Detection method of volatile component of xuefu zhuyu preparation

A technology of volatile components and blood stasis, applied in the field of column chromatography, can solve problems such as detection and analysis of non-volatile components, and achieve the effect of ensuring safety and effectiveness, good separation effect, and wide application prospects

Active Publication Date: 2015-12-23
TIANJIN HONGRENTANG PHARM CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The multi-flavored medicinal materials in Xuefu Zhuyu Fang contain volatile components, such as Bupleurum, Angelica, Radix Paeoniae Rubra and Chuanxiong, etc., but the 2010 edition of Pharmacopoeia of the People's Republic of China and related studies did not detect and analyze the volatile components

Method used

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  • Detection method of volatile component of xuefu zhuyu preparation
  • Detection method of volatile component of xuefu zhuyu preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1: Analysis of Volatile Components in Xuefu Zhuyu Capsules

[0017] 1. Preparation of the test article

[0018] Xuefu Zhuyu Capsules (Tianjin Hongrentang Pharmaceutical Co., Ltd., 12 capsules × 2 plates / box, 0.4g / capsule, production batch number: E03066), remove the capsule shell, take 3g of the sample powder, weigh it accurately, and place it in the headspace In the sample bottle, spare.

[0019] 2. Analysis of headspace-gas chromatography-mass spectrometry

[0020] Headspace conditions: headspace equilibration time: 30min; injection needle temperature 90°C; headspace shaking chamber heating temperature: 95°C.

[0021] Chromatographic conditions: 456GC gas chromatograph (Bruker, USA), chromatographic column VF-5ms (30m×0.25mm×0.25μm, Agilent, USA); temperature program: initial temperature 40°C, keep for 3min, with a heating rate of 10°C / min Rise to 280°C and keep for 8min; interface temperature: 280°C; carrier gas: He (purity >99.999%); flow rate: 1mL / min; s...

Embodiment 2

[0028] Example 2: Analysis of Volatile Components in Xuefu Zhuyu Tablets

[0029] 1. Preparation of the test article

[0030] Xuefu Zhuyu Tablets (Shaanxi Haitian Pharmaceutical Co., Ltd., 4×12 tablets / plate / box, 0.42g / tablet, production batch number: 140903), take Xuefu Zhuyu Tablets, pulverize, take 3g of sample powder, and accurately weigh, Place in a headspace vial for later use. Label: SXHT.

[0031] Xuefu Zhuyu Tablets (Chongqing Xi'an Pharmaceutical Co., Ltd., 3×12 tablets / plate / box, 0.45g / tablet, production batch number: 150103), take Xuefu Zhuyu Tablets, crush them, take the sample powder 3g, and accurately Weigh it, place it in a headspace vial, and set aside. Label: CQXEA.

[0032] 2. Analysis of headspace-gas chromatography-mass spectrometry

[0033] Headspace conditions: headspace equilibration time: 30min; injection needle temperature: 90°C; headspace shaking chamber heating temperature: 95°C.

[0034] Chromatographic conditions: 456GC gas chromatograph (Br...

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Abstract

The invention discloses a detection method of volatile components of a xuefu zhuyu preparation and belongs to the field of column chromatography. The detection method adopts a headspace-gas chromatography-mass spectrometer to analyze volatile components in vessel stasis removing capsules and vessel stasis removing tablets. The detection method specifically comprises the following steps: (1) preparing test products; (2) optimizing analysis conditions of the volatile components of the vessel stasis removing preparation and performing sample detection; (3) analyzing data, searching an NISI-10 standard mass spectra library to obtain the volatile components in the vessel stasis removing capsules and tablets, and calculating the relative percentage content of each component. The detection method of the volatile components of the vessel stasis removing preparation fills a blank in the field of methods for detecting volatile substances in vessel stasis removing samples in the prior art, is simple, sensitive and quick, provides a basis for researches on the volatile components of the xuefu zhuyu preparation, and has a wide application value.

Description

technical field [0001] The invention belongs to the field of column chromatography, in particular to a method for detecting volatile components of Xuefu Zhuyu preparation. Background technique [0002] Xuefu Zhuyu Prescription originated from "Yilin Gaicuo" written by Wang Qingren, a physician in the Qing Dynasty. It is a classic prescription among the prescriptions for promoting blood circulation and removing blood stasis. The prescription is composed of eleven traditional Chinese medicines of Bupleurum, Angelica, Rehmannia, Radix Paeoniae Rubra, Safflower, Stir-fried Peach Kernel, Stir-fried Fructus Aurantii, Licorice, Chuanxiong, Achyranthes bidentata and Platycodon grandiflorum. Over time, the pain is like a pinprick and has a fixed location, internal heat and depression, palpitations, insomnia, irritability, etc. Based on the Xuefu Zhuyu formula, Xuefu Zhuyu capsules and tablets have been researched and developed by modern pharmaceutical technology. The multi-flavor m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/02
Inventor 朱晓晶王跃飞杨欣莹于卉娟江振作杨帆
Owner TIANJIN HONGRENTANG PHARM CO LTD
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