Metal grating surface plasma effect biological-detection chip for THz-TDS system

A surface plasmon and metal grating technology is applied in the field of terahertz time-domain spectral detection, which can solve the problems of high difficulty in construction and operation, and achieve the effects of fast detection speed, simple operation and high detection accuracy

Inactive Publication Date: 2016-06-15
CAPITAL NORMAL UNIVERSITY
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Problems solved by technology

Because the depth of entering the medium is very short, the strong absorption of THz by water is reduced, and the measurement accuracy is high. However, the system mostly uses oblique reflection system for measurement, and the system construction and operation are difficult.

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  • Metal grating surface plasma effect biological-detection chip for THz-TDS system
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  • Metal grating surface plasma effect biological-detection chip for THz-TDS system

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Embodiment Construction

[0027] The present invention will be described in detail below with reference to the accompanying drawings and examples.

[0028] The technical problem to be solved by the present invention is to provide a reusable and highly transplantable biochemical aqueous solution sample chip detected by terahertz waves. Each part of the chip is independent of each other and can be used as required. Using the surface plasmon enhancement effect of the metal grating 2 and the traditional THz-TDS system, the operation is relatively simple. This technology does not require marking, and has high detection speed and high detection accuracy. The surface plasmon enhancement effect of the metal grating 2 is similar to the surface plasmon resonance coupled with the prism. It uses the periodic structure of the grating to generate evanescent waves. Since the evanescent waves are sensitive to small changes in the surrounding environment, the refractive index and There is a difference in the absorptio...

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Abstract

The invention discloses a metal grating surface plasma effect biological-detection chip for a THz-TDS system.The metal grating surface plasma effect biological-detection chip is economical and practical and free of marking and has the advantages of high detection speed and high detection precision.As biological aqueous samples are detected according to resonance peaks of SPR (Surface Plasmon Resonance), humidity requirements to detection environment is lower than that of the way of directly transmitting the samples according to conventional terahertz time-domain spectroscopy.With the open type design, the chip can be reused since different parts thereof can be detached and cleaned.The metal grating can be made of aluminum so that mass production with high economical efficiency and practicability can be achieved.Since the samples do not need to be marked, use of special equipment for adding samples is avoided, and only tiny injectors are needed in use, and accordingly operation is simplified.

Description

technical field [0001] The invention belongs to the technical field of terahertz time-domain spectrum detection, and in particular relates to a metal grating surface plasma effect biological detection chip used in a THz-TDS system. Background technique [0002] Terahertz detection technology is developing more and more rapidly, and it involves more and more fields, such as: safety detection, imaging technology, medical diagnosis, and plant classification. We know that many biomolecules and chemical substances exhibit absorption and dispersion characteristics in the terahertz wave frequency band due to vibrational transitions, and THz spectroscopy technology is very sensitive to the detection of small differences and changes in substances and the biochemical environment in which they live, and has the ability to reflect The "fingerprint" feature of the compound structure, so THz spectroscopy has been more and more researched in biomedicine in recent years, and is applied to s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/3586
CPCG01N21/3586
Inventor 吴英苏波张存林
Owner CAPITAL NORMAL UNIVERSITY
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