A kind of tafluprost eye drop and preparation method thereof
A technology of tafluprost and eye drops, which is applied in the field of medicine, can solve the problems of tafluprost in water solubility, poor stability, and low solubility, and achieve the effects of improving curative effect, reasonable preparation process, and reducing impurities
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Embodiment 1
[0028] prescription:
[0029]
[0030] Preparation Process:
[0031] Weigh polyethylene glycol-15-hydroxystearate and dissolve it in water for injection, add tafluprost, stir to dissolve; take glycerin, EDTA-2Na, benzalkonium chloride, and disodium hydrogen phosphate and dissolve in boiling water In the water for injection, stir to dissolve; after cooling to room temperature, combine the two liquids, filter, dilute with water for injection to prepare the full amount, adjust the pH to 6.0, filter through a 0.22μm microporous filter membrane, and aseptically fill in plastic eye drops Get it in a water bottle.
Embodiment 2
[0033] prescription:
[0034]
[0035]
[0036] Preparation Process:
[0037] Weigh polyethylene glycol-15-hydroxystearate and dissolve it in water for injection, add tafluprost, stir to dissolve; take sodium chloride, EDTA-2Na, benzalkonium chloride, disodium hydrogen phosphate and dissolve in In boiling water for injection, stir to dissolve; after cooling to room temperature, combine the two liquids, filter, dilute with water for injection to prepare the full volume, adjust the pH to 6.0, filter through 0.22μm microporous membrane, sterile filling in plastic Get it in eye drops bottle.
Embodiment 3
[0039] prescription:
[0040]
[0041] Preparation Process:
[0042] Weigh polyethylene glycol-15-hydroxystearate and dissolve it in water for injection, add tafluprost, stir to dissolve; take glycerin, EDTA-2Na, ethyl p-hydroxybenzoate, and disodium hydrogen phosphate and dissolve in In boiling water for injection, stir to dissolve; after cooling to room temperature, combine the two liquids, filter, dilute with water for injection to prepare the full volume, adjust the pH to 6.0, filter through 0.22μm microporous membrane, sterile filling in plastic Get it in eye drops bottle.
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