Flexible differential array electrochemical glucose sensor and use method thereof

Abstract

A flexible differential array electrochemical glucose sensor and a use method thereof are disclosed, the sensor comprises seven sensor units which are identical in structure and arranged side by side, each sensor unit comprises a flexible substrate and a first three-electrode monomer and a second three-electrode monomer which are arranged on the flexible substrate, and the first three-electrode monomer and the second three-electrode monomer are identical in structure, and both comprise a reference electrode, an auxiliary electrode and a working electrode. The use method is as follows: one sensor unit is used in one day, seven days of continuous measurement can be achieved, and in the manner of transposition measurement, the skin sensibility phenomenon caused by long time extraction of tissue fluid can be reduced. The flexible differential array electrochemical glucose sensor has small size and high precision advantages, can achieve in-situ measurement, also can achieve the integration of glucose concentrations of transdermal extraction tissue fluid and measurement extraction tissue fluid, solves the problems of adhesion of skin and the sensor in the extraction process and the skin sensibility and the like caused by long time extraction, and eliminates the influence of environmental factors on sensor measurement results.

Description

technical field [0001] The present invention relates to a glucose sensor. In particular, it relates to an integrated flexible differential array electrochemical glucose sensor capable of realizing the transdermal extraction of interstitial fluid and measuring the glucose concentration in the extracted interstitial fluid and its use method. Background technique [0002] With the improvement of people's living standards, changes in diet structure and lifestyle, population aging and the increase in the incidence of obesity, the incidence of diabetes is increasing year by year. The importance of continuous blood glucose monitoring in the diagnosis and treatment of diabetes has been increasingly recognized by people. If painless and uninterrupted continuous blood glucose monitoring can be performed on patients and more closely data on continuous changes in blood glucose concentration can be provided, it will be able to reflect the "full picture" of the patient's blood glucose, m...

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Problems solved by technology

Although this method can also obtain the blood sugar concentration, there are many problems.

First of all, the extracted interstitial fluid exists in the form of droplets on the skin surface, which is difficult to collect. Usually, it needs to be diluted with a buffer solution, and then measured. This requires knowing the volume of the extracted interstitial fluid to be calculated. The corresponding glucose concentration increases the complexity and error of the measurement; secondly, the microfluidic chip is used to extract the tissue fluid, and the measurement needs to be completed after the liquid is transferred. During the transfer process of the liquid, some will inevitably be lost, which will cause There is a large error in the measurement result

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