Polypeptide, detection device containing polypeptide and detection kit containing device

A technology for detection kits and devices, which is applied in the field of detection kits, early screening and clinical auxiliary diagnosis of peptides, and can solve problems such as unsuitable for on-site measurement and long detection time

Inactive Publication Date: 2016-07-06
SUZHOU SJ BIOMATERIALS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] The detection of enterovirus type 71 (IgM) on the market mostly uses enzyme-linked immunoassay kits, but although the detection limit of the kit is low (0.15mg / L), the detection time is long and it is not suitable for on-site determination. Chinese patent application Invention patent application No. 201010171862.2, a diagnostic kit (enzyme-linked immunoassay) for enterovirus 71 antibody (IgM) is proposed, which needs to be tested before and after the detection of enterovirus 71 antibody (IgM). The instrument cleaning and maintenance work requires a long detection time, and requires professional and technical personnel in the field to operate

Method used

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  • Polypeptide, detection device containing polypeptide and detection kit containing device
  • Polypeptide, detection device containing polypeptide and detection kit containing device
  • Polypeptide, detection device containing polypeptide and detection kit containing device

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Embodiment

[0065] Hereinafter, the present invention will be described more specifically through examples, but the technical scope of the present invention is not limited. Through the description of this specification, those skilled in the art can easily modify / change the present invention, and these are included in the technical scope of the present invention. The scope of the invention is determined by the claims.

[0066] 1. Peptide preparation and confirmation

[0067] The polypeptide used in the examples has the amino acid sequence shown in SEQ ID NO: 1, and was synthesized by Shanghai Jier Biochemical Co., Ltd. The characterization of the polypeptide can confirm that the polypeptide was synthesized by hydrogen spectrum and mass spectrum. Liquid chromatography detection purity: 96.85% (area normalization method): mass spectrometry detection (ESI-MS): calculated molecular weight: 2373.72, test value 2372.76.

[0068] 2. Fabrication of Detection Devices

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Abstract

The invention relates to a polypeptide, a detection device containing the polypeptide and a diagnostic kit containing the detection device. The polypeptide, the detection device containing the polypeptide and the diagnostic kit containing the detection device provided by the invention are applied in early screening and clinical auxiliary diagnosis of human enterovirus 71, and satisfying effects can be obtained.

Description

technical field [0001] The invention belongs to the field of biological detection, in particular to a polypeptide that can be used for early screening and clinical auxiliary diagnosis of enterovirus 71, and a detection kit of a detection device containing the polypeptide. Background technique [0002] Enterovirus type 71 IgM belongs to enterovirus type A. Enteroviruses are generally named by numbers, and the order of arrangement represents the order in which they were discovered. In order, this virus is named enterovirus 71 (Humanenterovirus 71), referred to as EV71, which is one of the main pathogens causing hand-foot-and-mouth disease (HFMD) in infants. Human enterovirus 71 was first isolated in 1969 from fecal samples of infants with central nervous system disease in California. [0003] EV71 mainly causes hand, foot and mouth disease, and can also cause various neurological diseases such as aseptic meningitis, brainstem encephalitis and polio-like paralysis. Hand, foot...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K7/08G01N33/68G01N33/569
Inventor 马雄明
Owner SUZHOU SJ BIOMATERIALS
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