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Application of Astataricusones A in preparation of antibacterial drugs

An anti-bacterial and drug technology, applied in anti-bacterial drugs, resistance to vector-borne diseases, pharmaceutical formulations, etc., can solve problems such as irritation, dizziness, allergies, antibacterial drug accumulation and strong toxicity

Inactive Publication Date: 2016-03-16
ZIBO DINGLI PATENT INFORMATION CONSULTING CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Antibacterial drugs have been widely used in the treatment of AIDS, organ transplantation and chronic wasting diseases (such as cancer, diabetes, uremia, etc.) , but these antibacterial drugs have strong cumulative toxicity, often causing liver and kidney damage, gastrointestinal irritation, dizziness, allergies, etc., so looking for new antibacterial drugs with unique mechanism of action has become one of the hot spots in drug research and development today

Method used

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  • Application of Astataricusones A in preparation of antibacterial drugs
  • Application of Astataricusones A in preparation of antibacterial drugs
  • Application of Astataricusones A in preparation of antibacterial drugs

Examples

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Effect test

Embodiment 1

[0013] Embodiment 1: the preparation of compound AstataricusonesA tablet involved in the present invention:

[0014] Take 5 grams of compound Astataricusones A, add 195 grams of dextrin, mix well, and make 1000 tablets by conventional compression.

Embodiment 2

[0015] Embodiment 2: the preparation of compound AstataricusonesA capsules involved in the present invention:

[0016] Get 5 grams of compound Astataricusones A, add 195 grams of starch, mix evenly, and make 1000 capsules.

[0017] The following pharmacodynamic experiments will further illustrate its drug activity.

experiment example 1

[0018] Experimental Example 1: Experimental Research on the Antibacterial Activity of Astataricusones A

[0019] The antibacterial activity experiment is the method of concentration dilution, and each measurement is repeated three times. The test pathogens include Escherichia coli, Pseudomonas fluorescens, Staphylococcus aureus, Proteus, and Cryptococcus neoformans, and the concentration of the bacteria solution is 10 5 individual / mL. The initial concentration of Astataricusones A is 50.0 μg / mL (5% dimethyl sulfoxide DMSO), serially diluted to 0.098 μg / mL, and equal volumes of bacterial liquid and test samples are mixed and cultured in a 96-well plate, and the bacterial culture temperature is respectively 37°C, observe after 24 hours of incubation, if no colonies are found, it is the lowest antibacterial concentration of the sample, that is, the MIC value. The positive control of this experiment is amikacin sulfate, and the antibacterial results of Astataricusones A are shown...

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Abstract

The invention relates to application of Astataricusones A in preparation of antibacterial drugs. Astataricusones A has strong inhibitory effect on escherichia coli, pseudomonas fluorescens, Staphylococcus aurous, proteus species and cryptococcus neoformans, can serve as an antibacterial compound, and the features are disclosed for the first time. Also due to strong bacteriostatic activity, Astataricusones A has outstanding substantive characteristics, and at the same time has remarkable progress in prevention and treatment of bacterial infection.

Description

technical field [0001] The present invention relates to the new application of compound Astataricusones A, in particular to the application of Astataricusones A in the preparation of antibacterial drugs. Background technique [0002] Antibacterial drugs have been widely used in the treatment of AIDS, organ transplantation and chronic wasting diseases (such as cancer, diabetes, uremia, etc.) , but these antibacterial drugs have strong cumulative toxicity, often causing liver and kidney damage, gastrointestinal irritation, dizziness, allergies, etc., so looking for new antibacterial drugs with unique mechanism of action has become one of the hot spots in drug research and development today. [0003] The compound AstataricusonesA involved in the present invention is a new compound published in 2013 (Wen-BingZhou, et al., AstataricusonesA–DandAstataricusolA, FiveNewAnti-HBVShionane-TypeTriterpenesfromAstertataricusL.f..Molecules2013,18,14585-14596.), the compound has a new Skel...

Claims

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Application Information

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IPC IPC(8): A61K31/56A61P31/04
CPCA61K9/2059A61K9/4866A61K31/56Y02A50/30
Inventor 田丽华
Owner ZIBO DINGLI PATENT INFORMATION CONSULTING CO LTD
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