The preparation method of high-purity granular amprolium hydrochloride

A kind of technology of amprolium hydrochloride and amprolium hydrochloride crude product, applied in the field of preparation of high-purity amprolium hydrochloride granular type, can solve the problems of unsolved uniformity problem, difficulty in mixing other raw materials, poor solubility and the like , to achieve the effect of not easy to agglomerate and agglomerate, good fluidity and good solubility

Active Publication Date: 2018-01-19
ZHEJIANG DAYANG BIOTECH GROUP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0016] The amprolium hydrochloride micropowder produced by the conventional process (the process of refining with methanol as a solvent) is easy to agglomerate, has poor fluidity and poor solubility, and it is difficult to mix with other raw materials, and the problem of uniformity cannot be solved. , There is also a lot of dust during the operation

Method used

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  • The preparation method of high-purity granular amprolium hydrochloride
  • The preparation method of high-purity granular amprolium hydrochloride
  • The preparation method of high-purity granular amprolium hydrochloride

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0055] Embodiment 1, a kind of preparation method of high-purity amprolium hydrochloride granule, carries out following steps successively:

[0056] 1) At room temperature, add 150 liters of pure water (i.e., deionized water) to a 1000-liter dissolving and decolorizing kettle, start stirring, weigh 150 kg of crude amprolium hydrochloride, and put it into the dissolving and decolorizing kettle until it is completely dissolved , to get 300 kilograms of amprolium hydrochloride solution I;

[0057] The amprolium hydrochloride crude product is the condensation reaction product of 4-amino-(5-methoxymethyl)-2-propylpyrimidine and 2-picoline under the hydrogen chloride system, and its quality index is as follows: amprolium hydrochloride The content (on a dry basis) is 95.2%, the related impurities are 1.92%, the residue on ignition is 1.67%, the loss on drying is 8.8%, and the appearance is khaki.

[0058] 2), open steam valve, step 1) gained 300 kilograms of amprolium hydrochloride ...

Embodiment 2

[0070] Embodiment 2, a kind of preparation method of high-purity amprolium hydrochloride granule, comprises the following steps successively:

[0071] 1), at room temperature, add 250 liters of pure water to a 1000 liter dissolving and decolorizing kettle, start stirring, weigh 150 kilograms of crude product of amprolium hydrochloride, put it into the dissolving and decolorizing kettle until it is completely dissolved, and obtain 400 kilograms of amprolium hydrochloride Phenyl solution Ⅰ;

[0072] The amprolium hydrochloride crude product is the condensation reaction product of 4-amino-(5-methoxymethyl)-2-propylpyrimidine and 2-picoline under the hydrogen chloride system, and its quality index is as follows: amprolium hydrochloride The content (on a dry basis) is 95.2%, the related impurities are 1.92%, the residue on ignition is 1.67%, the loss on drying is 8.8%, and the appearance is khaki.

[0073] 2), open steam valve, step 1) gained 400 kilograms of amprolium hydrochlori...

Embodiment 3

[0084] Embodiment 3, a kind of preparation method of high-purity amprolium hydrochloride granule, comprises the following steps successively:

[0085] 1) At room temperature, add 150 liters of pure water to a 1000-liter dissolving and decolorizing kettle, start stirring, weigh 150 kilograms of crude product of amprolium hydrochloride, and put it into the dissolving and decolorizing kettle until it is completely dissolved to obtain 300 kilograms of amprolium hydrochloride Phenyl solution Ⅰ;

[0086] The amprolium hydrochloride crude product is the condensation reaction product of 4-amino-(5-methoxymethyl)-2-propylpyrimidine and 2-picoline under the hydrogen chloride system, and its quality index is as follows: amprolium hydrochloride The content (on a dry basis) is 95.2%, the related impurities are 1.92%, the residue on ignition is 1.67%, the loss on drying is 8.8%, and the appearance is khaki.

[0087] 2), open steam valve, step 1) gained 300 kilograms of amprolium hydrochlor...

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Abstract

The invention discloses a method for preparing high-purity granular type amprolium hydrochloride. The method comprises the following steps: dissolving an amprolium hydrochloride crude product in water, and adding activated carbon to decolorize and remove impurities; adding organic solvent into the decolorized amprolium hydrochloride solution to separate amprolium hydrochloride crystal so as to respectively obtain an amprolium hydrochloride wet product I and mother liquor I; performing distillation and concentration at reduced pressure on the mother liquor I, adding organic solvent to separate crystal so as to respectively obtain an amprolium hydrochloride wet product II and a mother liquor II; mixing the amprolium hydrochloride wet product I with the amprolium hydrochloride wet product II, granulating, drying and screening to obtain the high-purity granular type amprolium hydrochloride. The high-purity granular type amprolium hydrochloride cannot be easily aggregated or caked, has good fluidity, good dissolubility and high purity, and does not have the risk that solvent residues exceed the standard.

Description

technical field [0001] The invention belongs to the field of chemical industry and medicine, and relates to the preparation technology of veterinary raw materials, in particular to a preparation method of high-purity amprolium hydrochloride in granular form. Background technique [0002] Coccidiosis is a parasitic disease that damages the intestinal tract of poultry. It is a disease that many commercial poultry farmers fear. Mortality losses of more than 20% are common. Serious losses occurred. In the 1950s, the chemically synthesized anticoccidial drug nicarbazine was used, and drug control became the most effective, convenient and commonly used method for coccidiosis. [0003] The annual consumption of coccidiostats in the world is about 320 million US dollars. With the development of the aquaculture industry and the impact of coccidiosis on the aquaculture industry, the demand for anticoccidiosis drugs will increase year by year. Amprolium hydrochloride, also known as a...

Claims

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Application Information

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Patent Type & AuthorityPatents(China)
IPC IPC(8): A61K9/16A61K31/506A61P33/02
CPCA61K9/16A61K31/506
Inventor王国平徐旭辉方中周转忠兰金林汪贤高陈荣光马建明刘畅
OwnerZHEJIANG DAYANG BIOTECH GROUP