Compositions for treating skin thickening
A skin, skin area technology, applied in the direction of preparations for skin care, skin diseases, pharmaceutical formulations, etc., which can solve problems such as increased skin thickness and risk of other skin abnormalities or symptoms
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Embodiment 1
[0085] Embodiment 1 water-soluble external preparation
[0086] This example describes water-soluble topical formulations that can be used in the present invention.
[0087] The first aqueous topical formulation comprises: Brimonidine tartrate (0.01%-5% w / w); Puriteg (0.005% w / w) (stabilized chlorine dioxide) as a preservative; and inactive ingredients: boric acid , calcium chloride, magnesium chloride, potassium chloride, pure water, sodium borate, sodium carboxymethylcellulose, sodium chloride; adjust the pH to 5.6-6.6 with hydrochloric acid and / or sodium hydroxide. Osmolality is in the range of 250-350 Osmol / kg.
[0088] The second aqueous topical formulation comprises: brimonidine tartrate (0.2%-2% w / w); benzalkonium chloride (0.005% w / w.) as a preservative; and inactive ingredients: boric acid, calcium chloride , magnesium chloride, potassium chloride, pure water, sodium borate, sodium carboxymethylcellulose, sodium chloride; adjust the pH to 5.6-6.6 with hydrochloric a...
Embodiment 2
[0089] Embodiment 2 cream or ointment external preparation
[0090] This example describes cream or ointment topical formulations that can be used in the present invention.
[0091] The first cream formulation for external use (hydrophilic ointment) is as described in Table 2.
[0092] Table 2
[0093]
[0094]
[0095] Note to the fit: To prepare the formulation, melt the stearyl alcohol and white petrolatum on a steam bath and heat to 75°C. The other components previously dissolved in water and heated to 75°C were added and the resulting mixture was stirred until solidified. The resulting mixture was then cooled and stirred before adding brimonidine tartrate as a concentrated solution.
[0096] Ointment external preparation (hydrophilic ointment) is as described in Table 3.
[0097] table 3
[0098] components
[0099] To prepare the formulation, stearyl alcohol and white wax are mixed together on a steam bath. Then add the cholesterol and stir until it...
Embodiment 3
[0100] Embodiment 3 gel preparation for external use
[0101] This example describes gel topical formulations that can be used in the present invention.
[0102] The first gel formulation is described in Table 4.
[0103] Table 4
[0104] components
weight%
Brimonidine tartrate
0.01–5％
Methylparaben NF
0.15％
Propylparaben NF
0.03％
Carboxyethyl cellulose NF
1.25％
Edetate Disodium USP
0.05％
Pure water, USP
Appropriate amount
total
100％
[0105] The second gel formulation is described in Table 5.
[0106] table 5
[0107] components
weight%
Brimonidine tartrate
0.5％
Methylparaben
0.20％
Propylparaben
0.05％
Carbomer 934P NF
1.0％
sodium hydroxide
Appropriate amount, pH 7
Pure water, USP
Appropriate amount
total
100％
[0108] All components were mixed to...
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