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Medicine for treating chronic urticaria

A technology for chronic urticaria and medicine, applied in the field of pharmaceutical preparations with undetermined structure, can solve the problems of easy recurrence, high recurrence rate, incurable and the like

Active Publication Date: 2015-11-25
遵义医科大学珠海校区
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The course of chronic urticaria is lingering, difficult to cure and easy to relapse, bringing great pain to the patient
The commonly used western medicines in clinical practice are H1 receptor antagonist preparations such as levocetirizine and loratadine. The characteristics of their effects are symptomatic treatment, improvement after medication, reduced curative effect after long-term use, and high recurrence rate after drug withdrawal.
The commonly used traditional Chinese medicine for the treatment of chronic urticaria at present is Zixin Urticaria Pill (Z22020198), which is composed of Clematis, Radix Scutellariae, Flaxseed, Safflower, Moss bark, Smilax, Schizonepeta, Cimicifuga, Made from three needles, Tribulus terrestris, Chuanxiong, Fangfeng, Angelica, Polygonum multiflorum, Sophora flavescens, Angelica dahurica, Peppermint, Chishao and chrysanthemum, it can clear away heat and wind, dehumidify and relieve itching, and has a certain therapeutic effect on the itching symptoms of chronic urticaria. However, its effect in treating chronic urticaria is poor, and it is easy to relapse.

Method used

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  • Medicine for treating chronic urticaria
  • Medicine for treating chronic urticaria

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Embodiment 1 (granule):

[0036] Prescription: Astragalus 242g, Atractylodes macrocephala 135g, Poria cocos 361g, black snake 181g, centipede 61g, scorpion 45g, wood beetle 45g, habitat 151g, ephedra 151g, scrophulariaceae 151g, raw gypsum 151g, forged keel 481g, flavescens 151g, kochia 151g of seeds, 151g of white fresh skin, 151g of salvia miltiorrhiza, and 241g of rhizome of Imperatae.

[0037] Preparation method: Take forging keel and raw gypsum and boil for 1 hour, add the remaining 15 herbs and boil for 3 times, the first time is 0.5 hour, the second time and the third time are 2 hours each, filter, combine the filtrate, concentrate to an appropriate amount; add An appropriate amount of ethanol is precipitated, and the supernatant is collected under reduced pressure to recover ethanol until there is no alcohol smell, concentrated into a clear paste with a relative density of 1.30, dried in an oven at 65°C to form a dry paste and crushed into fine powder; the obtai...

Embodiment 2

[0038] Embodiment 2 (granule):

[0039] Prescription: Astragalus 270, Atractylodes macrocephala 143, Poria cocos 360, black snake 165, centipede 44, scorpion 38, wood beetle 45, habitat 150, ephedra 165, scrophulariaceae 180, raw gypsum 165, forging keel 480, flavescens 135, Kochia 120 seeds, 135 white fresh skin, 150 salvia miltiorrhiza, 255 rhizomes.

[0040]Preparation method: Take forging keel and raw gypsum and boil for 1 hour, add the remaining 15 herbs and boil for 3 times, the first time is 0.5 hour, the second time and the third time are 2 hours each, filter, combine the filtrate, concentrate to an appropriate amount; add An appropriate amount of ethanol is precipitated, and the supernatant is collected under reduced pressure to recover ethanol until there is no alcohol smell, concentrated into a clear paste with a relative density of 1.30, dried in an oven at 65°C to form a dry paste and crushed into fine powder; the obtained dry paste fine powder Add appropriate am...

Embodiment 3

[0041] Embodiment 3 (granule):

[0042] Prescription: Astragalus 210, Atractylodes macrocephala 127, Poria cocos 358, black snake 194, centipede 89, scorpion 53, wood beetle 45, habitat 134, ephedra 120, scrophulariaceae 134, raw gypsum 149, forging keel 492, flavescens 179, Kochia scoparia Zi 179, Bai Xian Pi 164, Salvia 149, Imperata 224.

[0043] Preparation method: Take forging keel and raw gypsum and boil for 1 hour, add the remaining 15 herbs and boil for 3 times, the first time is 0.5 hour, the second time and the third time are 2 hours each, filter, combine the filtrate, concentrate to an appropriate amount; add An appropriate amount of ethanol is precipitated, and the supernatant is collected under reduced pressure to recover ethanol until it has no alcohol smell, and is concentrated into a clear paste with a relative density of 1.30, which is dried in an oven at 65°C to form a dry paste and crushed into fine powder; the obtained dry paste is finely Add appropriate a...

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Abstract

The invention discloses a medicine for treating chronic urticaria. The medicine is composed of active ingredients and auxiliary components acceptable in medicine, wherein the active ingredients are prepared from the following raw medicinal materials in percentage by weight: 7%-9% of astragalus membranaceus, 4%-5% of white atractylodes rhizome, 11%-13% of poria cocos, 5%-7% of zaocys dhumnade, 1%-3% of centipede, 1%-2% of scorpio, 1%-2% of ground beeltle, 4%-6% of dried rehamnnia root, 4%-6% of ephedra, 4%-6% of radix scrophulariae, 4%-6% of gypsum, 15%-17% of calcined keel, 4%-6% of radix sophorae flavescentis, 4%-6% of fructus kochiae, 4%-6% of the root bark of shaggy-fruited dittany, 4%-6% of the root of red-rooted salvia, and 7%-9% of lalang grass rhizome. The medicine can be in oral preparations such as granules, capsules or tablets, and through clinical verification, the medicine has the advantages of being rapid in improving the symptoms and low in recurrence rate.

Description

technical field [0001] The invention relates to medical preparations, in particular to pharmaceutical preparations containing undetermined structures from traditional Chinese medicine raw materials. Background technique [0002] The course of chronic urticaria is lingering, difficult to cure and easy to relapse, which brings great misery to the patient. Western medicine commonly used clinically is H1 receptor antagonist preparation such as acid levocetirizine, loratadine etc., and its action characteristic is, symptomatic treatment, takes a turn for the better after taking medicine, takes curative effect for a long time and reduces, and relapse rate is high after drug withdrawal. The commonly used traditional Chinese medicine for the treatment of chronic urticaria at present is Zixin Urticaria Pill (Z22020198), which is composed of Clematis, Radix Scutellariae, Flaxseed, Safflower, Moss bark, Smilax, Schizonepeta, Cimicifuga, Made from three needles, Tribulus terrestris, Ch...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61P17/00A61K33/06A61K35/02A61K35/583A61K35/646A61K35/64A61K35/648
Inventor 莫镇涛
Owner 遵义医科大学珠海校区
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