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Pharmaceutical preparation for preventing and treating epilepsy and application thereof

A pharmaceutical preparation and epilepsy technology, applied in the field of medicine, can solve problems such as lowering of intelligence level, and achieve the effects of lowering activity, simple preparation method, and prolonging the latency period of epileptic seizures.

Inactive Publication Date: 2015-08-19
周玉梅
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In particular, epilepsy patients often show a decrease in intelligence level, and the cognitive toxicity of existing antiepileptic drugs is undoubtedly worse for epilepsy patients, especially adolescent patients

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] Embodiment 1: the preparation of Chinese medicine dry plaster powder

[0015] Weigh 5.0kg of peanut leaves, 1.8kg of capillary wormwood, 1.3kg of Achyranthes bidentata, 0.5kg of Chuanxiong, 0.5kg of peach blossom, and 7.2kg of kelp, add water to decoct twice, add 180L of purified water for the first time, decoct for 2 hours, and decoct for the second time Add 160L of purified water once, decoct for 1.5h, combine the decoctions, concentrate under reduced pressure at 0.08MPa and 70°C until the relative density is 1.15 at 70°C, add 95% ethanol to make the alcohol content reach 75% (v / v), Stir, stand overnight, filter, and concentrate the filtrate under reduced pressure at 0.08MPa and 65°C to obtain an extract with a relative density of 1.25 at 65°C, put the extract in a stainless steel plate, and vacuum dry (below 60°C) to become a dry paste , crushed.

Embodiment 2

[0016] Embodiment 2: the preparation of Chinese medicine preparation

[0017] Chinese herbal extract 1kg

[0018] Dextrin 2.0kg

[0019] Sucrose 0.8kg

[0020] Talc powder 0.03kg

[0021] 75% ethanol solution appropriate amount

[0022] Preparation method: Weigh the dry powder of traditional Chinese medicine extract (prepared according to the formula process of Example 1) in the prescribed amount, pass through 100 mesh to dry, then add dextrin and sucrose passed through 80 mesh sieve, mix evenly, and add an appropriate amount of 75% The ethanol solution is used as a binder, and wet granulation is adopted, that is, the wet granules are made through a 32-mesh sieve, and the wet granules are fully dried at 45-60°C, and the granules are sized. The dry granules are added with talcum powder, mixed evenly, and packed separately to obtain traditional Chinese medicine granules. Dosage (10g per pack).

Embodiment 3

[0023] Example 3: Study on the Treatment of Epilepsy Model Mice with Dry Paste Powder of Traditional Chinese Medicine

[0024] 48 healthy male Kunming mice, weighing 18-22g, were randomly divided into the following six groups after adapting to the environment for 3 days: normal control group, model control group, low-dose Chinese medicine group, and high-dose Chinese medicine group. 12 only. Except the normal control group, the other 3 groups were used to establish the epilepsy model, and the method was as follows: before the first administration, pentetrazol (50 mg / kg) was injected intraperitoneally according to body weight. Beginning on the second day after the injection, for 10 consecutive days, the mice in each group were given the test substance (administration volume 0.3-0.4m1) by gavage in the morning, noon and evening every day, and the Chinese medicine low and high dose groups were respectively given the Chinese medicine prepared in Example 1 Dry paste powder 270, 81...

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Abstract

The invention discloses a pharmaceutical preparation for preventing and treating epilepsy and application thereof. The pharmaceutical preparation is composed of an active component and pharmaceutically acceptable auxiliary materials, wherein the active component is prepared from the following traditional Chinese medicine raw materials in parts by weight through a water-extraction and alcohol-precipitation method: 40-60 parts of peanut leaves, 12-25 parts of oriental wormwood, 9-18 parts of the root of bidentate achyranthes, 3-6 parts of lgusticum wallichii, 3-6 parts of peach blossom, and 60-90 parts of kelps. Animal experiments and clinical application researches show that the pharmaceutical preparation disclosed by the invention has the obvious promoting effect of prolonging anepileptic seizure incubation period, negatively controlling the activity of NOS and reducing the content of NO.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a drug preparation for preventing and treating epilepsy and its application. Background technique [0002] Epilepsy is a brain disorder characterized by the persistence of permanent changes in the brain that produce seizures, with corresponding neurobiological, cognitive, psychological, and sociological consequences. There are about 70 million epilepsy patients in the world, of which more than 90% are located in low- and middle-income countries. The incidence rate is second only to migraine, stroke, and Alzheimer's disease, and it has become a common chronic disease that can affect people of all ages. especially in childhood and adolescence. According to epidemiological surveys, the prevalence of epilepsy is increasing year by year, causing great harm and impact on individuals, families, and society. At present, epilepsy has become a complex neurological disease tha...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/736A61P25/08
Inventor 周玉梅
Owner 周玉梅
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