Application of nicotinamide mononucleotide in preparation of anti-aging drugs or health care products

A single nucleotide and nicotinamide technology, applied in application, food preparation, drug combination, etc., can solve the problems of poor efficacy, toxic side effects, high cost, etc., and achieve the effect of easy and stable efficacy, obvious efficacy and high safety

Inactive Publication Date: 2015-08-05
BONTAC BIO ENG SHENZHEN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In view of the above-mentioned deficiencies in the prior art, the purpose of the present invention is to provide the application of nicotinamide mononucleotide in the preparation of anti-aging drugs or health products, aiming to solve the problems of poor efficacy, high cost, and high cost of existing anti-aging drugs or health products. and the problem of toxic side effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Example 1: Application of Nicotinamide Mononucleotide in the Preparation of Anti-aging Drugs or Health Products

[0022] Various dosage forms are prepared by using conventional methods in the field of medicine and health care products, and pharmaceutically acceptable auxiliary materials. When used for oral administration, it can be prepared into conventional solid preparations such as tablets, powders or capsules, etc.; when used for injection, it can be prepared as injection solution.

[0023] (1) Weighing: 10 grams of food grade NMN;

[0024] 40 grams of D-mannitol; 20 grams of microcrystalline cellulose;

[0025] (2) Mix and compress: add 0.5 g of magnesium stearate, mix and compress;

[0026] (3) Coating: Use 2.5 grams of isolation coating and 8 grams of enteric coating solution;

[0027] (4): Tablet packaging.

Embodiment 2

[0028] Embodiment 2: pharmacodynamic experiment

[0029] Materials and methods

[0030] 1.1 Experimental materials: Nicotinamide mononucleotide (NMN),

[0031] 1.2 Experimental animals: Kunming mice (about 52 weeks old)

[0032] 1.3 Administration method:

[0033] Blank group: given normal diet;

[0034] Treatment group: NMN (including excipients) completely dissolved in water was added to the general diet, and the single dose of NMN was 20 mg / kg body weight / day;

[0035] Control group: Add the same amount of auxiliary materials as the treatment group in the general diet;

[0036] Mouse survival experiment: 120 52-week-old mice were randomly divided into two groups (blank control group and treatment group), 40 in each group.

[0037] Experimental method: refer to the functional evaluation procedure and test method specification of health food (Ministry of Health, 2003 edition).

[0038] Table 1 Results of mouse survival experiment

[0039] Experimental group ...

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PUM

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Abstract

The invention discloses application of nicotinamide mononucleotide in preparation of anti-aging drugs or health care products, wherein nicotinamide mononucleotide is applied to preparation of anti-aging drugs or health products. The nicotinamide mononucleotide (NMN) provided by the invention is used as an active ingredient in preparation of anti-aging drugs or health products. The specific dose can be decided according to the severity degree of diseases, drug delivery approaches and related factors. NMN itself is a body intracellular substance, has high safety as a drug or health product, and the NMN is a monomer molecule, the efficacy is obvious and stable.

Description

technical field [0001] The invention relates to the application field of NMN, in particular to the application of nicotinamide mononucleotide in the preparation of anti-aging drugs or health care products. Background technique [0002] With the continuous improvement of people's living standards, people's desire to pursue health and longevity is becoming stronger and stronger. However, aging is an inevitable law in any life process, and it is a biological law independent of human will. However, it is possible to slow down the speed of aging and make people's lifespan reach the maximum lifespan endowed by nature. Most of the domestic anti-aging drugs or health care products come from traditional Chinese medicine compound. For example, Qi Jianhua et al. (2012, authorized patent number CN 102247524 B) found that the extraction of total steroidal saponins of Ophiopogon japonicus has anti-aging effects. Due to the complex composition of traditional Chinese medicine, its efficacy...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/706A61P39/00A23L1/30
CPCA61K9/28A61K31/706A61K47/26A61K47/38A61P39/00
Inventor 傅荣昭张琦
Owner BONTAC BIO ENG SHENZHEN
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