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A pharmaceutical composition for treating rhinitis and its preparation method and quality detection method

A composition and drug technology, applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc., can solve problems such as failure to treat both symptoms and root causes, failure to cure the cause of disease, side effects, etc.

Inactive Publication Date: 2017-05-31
MUDANJIANG MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] Currently, there are drugs on the market for treating allergic chronic rhinitis. Western medicine mainly uses drugs that constrict nasal blood vessels such as ephedrine, antihistamines such as cetirizine, and steroid hormone sprays. And there are different degrees of side effects; in addition, there is traditional Chinese medicine treatment, because the side effects are small, and the effect is better for the treatment of the cause. At present, there are many types of related Chinese medicines, but because they only treat the source of the disease without symptomatic treatment, they have not achieved the effect of treating both symptoms and root causes.

Method used

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  • A pharmaceutical composition for treating rhinitis and its preparation method and quality detection method
  • A pharmaceutical composition for treating rhinitis and its preparation method and quality detection method
  • A pharmaceutical composition for treating rhinitis and its preparation method and quality detection method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0182] Prescription: cypress fruit 50g, domino grass 50g, shield fruit grass 50g, bell bell notoginseng 50g.

[0183] Preparation method: Take 50g dried cypress fruit, 50g domino grass, 50g shield fruit grass, 50g bell bell notoginseng, add 1000mL water, decoct twice, 1 hour each time, filter the decoction, combine the filtrates, add 0.01% Sodium lauryl sulfate 2mL, add water to 1000mL, mix well, make nasal drops.

[0184] Detection method:

[0185] 1. The content determination of asiaticoside was carried out by high performance liquid chromatography:

[0186] (1) Chromatographic conditions: using HypersilDs chromatographic column; mobile phase: acetonitrile-water ratio of 30:70; detection wavelength: 200nm; column temperature: 20°C; flow rate: 1.0mL min -1 ;Injection volume: 10μL;

[0187] (2) Preparation of reference substance solution: Accurately weigh an appropriate amount of asiaticoside reference substance dried at 80°C to constant weight, add methanol to dissolve to ...

Embodiment 2

[0200] Prescription: cypress fruit 33g, domino grass 66g, shield fruit grass 33g, bell bell notoginseng 66g.

[0201] Preparation method: Take 33g of dried cypress fruit, 66g of domino grass, 33g of shield fruit grass, 66g of bell bell notoginseng, add 800mL of water, decoct once for 2 hours, filter the decoction, add 0.01% sodium lauryl sulfate 2mL, add water to 1000mL, make nasal drops.

[0202] Detection method:

[0203] 1. The content determination of asiaticoside was carried out by high performance liquid chromatography:

[0204](1) Chromatographic conditions: using HypersilDs chromatographic column; mobile phase: acetonitrile-water ratio of 30:70; detection wavelength: 200nm; column temperature: 20°C; flow rate: 1.0mL min -1 ;Injection volume: 10μL;

[0205] (2) Preparation of reference substance solution: Accurately weigh an appropriate amount of asiaticoside reference substance dried at 80°C to constant weight, add methanol to dissolve to make a reference substance ...

Embodiment 3

[0218] Prescription: cypress fruit 66g, domino grass 33g, shield fruit grass 66g, bell bell notoginseng 33g.

[0219] Preparation method: Take 66g of dried cypress fruit, 33g of domino grass, 66g of shield fruit grass, and 33g of bell bell notoginseng, add 600mL of water, decoct twice for 1.5 hours each time, filter the decoction, combine the filtrates, and add 0.01% Sodium lauryl sulfate 2mL, add water to 1000mL, mix well, make nasal drops.

[0220] Detection method:

[0221] 1. The content determination of asiaticoside was carried out by high performance liquid chromatography:

[0222] (1) Chromatographic conditions: using HypersilDs chromatographic column; mobile phase: acetonitrile-water ratio of 30:70; detection wavelength: 200nm; column temperature: 20°C; flow rate: 1.0mL min -1 ;Injection volume: 10μL;

[0223] (2) Preparation of reference substance solution: Accurately weigh an appropriate amount of asiaticoside reference substance dried at 80°C to constant weight, ...

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Abstract

The invention belongs to the field of traditional Chinese medicine, provides a medicine composition for treating rhinitis and discloses a medicine composition for treating rhinitis, a preparation method thereof and a quality inspection method. The medicine composition is prepared from, by weight, 1-2 parts of cypress fruits, 1-2 parts of microsorium fortunei ching, 1-2 parts of thyrocarpus glochidiatus and 1-2 parts of panax notoginseng. The medicine composition is prepared into nose drops through a conventional pharmaceutical method in traditional Chinese medicine pharmacology. The method for measuring the content of asiaticoside through efficient liquid phase chromatography is provided and a method for measuring the content of ageratum conyzoides chromene and coumarin through gas chromatography is further provided. The medicine composition can be used for preparing medicine for treating rhinitis, allergic rhinitis and chronic hypertrophic rhinitis.

Description

[0001] Technical field: [0002] The invention belongs to the field of traditional Chinese medicines, and relates to a pharmaceutical composition for treating rhinitis, in particular to a pharmaceutical composition prepared from cypress fruit, domino grass, shield fruit grass and bell bell notoginseng as raw materials. [0003] Background technique: [0004] With the continuous acceleration of the global industrialization process and the impact of environmental pollution and other factors, the incidence of global respiratory diseases has increased rapidly. The incidence of allergic rhinitis (Allergic Rhinitis, AR) tends to increase gradually. Because of the high incidence of allergic rhinitis, its close relationship with allergic asthma, and its serious impact on people's quality of life, research on its etiology, pathogenesis, diagnosis, and treatment has received unprecedented attention. According to a comprehensive report published by 31 member countries of the Internationa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/30A61P11/02A61P37/08G01N30/02
CPCA61K36/11A61K36/14A61K36/185A61K36/30A61K2236/331A61K2236/39G01N30/02G01N2030/025G01N2030/027A61K2300/00
Inventor 佟雷高月娟刘金丽曹艳丽赵玉梅潘艳明于凤波侯甲福张秀萍孙琳林
Owner MUDANJIANG MEDICAL UNIV
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