Application of ginsenoside Rg1 to preparation of medicines for prevention and/or treatment of myocardial ischemia

A technology of ginsenoside and myocardial ischemia, which is applied in drug combination, cardiovascular system diseases, and pharmaceutical formulations, etc.

Inactive Publication Date: 2016-02-10
TIANJIN TASLY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no evidence of in vivo experiments to explore the improvement effect of ginsenoside Rg1 on myocardial ischemia-reperfusion injury in rats from the perspective of energy metabolism, inhibition of inflammation and apoptosis

Method used

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  • Application of ginsenoside Rg1 to preparation of medicines for prevention and/or treatment of myocardial ischemia
  • Application of ginsenoside Rg1 to preparation of medicines for prevention and/or treatment of myocardial ischemia
  • Application of ginsenoside Rg1 to preparation of medicines for prevention and/or treatment of myocardial ischemia

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0519] tablet

[0520] 【prescription】

[0521] Ginsenoside Rg1100g

[0522] Microcrystalline cellulose 50g

[0523] Micropowder silica gel 3g

[0524] Magnesium stearate 1.5g

[0525] [Preparation method] Take the raw materials and auxiliary materials and pass them through a 100-mesh sieve; take ginsenoside Rg1 and microcrystalline cellulose, mix them evenly, use 60% ethanol in an appropriate amount as a binder to make a soft material, pass through a 20-mesh sieve to make granules, and dry at 60°C , take it out, sieve through a 30-mesh sieve for granulation, add micropowder silica gel and magnesium stearate, mix well, press into tablets, and make 1,000 tablets, to obtain.

Embodiment 2

[0527] 【prescription】

[0528] Ginsenoside Rg175g

[0529] Microcrystalline cellulose 37g

[0530] Micropowder silica gel 2.3g

[0531] Magnesium stearate 1.1g

[0532] [Preparation method] Take the raw materials and auxiliary materials and pass them through a 100-mesh sieve; take ginsenoside Rg1 and microcrystalline cellulose, mix them evenly, use 60% ethanol in an appropriate amount as a binder to make a soft material, pass through a 20-mesh sieve to make granules, and dry at 60°C , take it out, sieve through a 30-mesh sieve for granulation, add appropriate amount of micropowder silica gel and magnesium stearate, mix well, press into tablets, and make 1000 tablets, to obtain.

Embodiment 3

[0534] 【prescription】

[0535] Ginsenoside Rg1133g

[0536] Microcrystalline cellulose 66g

[0537] Micropowder silica gel 4g

[0538] Magnesium stearate 2g

[0539] [Preparation method] Take raw materials and auxiliary materials and pass through 100-mesh sieve respectively; take ginsenoside Rg11 and microcrystalline cellulose, mix well, use 60% ethanol as an appropriate amount of binder to make soft material, pass through 20-mesh sieve to make granules, and dry at 60°C , take it out, sieve through a 30-mesh sieve for granulation, add appropriate amount of micropowder silica gel and magnesium stearate, mix well, press into tablets, and make 1000 tablets, to obtain.

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PUM

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Abstract

The invention relates to application of ginsenoside Rg1 to preparation of medicines for prevention and / or treatment of myocardial ischemia. The ginsenoside Rg1 is capable of improving myocardial energy metabolism and cardiac functions, reducing myocardial infarction area and increasing cardiac surface blood flow volume to realize treatment and prevention of myocardial ischemia.

Description

Technical field: [0001] The invention relates to the application of a medicine, in particular to the research on the improvement effect of ginsenoside Rg1 on myocardial ischemia. Background technique: [0002] Coronary heart disease has ranked among the top three in the mortality rate in China and major developed countries abroad, and its incidence rate is showing an increasing trend year by year [1] . Acute myocardial infarction (AMI) remains the leading cause of death and disability worldwide. After acute myocardial infarction, percutaneous coronary intervention (PCI) has become the most commonly used clinical treatment. Although PCI can restore cardiac perfusion, it cannot reduce the mortality rate of patients with stable angina pectoris. [2] , Reperfusion itself can lead to the process of myocardial cell death, called myocardial reperfusion injury (ischemia / reperfusion, I / R), PCI-induced ischemia-reperfusion injury is the main pathological basis of cardiac events in pa...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/704A61P9/10
Inventor 韩晶岩李琳阎丽崔元辰刘育英潘春水贺珂
Owner TIANJIN TASLY PHARMA CO LTD
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