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Pulsatilla chinensis extract and application thereof to preparation of drugs for preventing and treating pulmonary fibrosis

A technology for pulmonary fibrosis and Pulsatillae, which is applied in the field of medicine, can solve the problems that Pulsatilla extracts have not been found to prevent and treat pulmonary fibrosis.

Active Publication Date: 2015-10-21
HENAN UNIV OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Pulsatilla extract has no research reports on the prevention and treatment of pulmonary fibrosis

Method used

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  • Pulsatilla chinensis extract and application thereof to preparation of drugs for preventing and treating pulmonary fibrosis
  • Pulsatilla chinensis extract and application thereof to preparation of drugs for preventing and treating pulmonary fibrosis

Examples

Experimental program
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Effect test

Embodiment 1

[0035] The Psyllium pulsatillae extract of the present invention is obtained by the following extraction methods:

[0036] a, taking Pulsatillae Radix as raw material, adding 75% ethanol (volume percentage) of 8 times of Pulsatillae weight, then placing it in a flash extractor for extraction, extracting 2 times, each extraction time is 2min; filtering each gained extract , combined the filtrates; the remaining filter residue obtained is for use; the obtained filtrate is concentrated under reduced pressure to an extract whose specific gravity is 1.05; the concentrated filtrate is extracted with petroleum ether, extracted twice, and the petroleum ether liquid is discarded after extraction, and the lower layer of water is volatilized Remove the petroleum ether, concentrate the resulting solution at 50°C to a thick paste with a relative density of 1.20, and dry under reduced pressure to obtain the crude product of Pulsatilla grandis total saponins;

[0037] b. Evaporate the remain...

Embodiment 2

[0040] The Psyllium pulsatillae extract of the present invention is obtained by the following extraction methods:

[0041] a, take Pulsatillae Radix as raw material, add 85% ethanol (volume percentage) of 10 times of Pulsatillae weight, then place in a flash extractor to extract, extract 2 times, each extraction time is 1min; filter the extracted solution obtained each time , combined the filtrates; the remaining filter residue obtained is for use; the obtained filtrate is concentrated under reduced pressure to an extract with a specific gravity of 1.10; the concentrated filtrate is extracted with petroleum ether for 2 times, and the petroleum ether liquid is discarded after extraction, and the lower layer of water is volatilized Remove petroleum ether, concentrate the resulting solution at 60°C to a thick paste with a relative density of 1.15, and dry under reduced pressure to obtain crude Pulsatilla saponins;

[0042] b. Distill the ethanol in the remaining filter residue to...

Embodiment 3

[0045] The Psyllium pulsatillae extract of the present invention is obtained by the following extraction methods:

[0046] a, taking Pulsatillae Radix as raw material, adding 50% ethanol (volume percentage) of 6 times of Pulsatillae weight, then placing it in a flash extractor for extraction, extracting 3 times, each extraction time is 1min; filtering each gained extract , combined the filtrates; the remaining filter residue obtained is for use; the obtained filtrate is concentrated under reduced pressure to an extract with a specific gravity of 1.08; the concentrated filtrate is extracted with petroleum ether, extracted twice, and the petroleum ether liquid is discarded after extraction, and the lower layer of water is volatilized Remove the petroleum ether, concentrate the resulting solution at 55°C to a thick paste with a relative density of 1.30, and dry under reduced pressure to obtain the crude product of Pulsatilla grandis total saponins;

[0047] b. Distill the ethanol...

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Abstract

The invention discloses a pulsatilla chinensis extract and application thereof to the preparation of drugs for preventing and treating pulmonary fibrosis. The pulsatilla chinensis extract uses pulsatilla chinensis as a raw material and is prepared through the following steps: firstly, adding ethanol for extraction, concentrating the obtained extracting solution until an extractum is obtained, and then extracting, concentrating and drying the extractum sequentially to obtain pulsatilla chinensis total saponins; adding distilled water into the residue after extraction, decocting and extracting, concentrating the extracting solution until an extractum is obtained, and then treating the extractum to obtain pulsatilla chinensis polysaccharide; mixing the pulsatilla chinensis total saponins with the pulsatilla chinensis polysaccharide uniformly to obtain the final pulsatilla chinensis extract. Through experimental verification, the pulsatilla chinensis extract can prevent the formation and development of pulmonary fibrosis by inhibiting the proliferation of lung fibroblast and the transformation of alveolar epithelial cells to mesenchymal cells, so that the pulsatilla chinensis extract achieves new application to the preparation of drugs for preventing and treating pulmonary fibrosis.

Description

1. Technical field: [0001] The invention relates to the technical field of medicine, in particular to a Pulsatilla pulsatilla extract and its application in the preparation of medicines for preventing and treating pulmonary fibrosis. 2. Background technology: [0002] Pulmonary fibrosis is a malignant disease that seriously threatens human health and life. The current drugs for the treatment of pulmonary fibrosis mainly include glucocorticoids, immunosuppressants and cytotoxic drugs. A small number of patients treated with glucocorticoids showed certain curative effect, but there were no complete or sustained remissions, serious side effects, uncertain long-term efficacy and other problems restricted the long-term application of these drugs. Improving the efficacy of drugs has always been the goal pursued by the majority of medical workers. With the deepening of research on the pathogenesis of pulmonary fibrosis, it has been confirmed that the excessive accumulation of col...

Claims

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Application Information

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IPC IPC(8): A61K36/71A61P11/00
Inventor 冯素香李建生刘富岗王蒙蒙罗珊
Owner HENAN UNIV OF CHINESE MEDICINE
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