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Targeting photodynamics treatment-chemotherapy integrated nanocompound and application thereof

A photodynamic therapy and nano-compound technology, applied in the field of biomedicine, can solve problems such as difficult to achieve curative effect, achieve the effect of reducing systemic side effects and low development cost

Inactive Publication Date: 2016-06-15
SOUTHEAST UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Various existing treatment methods such as surgery, chemotherapy, radiotherapy, and biological therapy have certain limitations. It is difficult to achieve the desired curative effect by relying solely on a certain treatment method. The advantages of treatment methods, synergistic effects, obtaining curative effects that cannot be obtained by single treatment methods, and comprehensive tumor treatment to achieve better therapeutic effects have become consensus and basic principles

Method used

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  • Targeting photodynamics treatment-chemotherapy integrated nanocompound and application thereof
  • Targeting photodynamics treatment-chemotherapy integrated nanocompound and application thereof
  • Targeting photodynamics treatment-chemotherapy integrated nanocompound and application thereof

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Embodiment 1

[0022] The targeted photodynamic therapy and chemotherapy integrated nano-medicine for treating tumors and the preparation method of the present invention use core-shell structure Fe 3 o 4 ZnO nanocomposites are used as carriers, and anthracycline anti-tumor drugs are loaded on the carrier surface to construct a drug delivery system, and the drug loading and Fe 3 o 4 ZnO is related to the weight ratio of anthracyclines, and in Fe 3 o 4 The weight of ZnO and anthracycline antineoplastic drugs is relatively small, with Fe 3 o 4 The weight ratio of ZnO to anthracyclines increases, 5:1 is 13.79±1.25%, 5:2 is 19.71±2.23%, and Fe 3 o 4 The increase in the weight ratio of ZnO to anthracyclines increases the drug loading is no longer obvious, reaching a saturated state, therefore, Fe 3 o 4 The optimal weight ratio of ZnO to anthracycline antineoplastic drugs is 5:2. The anthracycline antineoplastic drugs refer to antineoplastic drugs such as adriamycin and daunorubicin.

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Abstract

The invention relates to a targeting photodynamics treatment-chemotherapy integrated nanocompound and application thereof. The drug is formed by reacting Fe3O4@ZnO with an antharcycline compound through chelating, wherein a weight ratio of the Fe3O4@ZnO to the antharcycline compound is 5 to 2. A nano medicine ZnO component and the antharcycline antitumor drug establish a drug transmission system by chelating reaction, the Fe3O4 component mediates the targeted drug transmission system magnetically, the drug concentration in tumor tissue and cells can be obviously improved, and whole body toxic and side effects can be reduced; tumor cells can be attacked again by the ZnO component by means of the mediated photodynamics treatment, and the antitumor effect and targeting killing action of the antitumor drug can be improved.

Description

technical field [0001] The invention relates to the technical field of biomedicine, and relates to a method for preparing a nanomedicine integrating targeted photodynamic therapy and chemotherapy for treating tumors. Background technique [0002] Malignant tumors seriously threaten people's health. Various existing treatment methods such as surgery, chemotherapy, radiotherapy, and biological therapy have certain limitations. It is difficult to achieve the desired curative effect by relying solely on a certain treatment method. The advantages of treatment methods, synergistic effects, obtaining curative effects that cannot be obtained by single treatment methods, and comprehensive tumor treatment to achieve better therapeutic effects have become consensus and basic principles. Therefore, the multimodal combination therapy system is still the main direction to improve the level of tumor treatment. [0003] Nanomedicine is a cutting-edge interdisciplinary science covering che...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K41/00A61K31/704A61K47/48A61K9/19A61K9/00A61K47/04A61P35/00
CPCA61K41/0052A61K9/0019A61K9/19A61K31/704A61K47/02A61K2300/00
Inventor 张海军陈宝安王西勇王彩莲熊健丁双
Owner SOUTHEAST UNIV
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