Novel application of itraconazole

A technology of itraconazole and its use, which is applied in the new application field of itraconazole to achieve the effect of inhibiting the proliferation and migration of endothelial cells and good medicinal value

Active Publication Date: 2016-06-08
WEST CHINA HOSPITAL SICHUAN UNIV
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AI Technical Summary

Problems solved by technology

[0008] So far, there is no information about the use of itraconazole as the active ingredient, or the pharmaceutical composition containing itraconazole, for the treatment of hemangiomas, especially infantile hemangiomas, hemangioendotheliomas, hemangioperictheliom

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  • Novel application of itraconazole
  • Novel application of itraconazole
  • Novel application of itraconazole

Examples

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Embodiment Construction

[0043] The experimental methods described in the following examples, unless otherwise specified, are conventional methods; the reagents and materials, unless otherwise specified, can be obtained from commercial sources.

[0044] 1. Observation on the clinical efficacy of itraconazole in the treatment of infantile hemangioma

[0045] On November 23, 2011, the inventor encountered a 2-month-old baby girl (weight 4kg) in the dermatology clinic, who went to the doctor 10 days after birth due to hemangioma and ulcer formation between the left buttock and thigh. figure 1 -A shown. Fungal hyphae were found by direct microscopic examination of the secretions on the surface of the ulcer, and yeast-like colonies were grown by culture. It was identified as Candida albicans by CHROMagar color culture and molecular biology (using ITS1 / 4 primers for PCR amplification and product sequence analysis) (Candidaalbicans, GenBank accession number KC176533), diagnosed as infantile hemangioma ulcer...

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Abstract

The invention belongs to the field of medicine, specifically relates to an novel application of itraconazole, and provides a novel application of itraconazole in the preparation of drugs for treating hemangioma. Itraconazole can effectively inhibit the proliferation and migration performance of endothelial cells of hemangioma, has a good pharmaceutical value, can be used to treat hemangioma in clinic especially strawberry hemangioma, cavernous hemangioma, plexiform hemangioma, verrucous hemangioma, and mixed hemangioma, and can also treat hemangioma of each organ such as liver hemangioma, spleen hemangioma, brain hemangioma, and the like. A novel choice is provided for treating diseases of blood vessel excessive proliferation and blood vessel malignant proliferation, such as hemangioendothelioma, hemangiopericytoma, glomangioma, hemangiosarcoma, angiofibroma, angiolipoma, angiokeratoma, spider nevus, vascular malformation, telangiectasis, infantile hemangioma, adult hemangioma, senile hemangioma, Kaposi's sarcoma, and the like.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to a new application of itraconazole. Background technique [0002] Itraconazole is a synthetic high-efficiency, broad-spectrum, oral (capsule and oral liquid) or intravenous (injection) triazole antifungal drug. Formula -4-[4-[4-[4-[[2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazole-1-methyl)-1, 3-dioxolan-4-yl]methoxy]phenyl]-1-piperazine]phenyl]-2,4-dihydro-2-(1-methylpropyl)-3H-1, 2,4-Triazol-3-one, the molecular formula is C 35 h 38 Cl 2 N 8 0 4 , molecular weight: 705.64, CAS number: 84625-61-6. Itraconazole capsule preparation is off-white pellet-like granules; odorless and tasteless; itraconazole oral liquid preparation is light yellow or yellow viscous clear liquid with cherry flavor. Itraconazole injection is a colorless to slightly yellow clear liquid. This product is soluble in lipids and almost insoluble in water. The molecular structure of itraconazole is as fol...

Claims

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Application Information

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IPC IPC(8): A61K31/496A61P35/00A61P35/04
CPCA61K31/496A61K9/06A61K9/08A61K9/14A61K9/20A61K9/48
Inventor 冉玉平
Owner WEST CHINA HOSPITAL SICHUAN UNIV
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