Alkaloid salt-type medicine for treating psoriasis and preparation method thereof

A preparation process and technology of alkaloids, which are applied in the directions of drug combination, drug delivery, and medical preparations containing active ingredients, etc., can solve the problems of telangiectasia, long medication time for psoriasis, and easy recurrence.

Inactive Publication Date: 2015-10-14
黄冠华 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Various treatments for psoriasis can only achieve short-term curative effect, not cure
The first is the treatment of glucocorticoid drugs, such as mometasone gluconate ointment, clofluxasone cream, super powerful betamethasone propionate, 5% to 10% salicylic acid ointment, 0.1% to 0.5 %Anthralin ointment, etc., long-term use can cause toxic side effects and adverse reactions such as skin atrophy, telangiectasia, and pigmentation
Traditional Chinese medicine takes a long time to treat psoriasis, and the treatment effect is slow. It can only be effective, but it cannot be cured, and it is easy to relapse

Method used

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  • Alkaloid salt-type medicine for treating psoriasis and preparation method thereof
  • Alkaloid salt-type medicine for treating psoriasis and preparation method thereof
  • Alkaloid salt-type medicine for treating psoriasis and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0013] a. According to the proportion of raw materials, mix 10 grams of Sophora flavescens, 10 grams of Salvia miltiorrhiza, 10 grams of white moss bark, 10 grams of wild chrysanthemum, 10 grams of Artemisia argyi leaves, 5 grams of Chinese tallow, 10 grams of Coptis chinensis, 10 grams of Tujing bark, Fangji 5 grams, 10 grams of Lian Qiancao powder, mix well and put it into a traditional Chinese medicine soaking bag for later use, mix 2 grams of scorpion, 2 grams of centipede, and 5 grams of Chinese gall, and put it into another traditional Chinese medicine soaking bag for later use .

[0014] b. Immerse two traditional Chinese medicine soaking bags in a portion of 500 milliliters of 75% ethanol, seal them, soak for 5 days, stir twice a day, take out the two traditional Chinese medicine soaking bags after five days, let stand, and filter to get Chinese medicine extract A ; soak two traditional Chinese medicine soaking bags in another part of 500 milliliters of 75% ethanol, se...

Embodiment 2

[0017] a. Take 15 grams of Sophora flavescens, 15 grams of Salvia miltiorrhiza, 15 grams of white moss bark, 20 grams of wild chrysanthemum, 20 grams of Artemisia argyi, 10 grams of Cortex Phellodendri, 15 grams of Coptis chinensis, 20 grams of Sophora japonica, 10 grams of Fangji, and 20 grams of Lian Qiancao After the powder is mixed, put it into a traditional Chinese medicine soaking bag for use; mix 5 grams of scorpion, 10 grams of gall, and 5 grams of centipede (with bamboo sticks removed) and put it into another traditional Chinese medicine soaking bag for use.

[0018] b, two traditional Chinese medicine soaking bags are immersed in a portion of 560 milliliters of 65% ethanol, sealed, soaked for 7 days, stirred twice a day, after 7 days, the traditional Chinese medicine soaking bags are taken out, allowed to stand, and filtered to obtain Chinese medicine extract solution A; Immerse the two traditional Chinese medicine soaking bags again in another 560 ml of 65% ethanol, ...

Embodiment 3

[0021] Take 20 grams of Sophora flavescens, 20 grams of Salvia miltiorrhiza, 20 grams of white moss bark, 30 grams of wild chrysanthemum, 30 grams of Artemisia argyi, 15 grams of Cortex Phellodendri, 20 grams of Coptis chinensis, 30 grams of Tujing bark, 15 grams of Fangji, and 30 grams of Lian Qiancao. 10 grams of scorpion, 15 grams of Chinese gall, and 10 grams of centipede (with bamboo sticks removed) are mixed and put into another traditional Chinese medicine soaking bag for later use; The two traditional Chinese medicine soaking bags are soaked in 70% ethanol. The consumption of ethanol and the specific preparation process are the same as those in Example 1 or Example 2, and will not be repeated here.

[0022] Psoriasis is a common, non-infectious erythematous, scaly skin disease of unknown cause. The traditional Chinese medical science " Bai Feng ", " Feng Feng " are equivalent to this disease. Traditional Chinese medicine believes that this disease is mostly caused by ...

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Abstract

An alkaloid salt-type medicine (psoriasis stubborn dermatitis tincture) for treating psoriasis and a preparation method thereof. The preparation method includes the steps of (1) mixing sophora flavescens and salviae miltiorrhizae and packaging the medicines in a filter bag, and packaging cortex phellodendri and glechoma hedracea in the other filter bag; (2) respectively dipping the two filter bags in 450-560 ml of ethanol for two times, sealing the ethanol and soaking the filter bags to obtain two medicine liquids; (3) mixing the two medicine liquids and blending cresol with a supernate to dissolve the cresol; (4) blending laurocapram, and adding distilled water to 1000 ml; and (5) allowing the liquid to stand and filtering the liquid to obtain the alkaloid salt-type medicine. The alkaloid salt-type medicine (psoriasis stubborn dermatitis tincture) has the effects of clearing heat and removing toxin, dispelling wind and dissipating stasis, cooling and activating blood, challenging toxin and relieving swelling, removing necrotic tissues to generate muscle. Basic tests and clinical application tests prove that the alkaloid salt-type medicine has excellent effects on the stubborn psoriasis, and is quick in effect, is short in curing period, is safe and effectively, is free of side effects and is free of relapse.

Description

technical field [0001] The invention relates to a medicine for treating psoriasis, in particular to a medicine containing an active ingredient alkaloid salt and a preparation process thereof. Background technique [0002] Psoriasis is a common chronic relapsing inflammatory skin disease. In traditional Chinese medicine, it is called Baijiao, Fengfeng, Songpi tinea and so on. The exact cause is not yet known. At present, it is believed that psoriasis is related to factors such as heredity, infection, metabolic disorder, and immune dysfunction, and its mechanism is an immune-mediated disease. The incidence rate in my country is 0.123%, and there are about 3 million people suffering from it. Various treatments for psoriasis can only achieve short-term curative effect and cannot be cured. The first is the treatment of glucocorticoid drugs, such as mometasone gluconate ointment, clofluxasone cream, super powerful betamethasone propionate, 5% to 10% salicylic acid ointment, 0....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/756A61K9/08A61P17/06A61K31/60A61K31/125A61K31/192A61K35/646A61K35/648A61K35/64
Inventor 黄冠华黄早堂
Owner 黄冠华
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