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Traditional Chinese medicine preparation for preventing contrast associated nephropathy as well as preparation method

A technology of traditional Chinese medicine preparations and medicinal materials, which is applied in the field of traditional Chinese medicine preparations and preparations for the prevention of contrast-mediated nephropathy, which can solve the problems of only 0.6% to 1.25% and achieve the effects of small toxic and side effects and preventive curative effect

Inactive Publication Date: 2015-09-09
牛灵芝
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in a group of retrospective multiple myeloma observations after receiving contrast agents, the incidence of CAN was only 0.6% to 1.25%.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0047] When the dosage form of described Chinese medicine preparation is tablet, its preparation method comprises the following steps:

[0048] The first step is to mix the raw materials of the traditional Chinese medicine preparation in proportion, add ethanol with an alcohol concentration of 85-95% that is 2-4 times the mass of the mixture, heat and reflux for 1-3 hours, extract, and filter to obtain the first extraction. liquid; the medicinal dregs obtained by filtering are then added with ethanol having an alcohol concentration of 1 to 2 times the mass of the medicinal dregs and are 85 to 95% ethanol, heated and refluxed for 1 to 3 hours, extracted, and filtered to obtain a second extract; the first The extract and the second extract are combined, concentrated under reduced pressure to remove the ethanol solvent, and dried to obtain a dry paste;

[0049] In the second step, the dry paste obtained in the first step is placed in an ultrafine pulverizer for 1 to 2 hours, pulv...

Embodiment 1

[0056] Embodiment 1: tablet

[0057] Take 60g of white sandalwood, 190g of cypress root, 120g of mussel orchid leaf, 90g of baoqi, 150g of flat fruit, 140g of fenxin wood, 280g of chicken egg grass, 170g of golden silk vine, 240g of human head seven, 110g of heather leaf, 200g of pig hair needle, 210g of wild beans, 140g of Yedizhu, 200g of purple shoot flowers, 250g of bamboo orchid grass, 190g of rough yellow grass, 280g of horned orchid and 240g of Panlong ginseng.

[0058]Its preparation method comprises the following steps:

[0059] The first step is to mix the raw materials of the traditional Chinese medicine preparation in proportion, add ethanol with an alcohol concentration of 95% that is three times the mass of the mixture, heat and reflux for 3 hours, extract, and filter to obtain the first extract; The dregs are then added with ethanol with an alcohol concentration of 95% that is twice the mass of the dregs, heated to reflux for 3 hours, extracted, and filtered to...

Embodiment 2

[0062] Embodiment 2: capsules

[0063] Take 80g of white sandalwood, 160g of cypress root, 130g of clam orchid leaves, 70g of baoqi, 180g of flat fruit, 120g of fenxin wood, 260g of chicken egg grass, 190g of golden silk vine, 180g of human head seven, 130g of heather leaves, 170g of pig hair needles, 250g of wild beans, 110g of Yedizhu, 230g of purple shoot flowers, 280g of bamboo orchid grass, 150g of rough yellow grass, 330g of horned orchid and 220g of Panlong ginseng.

[0064] Its preparation method comprises the following steps:

[0065] The first step is to mix the raw materials of the traditional Chinese medicine preparation in proportion, add ethanol with an alcohol concentration of 85% that is 4 times the mass of the mixture, heat and reflux for 3 hours, extract, and filter to obtain the first extract; Add ethanol with an alcohol concentration of 95% to the dregs, which is twice the mass of the dregs, heat and reflux for 3 hours, extract, and filter to obtain the se...

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PUM

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Abstract

The invention provides a traditional Chinese medicine preparation for preventing contrast associated nephropathy as well as a preparation method. The traditional Chinese medicine preparation comprises raw materials as follows: sandalwood, cypress roots, herb of siebold buttercup, roots of Dysosma difformis, Terminthia peniculata, Semen Juglandis, Habenaria tenaculata Reichb, Parameria laevigata, Herminium monorhis(L.)R.Br., Chinese photinia leaves, Adiantum capillus junosis Rupr., wild soybean, Flueggea suffruticosa, freshwater sponge, all-grass of bulley herminium, Dendrobium densiflorum Lindl ex Wall, Herminium monorchis and Radix seu Spiranthis Lanceae. The traditional Chinese medicine preparation has the benefits of definite curative effect on prevention of contrast associated nephropathy as well as little toxic and side effects.

Description

technical field [0001] The invention relates to a medical preparation containing components derived from plants, animals or minerals, in particular to a traditional Chinese medicine preparation and a preparation method for preventing contrast nephropathy. Background technique [0002] With the widespread development of modern imaging techniques, contrast associated nephropathy (CAN) has drawn increasing attention from nephrologists. CAN refers to a sudden decrease in renal function caused by contrast media. Commonly used contrast agents are generally hypertonic, with iodine content as high as 37%. In the body, they are filtered by the glomeruli in their original form and not absorbed by the renal tubules. When dehydrated, the concentration of the drug in the kidney increases, which can cause kidney damage. Acute renal failure occurs. Reports of acute renal failure caused by contrast agents are increasing day by day, and even its incidence exceeds that caused by aminoglycos...

Claims

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Application Information

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IPC IPC(8): A61K36/898A61P13/12A61K35/655
Inventor 牛灵芝
Owner 牛灵芝
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