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Compound anti-cold medicine composition and use thereof

A technology of composition and cold medicine, which is applied in the field of medicine, can solve the problems of small dosage, frequent adverse reactions, exaggerated advertisements, etc., and achieve the effect of reducing the dosage and reducing the occurrence of toxic adverse reactions

Active Publication Date: 2018-10-30
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there are many types of medicines in the cold medicine market, but the advertisements are exaggerated. Secondly, the frequent occurrence of adverse reactions is the primary problem we face, and the way to avoid adverse reactions of medicines should be to choose low toxic side effects and small doses as the new research and development direction.

Method used

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  • Compound anti-cold medicine composition and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] experimental method:

[0023] 30 KM mice were taken and adaptively fed for 3 days in a laboratory environment (breeding environment: temperature 18-25° C.). Randomly divided into 3 groups, 10 in each group. Numbered after weighing. Group 1 was a blank control group, Group 2 was given compound cold medicine composition prescription 1 (30 mg ibuprofen, 30 mg fexofenadine, 30 mg benproperine), and Group 3 was given 60 mg / kg benproperine phosphate. The mice were fasted 8 h before the experiment, and had free access to water. According to the dose of 0.1ml / 10g, it is administered by intragastric administration, and the operation is completed within 2 minutes. After 30 minutes of administration, the ammonia water induced cough test was carried out. Draw 0.3ml of ammonia water, inject it into a cotton ball, buckle the cotton ball together with the mouse in the beaker for 150s, observe and record the cough frequency and cough latency of the mouse. Cough is manifested as: m...

Embodiment 2

[0030] experimental method:

[0031] 30 KM mice were taken and adaptively fed for 3 days in a laboratory environment (breeding environment: temperature 18-25° C.). Randomly divided into 3 groups, 10 in each group. Numbered after weighing. Group 1 was a blank control group, Group 2 was given compound cold medicine composition prescription 1 (30 mg of ibuprofen, 30 mg of fexofenadine, 60 mg of benproperine), and Group 3 was given 30 mg / kg of ibuprofen. All the drugs were given by intragastric administration, and the croton oil inflammatory agent was applied to both sides of the right ears of the mice in each group 0.5 h after the administration. After 2 hours of administration, the mice were killed by dislocation of the neck, and the left and right ears were cut off with a 0.7 mm punch, and weighed. Taking the swelling value [(right ear weight-left ear weight) / left ear weight×100%] as an index, the t test was used to calculate the data between groups to evaluate the drug effe...

Embodiment 3

[0038] experimental method:

[0039] Eighteen guinea pigs were taken and adaptively fed for 3 days in a laboratory environment (breeding environment: temperature 18-25° C.). Randomly divided into 3 groups, 6 in each group. After dissolving citric acid into normal saline to make a concentration of 0.1M, these guinea pigs were exposed to the nebulized citric acid environment for 10 minutes, and the number of coughs during the 10 minutes of exposure to this environment was counted, and the number of coughs was calculated according to the number of coughs. How many weighing group numbers. Group 1 was a blank control group, group 2 was given compound cold medicine composition prescription 1 (1 mg ibuprofen, 2 mg fexofenadine, 1 mg benproperine), and group 3 was given 2 mg / kg fexofenadine. On the next day after the stimulation with citric acid, the drugs were given by intragastric administration, and 6uM ATP aerosol was inhaled 1 hour after the administration. The aerosol was gen...

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Abstract

The invention relates to a compound anti-cold medicine combination. The combination is composed of ibuprofen in physiologically effective dosage as well as pharmaceutically acceptable salt thereof, fexofenadine as well as pharmaceutically acceptable salt thereof and benproperine and pharmaceutically acceptable salt thereof serving as main medicinal active ingredients and pharmaceutically acceptable supplementary materials. Due to combining of the above three compounds, the combination has the advantages of little side effect, quick action and good synergistic effect and is mainly used for treating symptoms in the middle and late stages of cold.

Description

technical field [0001] The invention relates to the field of medicine, in particular to a compound anti-cold medicinal composition and its application. Background technique [0002] In the whole world, cold is a relatively common disease, and anti-cold medicine has naturally become one of the most frequently used and largest used medicines. The composition of anti-cold medicine components can generally be divided into the following types, antipyretic and analgesic components, antitussive components, and antihistamines. [0003] Cold medicines containing antihistamines, such as chlorpheniramine and diphenhydramine, have side effects of causing drowsiness. Drivers, workers at heights, and fine-work operators should not take them, at least not during the day. [0004] Cold medicines containing antipyretic and analgesic ingredients, such as diclofenac, should not be used by patients with gastric and duodenal ulcers, liver and kidney insufficiency, pregnant women, and children; ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/4453A61P29/00A61P11/06A61P37/08A61K31/192A61K31/445
Inventor 刘铮阚启明赵剑孙铁民何仲贵
Owner SHENYANG PHARMA UNIVERSITY
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