Traditional Chinese medicine compound composition with anti-pulmonary fibrosis effect and its preparation method and application

Abstract

The invention discloses a traditional Chinese medicine composition with a function of pulmonary fibrosis resistance and a preparation method of the traditional Chinese medicine composition with the function of pulmonary fibrosis resistance. The traditional Chinese medicine composition with the function of pulmonary fibrosis resistance is prepared from, by weight, 2-10 parts of Radix Ginseng, 2-20 parts of Cortex Mori, 2-20 parts of Cortex Lycii, 1-10 parts of Radix Glycyrrhizae, 2-20 parts of Rhizoma Anemarrhenae, 2-20 parts of Exocarpium Citri Rubrum, 2-20 parts of Radix Asparagi and 2-20 parts of Radix Salviae Miltiorrhizae. The traditional Chinese medicine composition is prepared by matching of traditional Chinese medicines through a large amount of experiments according to syndrome differentiation and treatment theories and traditional Chinese medicine theories. According to experimental results, the traditional Chinese medicine composition has remarkable functions of alleviating pulmonary fibrosis and other pulmonary lesions caused by bleomycin and improving pulmonary functions and is capable of remarkably lowering pulmonary fibrosis closely related biological indicators such as pulmonary hydroxyproline content and bronchoalveolar lavage fluid PDGF, NF-kB, TNF-alph and IFNgamma levels and reducing pulmonary tissue TGFbeta, Smad3mRNA and protein expression. Furthermore, the traditional Chinese medicine composition with the function of pulmonary fibrosis resistance can be used for treatment of various idiopathic and secondary pulmonary fibrosis and has significant social benefits and economic benefits.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine compound composition with an anti-pulmonary fibrosis effect and a preparation method and application thereof, which belong to the technical field of traditional Chinese medicine. Background technique [0002] Interstitial lung disease is based on diffuse lung parenchyma, alveolar inflammation and interstitial fibrosis. In recent years, with the increasingly serious problem of air pollution, the prevalence of respiratory diseases has increased year by year, and the incidence of interstitial lung diseases has also shown a significant increase trend, especially among them, idiopathic pulmonary interstitial fibrosis is a clinically refractory disease. One of the diseases, the lung function of most patients gradually deteriorates within a few years, and the condition is dangerous, especially posing a greater threat to the health of the elderl...

AI Technical Summary

Problems solved by technology

In terms of treatment, glucocorticoids, immunosuppressants / cytotoxic drugs and anti-fibrosis agents are commonly used in clinical treatment, but there are obvious side effects and the curative effect is not ideal

This disease not only brings great pain to the patients, but also greatly affects the quality of life, even threatens the lives of the patients, and also brings a heavy economic burden to the society.

Traditional Chinese medicine has summed up systematic theories and accumulated rich experience in prescriptions and medications in the course of fighting against diseases for more than 2,000 years. However, there are still few reports on the effects and mechanisms of compound prescriptions for pulmonary fibrosis. In-depth exploration and research, there is a big gap with the actual needs of the majority of patients

[0003] The traditional Chinese medicine compound composition involved in the present invention, ginseng nourishes qi and nourishes the lungs, Morus alba and Digupi clear latent heat in the lungs, Radix Asparagus and Anemarrhena nourishes yin and moistens dryness, orange red regulates qi and eliminates phlegm, salvia miltiorrhiza clears collaterals and removes blood stasis, licorice In clinical application, it can improve lung function, significantly relieve clinical symptoms such as cough, shortness of breath, and cyanosis in patients with pulmonary fibrosis, control the development of the disease, and improve the quality of life. Reports on fibrosis drugs

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