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Compound anti-cold medicine composition and application thereof

A composition and technology of cold medicine, applied in the field of medicine, can solve problems such as frequent adverse reactions, low toxic and side effects, and exaggerated advertisements, and achieve the effects of increasing the secretion of serous glands in the respiratory mucosa, promoting secretion, and reducing fever for a long time

Inactive Publication Date: 2015-08-05
SHENYANG PHARMA UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, there are many types of medicines in the cold medicine market, but the advertisements are exaggerated. Secondly, the frequent occurrence of adverse reactions is the primary problem we face, and the way to avoid adverse reactions of medicines should be to choose low toxic side effects and small doses as the new research and development direction.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] experimental method:

[0022] 30 KM mice were taken and adaptively fed for 3 days in a laboratory environment (breeding environment: temperature 18-25° C.). Randomly divided into 3 groups, 10 in each group. Numbered after weighing. Group 1 is a blank control group, group 2 is given compound cold medicine composition prescription (30mg of ibuprofen, 30mg of fexofenadine, 30mg of benproperine, 30mg of ambroxol), and group 3 is given of benproperine 60mg / kg. The mice were fasted 8 h before the experiment, and had free access to water. According to the dose of 0.1ml / 10g, it is administered by intragastric administration, and the operation is completed within 2 minutes. After 30 minutes of administration, the ammonia water induced cough test was carried out. Draw 0.3ml of ammonia water, inject it into a cotton ball, buckle the cotton ball together with the mouse in the beaker for 150s, observe and record the cough frequency and cough latency of the mouse. Cough is man...

Embodiment 2

[0029] experimental method:

[0030] 30 KM mice were taken and adaptively fed for 3 days in a laboratory environment (breeding environment: temperature 18-25° C.). Randomly divided into 3 groups, 10 in each group. Numbered after weighing. Group 1 was a blank control group, group 2 was given compound cold medicine composition prescription (30 mg ibuprofen, 30 mg fexofenadine, 30 mg benproperine, 30 mg ambroxol), group 3 was given 30 mg / kg ibuprofen . All the drugs were given by intragastric administration, and the croton oil inflammatory agent was applied to both sides of the right ears of the mice in each group 0.5 h after the administration. After 2 hours of administration, the mice were killed by dislocation of the neck, and the left and right ears were cut off with a 0.7 mm punch, and weighed. Taking the swelling value [(right ear weight-left ear weight) / left ear weight×100%] as an index, the t test was used to calculate the data between groups to evaluate the drug effe...

Embodiment 3

[0037] experimental method:

[0038] Eighteen guinea pigs were taken and adaptively fed for 3 days in a laboratory environment (breeding environment: temperature 18-25° C.). Randomly divided into 3 groups, 6 in each group. After dissolving citric acid into normal saline to make a concentration of 0.1M, these guinea pigs were exposed to the nebulized citric acid environment for 10 minutes, and the number of coughs during the 10 minutes of exposure to this environment was counted, and the number of coughs was calculated according to the number of coughs. How many weighing group numbers. Group 1 was a blank control group, group 2 was given compound cold medicine composition prescription (30 mg ibuprofen, 30 mg fexofenadine, 30 mg benproperine, 30 mg ambroxol), group 3 was given 2 mg fexofenadine / kg. On the next day after the stimulation with citric acid, the drugs were given by intragastric administration, and 6uM ATP aerosol was inhaled 1 hour after the administration. The ...

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Abstract

The invention relates to the field of medicines, in particular to a compound anti-cold medicine composition and application thereof. The compound anti-cold medicine composition consists of a physiologically effective dose of ibuprofen and pharmaceutically acceptable salt thereof, fexofenadine and pharmaceutically acceptable salt thereof, benproperine and pharmaceutically acceptable salt thereof, and ambroxol and pharmaceutically acceptable salt thereof, of which the weight ratio is 1: (1-2): (0.5-1): (0.5-1). According to the compound anti-cold medicine composition and application thereof, as the four medicines are combined for use, the function of the compound anti-cold medicine composition is stronger than a folk prescription of the same dose in some aspect, accordingly, the synergistic effect of medicines is given into full play, the using dose of the medicines is reduced, and the probability of toxic or adverse effects is reduced.

Description

technical field [0001] The invention relates to the field of medicine, and relates to a compound anti-cold medicine composition and use thereof, in particular to a composition composed of ibuprofen, fexofenadine, benproperine and ambroxol and use thereof. Background technique [0002] In the whole world, cold is a relatively common disease, and anti-cold medicine has naturally become one of the most frequently used and largest used medicines. The composition of anti-cold medicine components can generally be divided into the following types, antipyretic and analgesic components, antitussive components, antihistamines and expectorants. [0003] Cold medicines containing antihistamines, such as chlorpheniramine and diphenhydramine, have side effects of causing drowsiness. Drivers, workers at heights, and fine-work operators should not take them, at least not during the day. [0004] Cold medicines containing antipyretic and analgesic ingredients, such as diclofenac, should not...

Claims

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Application Information

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IPC IPC(8): A61K31/4453A61P11/14A61P29/00A61P37/08A61P11/12A61P11/10A61K31/445A61K31/192A61K31/137
Inventor 叶皓刘铮张辉李瑞芸赵剑阚启明
Owner SHENYANG PHARMA UNIVERSITY
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