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Brefeldin A combined anti-cancer compound medicine

A technology of brefeldin and feldspar, applied in the field of anti-cancer compound drugs combined with brefeldin A, can solve the problems of large economic burden for patients, immature technology, complicated preparation methods, etc., and achieve relief Economic burden, reduction of human injury, reduction of toxic and side effects

Inactive Publication Date: 2016-04-06
GUANGDONG UNIV OF TECH
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Problems solved by technology

[0004] Chinese patent 201310364101.2 discloses a combined application of isothiocyanate compounds and kinase inhibitors in the treatment of cancer. The combined application of drugs, but the kinase inhibitor anticancer drugs are still in the research stage, the technology is not mature enough, the preparation method is complicated, and the price is relatively high, which brings great economic burden to patients

Method used

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  • Brefeldin A combined anti-cancer compound medicine
  • Brefeldin A combined anti-cancer compound medicine
  • Brefeldin A combined anti-cancer compound medicine

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Embodiment 1

[0022] Docetaxel (Docetaxol (DTC)) or Brefeldin A ((+)-Brefeldin A (BFA)) or docetaxel (DTC) and Brefeldin A (BFA) alone are given below. ) were used in combination to study the growth and apoptosis of human prostate cancer cells PC-3 (androgen-independent).

[0023] In the initial research of the technical solution provided by the invention, we screened the effect of a certain number of compounds and different doses of the corresponding compounds on the human prostate cancer cell PC-3 (androgen-independent), and found that docetaxel (DCT) in its Different doses administered alone have different degrees of inhibition of growth and induction of apoptosis on prostate cancer cells PC-3 ( figure 1 ). Brefeldin A (BFA) has a strong inhibitory growth-inducing apoptosis effect on prostate cancer cell PC-3 at different doses administered alone ( figure 2 ).

[0024] In the comparative experiment of in-depth study of drug combination application, the single dose of docetaxel, the s...

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Abstract

The invention discloses a brefeldin A combined anti-cancer compound medicine, aims to provide a brefeldin A combined anti-cancer compound medicine which has low using concentration and small toxic and side effects and has an excellent treatment effect on tumors, in particular prostatic cancer, and belongs to the technical field of medicines. According to the technical key points, the medicine is prepared from brefeldin A combined with taxane drugs.

Description

technical field [0001] The invention relates to an anticancer drug, in particular to an anticancer compound drug combined with Brefeldin A, belonging to the technical field of medicine. Background technique [0002] Prostate cancer (PCa) is the second most common malignant tumor in men worldwide. In developed countries and regions such as Europe and the United States, its mortality rate ranks second among various cancers. In recent years, due to the influence of environmental pollution, westernization of dietary structure and aging population, the incidence of prostate cancer in my country has increased sharply, showing a rapid upward trend. The prevention and treatment of PCa has become an important topic in the field of cancer treatment, and has attracted the attention of many experts. One of the main treatment methods for early prostate cancer is endocrine therapy with anti-androgen, but many patients will become dependent on androgen, and the anti-androgen therapy lose...

Claims

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Application Information

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IPC IPC(8): A61K31/365A61P35/00A61K31/337
CPCA61K31/337A61K31/365A61K2300/00
Inventor 黄华容郑希杜志云张焜林卫萍吴晓凤王艳磊
Owner GUANGDONG UNIV OF TECH
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