Monoammonium glycyrrhizinate sustained release preparation and preparation method thereof

Abstract

The invention discloses a monoammonium glycyrrhizinate sustained release preparation and a preparation method thereof. The monoammonium glycyrrhizinate sustained release preparation comprises 100 parts of monoammonium glycyrrhizinate, 50-1000 parts of a sustained release auxiliary material, 1-5 parts of a lubricant, 20-100 parts of a diluent and 50-200 parts of an adhesive. The preparation method has the advantages of simple steps and convenient operation. The monoammonium glycyrrhizinate sustained release preparation has the characteristics of slow release of a drug at a proper speed, small fluctuation of the peak valley of the blood drug concentration, avoiding of toxic side effects due to exceeding of a treatment blood drug concentration range, and maintenance of an effective concentration range for a long time; and compared with common preparations, the sustained release preparation has the advantages of prolongation of the lasting time of the treatment effect, toxic side effect reduction, reduction of the drug use frequency, and improvement of the use compliance of the drug.

Description

technical field [0001] The invention relates to a sustained-release preparation of monoammonium glycyrrhizinate and a preparation method thereof, belonging to the technical field of pharmaceutical dosage forms and preparation thereof. Background technique [0002] Licorice has a long history of medicinal use in my country. It has the functions of clearing heat and detoxification, antibacterial and anti-inflammatory, and can relieve drug poisoning, food poisoning, and poisoning of metabolites in the body. The active ingredient of licorice is glycyrrhizic acid, and preparations for glycyrrhizic acid and its salts have been well researched and developed in recent years. At present, the ammonium salt of glycyrrhizic acid is the most widely used in the market. The ammonium salt of glycyrrhizic acid has anti-inflammatory and anti-allergic effects, and can effectively inhibit and fight inflammatory reactions; it has obvious inhibitory effects on various acute and chronic inflammat...

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Problems solved by technology

[0003] The treatment cycle for liver disease is long, ranging from 6 months to several years. Sometimes repeated long-term medication is required for repeated liver disease. In addition, common liver disease medication needs to be taken 3 times a day, which brings inconvenience to long-term medication patients and easily leads to Forgetting to take the medicine on time leads to lack of regularity, and too many times of taking the medicine often causes the concentration of the medicine to fluctuate greatly in the body, leading to hidden dangers of medication safety. Improper medication will not only fail to achieve therapeutic effect, but will cause damage to the liver

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