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Medical composition for facilitating repair of hematopoietic damage
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A technology of hematopoietic injury and composition, which is applied in the medical field and can solve the problems of fast recovery of white blood cell count and other problems
Inactive Publication Date: 2015-08-26
EAST CHINA UNIV OF SCI & TECH
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Liu Changsheng and others found that rhBMP-2 fusion protein has an effective therapeutic effect on hematopoietic injury caused by radiotherapy and chemotherapy, but the recovery speed of its white blood cell count is not as fast as that of granulocyte colony-stimulating factor
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Embodiment 1
[0081] Synergistic effect of recombinant human bone morphogenetic protein-2 (rhBMP-2) and granulocyte-stimulating factor (G-CSF) in the repair of hematopoietic injury induced by radiotherapy drugs
[0082] The purpose of this example is to observe the synergistic effect of rhBMP-2 and G-CSF on the therapeutic recovery of peripheral blood leukocytes, erythrocytes, hemoglobin, and thrombocytopenia caused by chemotherapy drugs, so as to find a clinically fast and stable Improve the new system of therapeutic drugs against chemotherapy damage.
[0083] Material
[0084] Recombinant human bone morphogenetic protein-2: rhBMP-2 (refer to CN200910045832 preparation, SEQ ID NO: 2);
[0087] SPF grade C57BL / 6 mice, male, 6-8 weeks old, 18-20 g, were randomly divided into 20 mice in each group.
[0088] The experimental group...
Embodiment 2
[0120] Synergistic effect of recombinant human bone morphogenetic protein (rhBMP-2) and granulocyte-stimulating factor (G-CSF) in the repair of hematopoietic damage induced by radiation therapy
[0121] The purpose of this example is to observe the synergistic effect of rhBMP-2 and G-CSF on the therapeutic recovery of red blood cells, hemoglobin, and thrombocytopenia caused by radiotherapy rays.
[0124] Granulocyte-stimulating factor: commercialized recombinant human granulocyte-stimulating factor injection (trade name Jirifen)
[0125] method
[0126] SPF grade C57BL / 6 mice, male, 6-8 weeks old, 18-20 g, were randomly divided into 20 mice in each group.
[0127] The experimental groups are as follows:
[0128] Except for the normal control group, mice in each group were irradiated with X-rays all over the body at one time, with a total dose of 6.0Gy, a dose rate of 1.09Gy / min, and an irra...
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Abstract
The invention discloses a medical composition for facilitating repair of hematopoietic damage. The medical composition comprises recombinant human bone morphogenetic protein-2 and human granulocyte stimulating factors, through the favorable synergistic reaction of the recombinant human bone morphogenetic protein-2 and the human granulocyte stimulating factors, recovery of hematopoietic stem cells, functional cells of a spleen and functional cells of a thymus during the hematopoietic damage can be effectively facilitated, the recovery of blood cells of peripheral blood when a hematopoietic function is poor can also be facilitated, the recovery of white blood cells of the peripheral blood during bone marrowtransplantation can be accelerated, and the medical composition can be used as a medicine for preventing and / or treating the hematopoietic damage and a mobilizing agent for transplantation of stem cells of the peripheral blood.
Description
technical field [0001] The present invention relates to the field of medicine, in particular to a pharmaceutical composition for promoting the repair of hematopoietic damage, in particular to a composition comprising recombinant human bone morphogenetic protein-2 (bone morphogenetic protein, rhBMP-2) and human granulocyte-stimulating factor (rhG-CSF) The composition is used for promoting the repair of hematopoietic damage. Background technique [0002] In recent years, the incidence of malignant tumors, acute radiation sickness and various blood diseases caused by environmental pollution, chemical pollution, ionizing radiation and other factors has been increasing worldwide. At present, radiotherapy and chemotherapy are mainly used to treat tumors. Bone marrow suppression is one of the most common side effects of radiotherapy and chemotherapy. However, when the body is irradiated with lethal doses of radiation or receives a considerable dose of chemotherapy drugs, it will le...
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