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Method for measuring semi-volatile substances in mainstream smoke of cigarettes

A cigarette mainstream smoke and semi-volatile technology, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of accurate quantitative influence, low recovery rate of target objects, etc., to ensure accuracy, reduce errors, and achieve good linear correlation sexual effect

Inactive Publication Date: 2016-05-11
CHINA TOBACCO JIANGSU INDAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, when using GC-MS for analysis, due to the influence of the complex matrix of the flue gas, it is limited to a low level of semi-volatile substances in the flue gas, and the deuterated internal standards of pyridine and quinoline are easy to co-elute with interfering substances. The recovery rate of the target substance is low, which affects the accurate quantification

Method used

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  • Method for measuring semi-volatile substances in mainstream smoke of cigarettes
  • Method for measuring semi-volatile substances in mainstream smoke of cigarettes
  • Method for measuring semi-volatile substances in mainstream smoke of cigarettes

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Experimental program
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Effect test

preparation example Construction

[0048] (1) Preparation of internal standard solution: with D5-pyridine, D8-styrene and D7-quinoline as internal standards, using a volume concentration of 1% ammonia-methanol solution (hereinafter referred to as absorption solution) as a solvent, prepare Internal standard solution.

[0049] (2) Preparation of standard working solution: take pyridine, styrene and quinoline standard as target, use absorption solution as solvent, prepare standard stock solution through stepwise dilution, and then add a certain amount of internal standard solution respectively to prepare into a standard working solution.

[0050] (3) Preparation of sample solution: collect the target substance in cigarette smoke, accurately add a certain amount of internal standard solution and a certain volume of absorption solution, shake and extract, and pass the purified solution through an organic filter to obtain a sample solution.

[0051] (4) Gas chromatography-tandem mass spectrometry analysis: the stand...

Embodiment 1

[0071] The present embodiment is as follows to the detection method of the semivolatile substance pyridine, styrene and quinoline in cigarette mainstream smoke (the flow chart of described detection method is as follows figure 1 shown):

[0072] (1) Preparation of internal standard solution

[0073] ①Internal standard stock solution: Accurately weigh 0.1011gD5-pyridine, 0.0515gD8-styrene and 0.0052gD7-quinoline in a 100mL volumetric flask, dissolve with 1% ammonia-methanol solution and adjust the volume to the mark . ②Internal standard solution: Accurately pipette 0.4mL of internal standard stock solution, put it in a 100mL volumetric flask, dilute it with 1% ammonia-methanol solution and bring the volume up to the mark. The concentrations of D5-pyridine, D8-styrene and D7-quinoline were 4.044μg / mL, 2.06μg / mL and 0.208μg / mL, respectively.

[0074] (2) Preparation of standard working solution

[0075] ① Primary standard stock solution: Accurately weigh 0.5172g of pyridine, ...

Embodiment 2

[0102] The present embodiment is as follows to the detection method of the precision of the present invention and the standard addition recovery rate:

[0103] Taking a cigarette sample as the analysis object, the intraday precision experiment was carried out respectively. In the intraday precision experiment, the same sample was measured in parallel 6 times under the same conditions (same batch processing), and the relative standard deviation of the 6 parallel determination results were calculated respectively ( RSD), the results are shown in Table 4 below. The results in the table show that the intraday repeatability of this experimental method is RSD<6%, which indicates that the method has good precision for the quantitative analysis of trace substances.

[0104] The precision results of the method in Table 4

[0105]

[0106]

[0107] Taking the cigarette sample used in the repeatability test as the analysis object, the cigarette is normally smoked, and after the sm...

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Abstract

The invention discloses a method for measuring semi-volatile substances in mainstream smoke of cigarettes, and in particular relates to a chromatography-tandem mass spectrometry based method for determining contents of three semi-volatile substances, pyridine, styrene and quinoline, in the mainstream smoke of cigarettes. The method includes preparation an internal standard solution, a standard solution and a sample solution, analysis by gas chromatography-tandem mass spectrometry, and calculation of measured results. The method uses the respective deuterated substances of the objects as the internal standard substances for quantification, has the advantages of simpleness, sensitive response and accurate quantitative analysis, and effectively reduces the interference caused by the complex matrix of a sample. The conditions of the employed analytical instrument endow good signal response on the objects, and have good linear correlation. The method has high sensitivity and good reproducibility and recovery, and is applicable to quantitative analysis of trace objects in complex matrices of mainstream smoke.

Description

technical field [0001] The invention relates to a method for measuring semivolatile substances in cigarette mainstream smoke, belonging to the technical field of cigarette physical and chemical index detection. Background technique [0002] Semi-volatile substances are an important part of cigarette smoke, and they are distributed in the particulate phase and gaseous phase of mainstream smoke. Among them, pyridine, styrene and quinoline are the most concerned semi-volatile organic compounds, which are listed in the Hoffman list And the important chemical ingredients in the Canadian government's detection list. In addition, pyridine, styrene and quinoline are also one of the chemical components of concern stipulated by the US Environmental Protection Agency (EPA), and the Canadian government also regards these three substances as controlled components of tobacco products and chemical components that must be disclosed. With the in-depth understanding of the toxicity of these ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N30/88
CPCG01N30/88G01N2030/8809
Inventor 廖惠云庄亚东王晨辉韩开冬熊晓敏石怀刘献军王珂清李朝建张媛尤晓娟朱莹
Owner CHINA TOBACCO JIANGSU INDAL
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