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Preparation method of andrographis paniculata freeze-dried preparation

A freeze-dried preparation, the technology of Chuanxinlian, which is applied in the field of preparation of the freeze-dried preparation of the extract of the traditional Chinese medicine Chuanxinlian, can solve problems such as adverse reactions, affecting clarity, and complex components

Inactive Publication Date: 2016-08-24
SHENYANG VICA ANIMAL HUSBANDRY TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, due to the complex composition of traditional Chinese medicine injections and the presence of active ingredients in the liquid, polymerization reactions between different components will occur after long-term storage, which will affect the clarity, or cause other adverse reactions. In order to solve this problem, we invented a Chuanxinlian lyophilized preparation

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0006] Example 1: Take 1000 g of Chuanxinlian, add 20 L, 18 L, and 18 L of 60% ethanol to reflux for extraction for 90 minutes, combine the filtrates, and recover the ethanol to make a liquid extract. Then add absolute ethanol to make the alcohol content reach 80%, let the liquid stand for a while, filter, add 1% activated carbon to the filtrate, and stir for 30 minutes. Perform the following operations on the ultra-clean workbench: first filter out activated carbon with sterilized filter paper, and now filter with a sterilized G4 funnel, recover ethanol from the filtrate and concentrate it to 350ml under reduced pressure; add an appropriate amount of solubilizer and mix well , add water for injection to make up to 500ml crude drug content, subpackage 2ml / bottle, add rubber stopper, freeze-dry in a freeze dryer, press cap, label, pack, and get ready.

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Abstract

The invention provides a preparation method of an andrographis paniculata freeze-dried preparation, which comprises the following steps: carrying out reflux extraction on the andrographis paniculata medicinal material respectively with 20-times, 18-times and 18-times 60% ethanol for three times, 90 minutes per time; mixing the extracting solutions; recovering ethanol to prepare fluid extract; adding ethanol to enable the ethanol content to reach 80%; standing over night; filtering; adding 1% of active carbon into the filtrate; stirring for 30 minutes; filtering with a sterilized G4 filter element under aseptic conditions; recovering ethanol from the filtrate, and carrying out vacuum concentration until the crude drug content is about 3g / ml; adding a right amount of solubilizing agent and uniformly mixing; adding water for injection for metering volume until the crude drug content is 2g / ml; sub-packaging; freeze-drying; covering; labeling; and packaging to obtain the andrographis paniculata freeze-dried preparation. The freeze-dried preparation can be preserved in a vacuum state, so that the stability of effective components can be obviously increased and the shelf life of the product can be prolonged.

Description

Technical field: [0001] The invention belongs to the field of traditional Chinese medicine preparations, and relates to a preparation method of a freeze-dried preparation of a traditional Chinese medicine Chuanxinlian extract, which can be used for preventing and treating animal diseases. Background technique: [0002] Andrographis paniculata is the dry aerial part of the Acanthaceae Andrographis plant, which is a traditional Chinese medicinal material in my country. It has the effects of clearing away heat and detoxification, reducing swelling and relieving pain, antibacterial, antiviral, antitumor, and anti-inflammatory. The whole plant can be used as medicine, and is known as "Chinese medicine antibiotics". Andrographis paniculata not only has a good curative effect, but also has abundant resources, fast absorption in the body, long drug effect, no obvious toxic and side effects, and has broad development prospects in veterinary clinics. According to reports, Andrographi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19A61K36/19A61P1/12A61P31/04A61P1/00A61P11/06A61P1/14A61P15/14A61P15/00
Inventor 王洪礼虞正伟赵宝凯
Owner SHENYANG VICA ANIMAL HUSBANDRY TECH
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