Preparation method of terpenoid and lignan substances in eucommia ulmoides bark or eucommia ulmoides leaves and application of terpenoid and lignan substances in preparation of senile dementia treatment drug

A technology of lignans and Eucommia leaves, applied in the preparation of organic compounds, preparation of sugar derivatives, chemical instruments and methods, etc.

Active Publication Date: 2016-05-18
张忠立
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned studies have not been reported yet. Through systematic in vivo and in vitro experimental studies, we first found that Eucommia bark or Eucommia leaves have effects on aging, cardiovascular and cerebrovascular diseases (heart disease, hypertension, atherosclerosis and transient ischemic attack, etc.) It has a good therapeutic effect on senile dementia and Alzheimer's disease that lead to cerebral hypoperfusion state and the etiology of amyloid Aβ deposition

Method used

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  • Preparation method of terpenoid and lignan substances in eucommia ulmoides bark or eucommia ulmoides leaves and application of terpenoid and lignan substances in preparation of senile dementia treatment drug
  • Preparation method of terpenoid and lignan substances in eucommia ulmoides bark or eucommia ulmoides leaves and application of terpenoid and lignan substances in preparation of senile dementia treatment drug
  • Preparation method of terpenoid and lignan substances in eucommia ulmoides bark or eucommia ulmoides leaves and application of terpenoid and lignan substances in preparation of senile dementia treatment drug

Examples

Experimental program
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Effect test

Embodiment 1

[0036] Eucommia bark or eucommia leaf terpenes in monoterpene eucommia alcohols Eucommia alcohol (eucommiol), 1-deoxyeucommiol (1-deoxyeucommiol), 1-deoxy-△4,5-eucommia alcohol (1-deoxy-△ 4,5-eucommiol), 2,3-dihydroxy-△4,5-eucommia alcohol (2,3-dihydroxyl-△4,5-eucommiol), 4′-acetyl-eucommia alcohol (4′-acetyl- eucommiol) and Eucommia glycoside A (5-hydroxyl-3,4-dihydroxymethyl-2-hydroxyethyl-cyclohex-1-enone-2″-O-β-D-glucopyranoside), wherein: Eucommia bark or Eucommia The leaf herbs are crushed into coarse powder, soaked in 60% ethanol for 1 hour, 8 times the amount of solvent is heated and refluxed for 3 times, each time for 2 hours, filtered, and the filtrates are combined. The above filtrate is concentrated under reduced pressure at 65 °C to 1.0 g raw herbs / ml , refrigerated overnight at 0-4°C, separated gel, centrifugally filtered, enriched with AB-8 macroporous adsorption resin on the filtrate, eluted with water, 25% ethanol, 40% ethanol, 60% ethanol and 95% ethanol was...

Embodiment 2

[0038] Eucommia bark or eucommia leaf terpenes in monoterpene eucommia alcohols Eucommia alcohol (eucommiol), 1-deoxyeucommiol (1-deoxyeucommiol), 1-deoxy-△4,5-eucommia alcohol (1-deoxy-△ 4,5-eucommiol), 2,3-dihydroxy-△4,5-eucommia alcohol (2,3-dihydroxyl-△4,5-eucommiol), 4′-acetyl-eucommia alcohol (4′-acetyl- eucommiol) and eucommia glycoside A (5-hydroxyl-3,4-dihydroxymethyl-2-hydroxyethyl-cyclohex-1-enone-2″-O-β-D-glucopyranosi-de).

[0039]

[0040]

[0041] Eucommia alcohol (1-deoxyeucommiol) colorless oil, molecular formula is C 9 h 16 o 4 ,ESI-MSm / z[M+H] + 189. 1 H-NMR (DMSO-d 6 , 400MHz) δ: 3.88 (1H, m, H-1), 2.52 (1H, m, H-2), 2.15 (1H, dd, J=3.2, 16.4Hz, H-5a), 2.58 (1H, dd , J=6.8, 16.4Hz, H-5b), 1.28(1H, m, H-2′a), 1.77(1H, m, H-2′b), 3.85(1H, d, J=12.5Hz, H-3'a), 4.06 (1H, d, J=12.5Hz, H-3'b), 3.97 (2H, t, H-2"), 3.47 (2H, q, H-4'); 13 C-NMR (DMSO-d 6 , 100MHz) δ: 74.8 (C-1), 52.6 (C-2), 135.4 (C-3), 137.5 (C-4), 42.3 (C-5), 34.2 (C-2′), 55.3 ( C-3...

Embodiment 3

[0048] Eucommia bark or eucommia leaf terpenoids in sesquiterpene macropilanes Eucommia phylloside A is (6R,7E,9R)-megastigma-4,7-dien-3-one-9-O-[β- D-xylopyranos-yl-(1″→6′)-β-D-glucopyranoside], eucommia leaf glycoside B is (6S,7E,9R)-megastigma-4,7-dien-3-one-9-O- [β-D-xylopyranos-yl-(1″→6′)-β-D-glucopyranoside], eucommia leaf glycoside C is (6S,9R)-megastigmane-4-ene-3-one-9-O-[ β-D-xylopyranosyl-(1″→6′)-β-D-glucopyranoside], eucommia leaf glycoside D is (6S,9S)-megastigmane-4-ene-3-one-9-O-[β-D -xylopyranosyl-(1″→6′)-β-D-glucopyranoside], wherein: Eucommia ulmoides bark or eucommia leaves medicinal materials are pulverized into coarse powder, soaked in 60% ethanol for 1 hour, and 8 times the amount of solvent is heated and refluxed for extraction 3 times, 2 hours each time, filter, and combine the filtrates. The above filtrate was concentrated under reduced pressure at 65°C to 1.0g raw medicinal materials / ml, refrigerated overnight at 0-4°C, gelatinized, centrifugally fi...

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Abstract

The invention relates to a preparation method of terpenoid and lignan substances in eucommia ulmoides bark or eucommia ulmoides leaves and an application of the terpenoid and lignan substances in preparation of senile dementia and AD (Alzheimer disease) treatment drugs or healthcare food. The prepared terpenoid substance in the eucommia ulmoides bark or the eucommia ulmoides leaves is one or more of 1-deoxy-delta4,5-eucommiol, 2,3-dyhydroxyl-delta4,5-eucommiol, 5-hydroxyl-3,4-dihydroxymethyl-2-hydroxyethyl-cyclohex- 1-enone-2'-O-beta-D-glucopyranoside), (6R, 7E, 9R)-megastigma-4,7-dien-3-one-9-O-[beta-D-xylopyranos-yl-(1'-6')-beta-D-glucopyranoside, (6S, 7E, 9R)-megastigma-4,7-dien-3-one-9-O-[beta-D-xylopyranos-yl-(1'-6')-beta-D-glucopyranoside] and the like. The prepared lignan substance in the eucommia ulmoides bark or the eucommia ulmoides leaves is one or more of pinoresinol-4,4'-O-beta-D-bis(glucopyranoside), 8-hydroxyl-pinoresinol-4'-O-beta-D-glucopyranoside, lariciresinol-4,4'-O-beta-D- bis(glucopyranoside) and the like. The terpenoid and lignan substances have common or similar structural units such as eucommiol, megastigmane sesquiterpene, bisepoxylignans, single-epoxy lignans and the like, thereby having the similar treatment effect in a human body.

Description

technical field [0001] The invention relates to a preparation method of terpenoids and lignans in eucommia bark or eucommia leaves and its application in the preparation of medicines or health food for treating senile dementia and Alzheimer's disease, and belongs to the technical field of traditional Chinese medicine preparation. Background technique [0002] Eucommia bark is the dry bark of Eucommiaulmoides Oliv., a plant of the family Eucommia ulmoides. It is sweet, slightly pungent, warm in nature, and returns to the liver and kidney channels. Modern research on Eucommia bark proves that Eucommia has multiple effects such as two-way regulation of blood pressure, enhancement of immunity, anti-tumor, anti-oxidation, anti-virus, anti-aging, lowering blood sugar, and regulating blood lipids. Eucommia ulmoides leaves are the dried leaves of Eucommia ulmoides Oliv., which was included in the Chinese Pharmacopoeia as a new medicinal material in 2005. It is warm in nature and sli...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/047A61K31/7032A61K31/22A61K31/7048C07C35/06C07C29/76C07H15/18C07H1/08C07C67/56C07C69/21C07H17/04C07H15/26A23L33/10A23L33/105A61P25/28
CPCA23V2002/00A61K31/047A61K31/22A61K31/7032A61K31/7048C07C29/76C07C67/56C07H1/08C07H15/18C07H15/26C07H17/04C07C35/06C07C69/21A23V2200/30A23V2250/21
Inventor 张忠立左月明
Owner 张忠立
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