Kit for diagnosing mycobacterium tuberculosis infection based on tuberculosis specificity IL-31 detection

A technology of Mycobacterium tuberculosis and a diagnostic kit, which is applied in the field of biomedicine to achieve the effects of high sensitivity and accuracy, improved sensitivity and specificity, and rapid operation

Inactive Publication Date: 2015-09-09
AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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  • Kit for diagnosing mycobacterium tuberculosis infection based on tuberculosis specificity IL-31 detection
  • Kit for diagnosing mycobacterium tuberculosis infection based on tuberculosis specificity IL-31 detection
  • Kit for diagnosing mycobacterium tuberculosis infection based on tuberculosis specificity IL-31 detection

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Embodiment 1

[0049] In the present embodiment, the method for diagnosing Mycobacterium tuberculosis infection using the above-mentioned diagnostic kit comprises the following steps:

[0050] 1. Collect peripheral whole blood:

[0051] 1.1 Collect peripheral blood samples from patients with tuberculous pleurisy and neoplastic pleural effusion:

[0052] Inclusion criteria for patients with tuberculous pleural effusion: (1) pleural effusion was exudate, negative for common bacterial culture and positive for Mycobacterium tuberculosis; (2) pleural histopathological examination was consistent with tuberculosis. Those who meet one of the above two items are diagnosed with tuberculous pleural effusion; (3) those who meet the clinical manifestations of tuberculous pleural effusion: low fever, night sweats, fatigue, chest tightness, exudative pleural effusion, etc., and those who are effective in anti-tuberculosis treatment , for patients with clinical diagnosis of tuberculous pleural effusion, a ...

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Abstract

The invention provides a kit for diagnosing mycobacterium tuberculosis infection based on tuberculosis specificity IL-31 detection. The kit comprises an IL-31 capture antibody, an IL-31 detection antibody, tuberculosis specific antigen polypeptide, a diluent, a standard substance, a developing solution, a stop solution, a buffer solution, a solid carrier and a micro-plate sealer. The kit is used for detecting the IL-31 expression quantity in plasma, can be used for tuberculosis diagnosis, and is relatively high in sensitivity and accuracy, and fast to operate, so that the diagnosing efficiency of tuberculosis can be improved.

Description

technical field [0001] The invention relates to the field of biomedicine, in particular to a diagnostic kit for using IL-31 to diagnose Mycobacterium tuberculosis infection and a method for using the diagnostic kit to diagnose Mycobacterium tuberculosis infection. Background technique [0002] Tuberculosis is an infectious disease that seriously endangers human health and is currently the chronic infectious disease with the highest mortality rate in the world. In the 1980s, people once believed that the disease had been controlled, but in recent years, the incidence and mortality of tuberculosis have been on the rise. According to the latest report on tuberculosis from the World Health Organization, the current global average number of patients is 14 million. There are 8.8 million new active tuberculosis patients, an average of 1.1 million HIV-negative people died of tuberculosis in 2010, and an average of 350,000 people died of HIV-combined tuberculosis; an infectious tuber...

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Application Information

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IPC IPC(8): G01N33/569
CPCG01N33/5695G01N2333/54G01N2333/7155
Inventor 高岩邵凌云张文宏吴晶张冰琰
Owner AFFILIATED HUSN HOSPITAL OF FUDAN UNIV
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