodium sulbactam sodium through a material mixing machine; (3) the preparation technology of the cefotaxime sodium sulbactam sodium comprises the following steps: firstly, cleaning a reagent bottle for containing cefotaxime sodium sulbactam sodium powder, wherein the cleaning process of the reagent bottle successively comprises the steps of ultrasonically washing the reagent bottle, soaking the reagent bottle in hot water of 80-100 DEG C for 30min-60min, flushing the reagent bottle with warm water of 25 DEG C, drying the reagent bottle with air, drying the reagent bottle with an oven, and sterilizing the reagent bottle. The preparation technology disclosed by the invention solves the problem that a conventional preparation technology of the cefotaxime sodium sulbactam sodium for injection is easy to causeimpurities to enter the cefotaxime sodium sulbactam sodium for injection.

Description

technical field [0001] The invention relates to the field of preparation technology of medical drugs, in particular to a preparation technology of cefotaxime sodium sulbactam sodium for injection. Background technique [0002] Cefotaxime sodium sulbactam sodium is a compound preparation of cefotaxime sodium and sulbactam sodium, and it is a drug with stable active ingredient content for the treatment of drug-resistant bacterial infections such as NDM-1-producing 'super bacteria' combination. NDM-1 is the English abbreviation of New Delhi metallo-beta-lactamase-1. It was reported by an article published in the famous British medical journal on August 11, 2010. Because the bacteria carrying this gene will produce a special beta-lactamase Lactamase, and the active site is a metal ion, and it first appeared in New Delhi, India, so it was named NDM-1. The bacteria that produce NDM-1 are generally Escherichia coli and Klebsiella pneumoniae. These bacteria can cause nosocomial in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/546A61P31/04A61K31/43
Inventor 周璇沈千万刘萍
Owner SICHUAN PHARMA
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