A method for the detection of six phthalates in drinking water by liquid chromatography-mass spectrometry

A phthalate ester and liquid mass spectrometry technology, applied in the field of detection and drinking water detection, can solve the problems of qualitative and quantitative analysis of phthalate esters that have not yet been seen, and achieve low cost, simple and convenient operation, and blank low value effect

Inactive Publication Date: 2017-03-15
桂林市环境监测中心站
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But at present, there is no report on the qualitative and quantitative analysis of six phthalates in drinking water by HPLC-MS

Method used

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  • A method for the detection of six phthalates in drinking water by liquid chromatography-mass spectrometry
  • A method for the detection of six phthalates in drinking water by liquid chromatography-mass spectrometry
  • A method for the detection of six phthalates in drinking water by liquid chromatography-mass spectrometry

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] (1) Install a guard column: install a guard column in series with a connecting tube at the front end of the chromatographic column. The inlet of the guard column is connected to the injection port, and the outlet is connected to the chromatographic column. There are hollow screws and pressure rings for sealing at both ends of the connecting tube;

[0035] (2) Determination conditions and methods: get 6 kinds of standard solutions whose concentration of phthalates is 200 μg / mL, measure with liquid chromatography-tandem quadrupole mass spectrometry, instrument parameter conditions are shown in Table 3, select reaction monitoring Precursor ions, product ions and collision energy are shown in Table 2; 2mL8mm standard screw-top sample vials were used for the determination of samples, and only bottle caps were used for sample analysis;

[0036] Table 3 Instrument parameters of liquid chromatography-tandem quadrupole mass spectrometry

[0037]

[0038]

[0039]Table 2 Se...

Embodiment 2

[0049] (1) Install a guard column: install a guard column in series with a connecting tube at the front end of the chromatographic column. The inlet of the guard column is connected to the injection port, and the outlet is connected to the chromatographic column. There are hollow screws and pressure rings for sealing at both ends of the connecting tube;

[0050] (2) Determination conditions and methods: get 6 kinds of standard solutions whose phthalates concentration is 200 μg / mL, measure with liquid chromatography-tandem quadrupole mass spectrometry, instrument parameter conditions are shown in Table 5, select reaction monitoring Precursor ions, product ions and collision energy are shown in Table 2; 2mL8mm standard screw-top sample vials were used for the determination of samples, and only bottle caps were used for sample analysis;

[0051] Table 5 Instrument parameters of liquid chromatography-tandem quadrupole mass spectrometry

[0052]

[0053] Table 2 Selection of rea...

Embodiment 3

[0064] (1) Install a guard column: install a guard column in series with a connecting tube at the front end of the chromatographic column. The inlet of the guard column is connected to the injection port, and the outlet is connected to the chromatographic column. There are hollow screws and pressure rings for sealing at both ends of the connecting tube;

[0065] (2) Determination conditions and methods: get 6 kinds of standard solutions whose concentration of phthalates are 200 μg / mL, measure with liquid chromatography-tandem quadrupole mass spectrometry, instrument parameter conditions are shown in Table 7, select reaction monitoring Precursor ions, product ions and collision energy are shown in Table 2; 2mL8mm standard screw-top sample vials were used for the determination of samples, and only bottle caps were used for sample analysis;

[0066] Table 7 Instrument parameters of liquid chromatography-tandem quadrupole mass spectrometry

[0067]

[0068]

[0069] Table 2 Se...

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PUM

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Abstract

The invention discloses a method for detecting six phthalates in drinking water through liquid chromatography-mass spectrometry, and belongs to the technical field of drinking water detection. The method comprises the following steps: (1) additionally arranging a protection column; (2) measuring conditions and a mode; (3) establishing a standard working curve; (4) detecting to-be-detected drinking water. According to the detection method, a sample is not required to be pretreated and can be directly fed, so that the six phthalates (DMP (Dimethyl Phthalate), DEP (Diethyl Phthalate), DBP (Dibutyl Phthalate), BBP (Benzyl Butyl Phthalate), DEHP (Di 2-Ethyl Hexyl Phthalate) and DNOP (Di N Octyl Phthalate)) in the drinking water are qualitatively and quantitatively analyzed at high speed; the method has the advantages of easiness and convenience in operation, less sampling quantity, low cost, good reproducibility, high stability and the like, is not only suitable for daily environment monitoring and is also suitable for quick screening of pollutants in emergency accidents.

Description

technical field [0001] The invention relates to a detection method, in particular to a simple and fast qualitative and quantitative detection method for six phthalates in drinking water, belonging to the technical field of drinking water detection. Background technique [0002] Phthalic acid esters (PAEs) are an important class of endocrine disruptors. Trace amounts of PAEs will be enriched in water, soil, animals and plants, difficult to degrade in the environment, interfere with the endocrine system of the human body, and directly affect the metabolism of the human body. The plasticizer bis(2-ethylhexyl) phthalate Ester (DEHP) is 20 times more toxic than melamine. Studies have shown that plasticizers can also increase the burden on the liver and kidneys, cause chronic damage to the immune system and digestive system, and even lead to liver cancer. In the liquor incident in 2012, the highest detection value of dibutyl phthalate (DBP) in the sample was 1.04mg / kg. With the...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02
Inventor 张志朋彭靖恺杜娟宋韶华黎泳珊李常丽邹志勇黄跃武易春盛计晓梅
Owner 桂林市环境监测中心站
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