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Application of traditional Chinese medicine composition in preparation of drugs for treating or preventing yellow fever virus infection

A technology of yellow fever virus and composition, which is applied in antiviral agents, pharmaceutical formulas, plant raw materials, etc.

Inactive Publication Date: 2015-09-23
周耀忠
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

So far, there have been no cases reported in China, but this does not make us relax our vigilance against the virus, because China's climate and geographical environment are complex, and there are many types of mosquitoes, which have the conditions for transmission. At the same time, with the increasing frequency of international exchanges, YFV It is very likely that it will be introduced into China

Method used

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  • Application of traditional Chinese medicine composition in preparation of drugs for treating or preventing yellow fever virus infection
  • Application of traditional Chinese medicine composition in preparation of drugs for treating or preventing yellow fever virus infection

Examples

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Embodiment 1

[0015] Example 1: Take 15g of S. chinensis, 18g of Guojianglong, 20g of Chenopodium chinensis, 15g of chicken feet, 20g of clover, and 15g of Baiyunhua root. 10 times the amount, decocted for 2 hours, the amount of water added for the second time was 8 times the weight of the medicinal material, decocted for 1 hour, combined the decoction, concentrated, dried, and pulverized to obtain Chinese medicine composition granules. The concentration conditions are: 0.07MPa, 60 Concentrate under reduced pressure at -70°C to 65°C with a relative density of 1.30. The spray-drying conditions are: the inlet air temperature is 120°C, the outlet air temperature is 80°C, the material temperature is 90°C, the atomization pressure is 0.4 MPa, and the spray speed is 10ml / s.

Embodiment 2

[0016] Embodiment 2: The toxicity experiment of Chinese medicine composition to Vero cell

[0017] 1. Test drug: Prepare the test drug according to the method in Example 1 above.

[0018] 2. Method: Inoculate Vero cells: Vero cells (African green monkey kidney cells) are susceptible cells to YFV. Make a single cell suspension with DMEM medium containing 10% (v / v) fetal calf serum, inoculate 96-well cell culture plates with 1000-10000 cells per well, and inoculate volume 100ul in each well; cultivate Vero cells: in 37 DEG C, 5% (v / v) CO Under culture condition, culture 2 days; Add Chinese medicine composition: absorb and discard the DMEM culture medium in each well, add 100ul to each well with 10% (v / v) The DMEM medium of fetal bovine serum is diluted into the traditional Chinese medicine composition of corresponding concentration (0M, 0.4M, 1.2M, 3.7M, 11M, 33M, 100M, 300M), control hole adds and does not add and contains 10% (v / v) fetal 100ul of DMEM medium with bovine seru...

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Abstract

The invention discloses application of a traditional Chinese medicine composition in preparation of drugs for treating or preventing yellow fever virus infection. The traditional Chinese medicine composition is prepared by extracting 15 parts of lysimachia decurrens, 18 parts of stem of climbing entada, 20 parts of chenopodium hybridum, 15 parts of desmos chinensis, 20 parts of tetrastigma hemsleyanum and 15 parts of heracleum repula and can effectively inhibit yellow fever virus multiplication, has a very small toxic effect on cells and a wide application prospect and realizes remarkable progress.

Description

technical field [0001] The invention relates to the new application of the traditional Chinese medicine composition, in particular to the application of the traditional Chinese medicine composition in the preparation of medicines for treating or preventing yellow fever virus infection. Background technique [0002] Yellow fever virus (YFV) is a member of the Flavivirus genus in the family Flaviviridae. Yellow fever virus causes yellow fever, an acute infectious disease. Yellow fever has been designated as a quarantine infectious disease internationally, and China has also designated it as a Class A infectious disease. In 1648, an epidemic of yellow fever was first confirmed in the weekly YUCATAN peninsula. From the 17th to the 19th century, the disease was brought to Europe and North America through transportation. Within two centuries, yellow fever became one of the most serious plagues in some parts of the United States, Africa, and Europe, causing a large number of deat...

Claims

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Application Information

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IPC IPC(8): A61K36/87A61P31/14
CPCY02A50/30
Inventor 周耀忠
Owner 周耀忠
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