Medical composite chitosan gel containing analgesic drug

A chitosan gel, chitosan technology, applied in medical science, bandages, etc., can solve the problems of secondary wounds, easy adhesion of new tissues, damage to growth factors, etc., and achieve the effect of excellent performance

Inactive Publication Date: 2016-08-31
SICHUAN KUIXING MEDICAL POLYMER PROD CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Traditional dressings used on wounds mainly play an isolation and antibacterial role, but often lead to dryness of the wound, damage...

Method used

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  • Medical composite chitosan gel containing analgesic drug
  • Medical composite chitosan gel containing analgesic drug
  • Medical composite chitosan gel containing analgesic drug

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0047] Medical Composite Chitosan Gel Containing Analgesics - Amorphous Gel The prescription is:

[0048]

[0049] Preparation method: (1) Weigh the prescribed amount of glacial acetic acid, add purified water to prepare 1% glacial acetic acid solution, because chitosan can only be dissolved in weak acid, so use pH adjuster acetic acid to configure glacial acetic acid solution to dissolve Chitosan; (2) chitosan, hypromellose and glycerin are added in the above-mentioned 1% glacial acetic acid, and left to swell overnight; (3) lidocaine hydrochloride is dissolved with an appropriate amount of purified water, and added to In the gel formed in step (2), stir and mix evenly; (4) adjust the pH value of the gel to 4-7 with aqueous sodium hydroxide solution, make up the remaining amount of purified water, sterilize and pack, and obtain the medical compound Chitosan gel.

[0050] The prepared gel is suitable for acute incisions (such as: various surgical incisions, small debrideme...

Embodiment 2

[0052] Medical Composite Chitosan Gel Containing Analgesics - Amorphous Gel The prescription is:

[0053]

[0054] Preparation method: (1) take the prescription amount of carboxymethyl chitosan, carboxymethyl cellulose sodium and glycerin, add it into an appropriate amount of purified water, stir and mix, and place overnight; (2) weigh the prescription amount of lidocaine and Add prilocaine to the gel formed in step (1), stir and mix evenly; (3) adjust the pH value of the gel to 7-10 with hydrochloric acid / sodium hydroxide, make up purified water, let stand for defoaming, and extinguish Bacteria and packaging to obtain medical composite chitosan gel.

[0055] The prepared gel is suitable for acute incisions (such as: various surgical incisions, small debridement operations, small skin trauma and abrasions) and early painful chronic wounds with low and moderate exudates, and can provide moist healing Environment, inhibition of scar hyperplasia, physical isolation, autolytic...

Embodiment 3

[0057] Medical Composite Chitosan Gel Containing Analgesics - Amorphous Gel The prescription is:

[0058]

[0059]

[0060] Preparation method: (1) Add carboxymethyl chitosan, sodium alginate and glycerin in the prescribed amount into purified water, and leave to swell overnight; (2) Dissolve lidocaine hydrochloride in an appropriate amount of purified water, and add to the step ( 1) In the formed gel, stir and mix evenly; (3) Use sodium hydroxide / hydrochloric acid to adjust the pH value of the gel to 7-9, make up the remaining purified water, sterilize and pack to obtain the medical composite chitosan sugar gel.

[0061] The prepared gel is suitable for early acute wounds (such as: various surgical incisions, small debridement operations, small skin trauma and abrasions) and painful chronic wounds with low and moderate exudates, and can provide a moist healing environment , Inhibit scar hyperplasia, produce physical isolation, autolytic debridement and play an analgesi...

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PUM

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Abstract

The invention discloses medical composite chitosan gel containing analgesic drug. The medical composite chitosan gel is prepared from, by weight, 0.5-10 parts of chitosan high molecular materials, 0.5-7 parts of analgesic drug, 0-10 parts of thickening agent, 1-25 parts of moistening agent and 48-98 parts of purified water. The medical composite chitosan gel containing the analgesic drug can effectively keep the wet environment for a wound and relieve wound pain; according to the dressing, the chitosan high molecular materials are used as a matrix, the analgesic drug is adopted in an assisted mode, the advantages of moisture absorption, moisturizing, bacteriostasis, hemostasis and the like and the effect of analgesia of the analgesic drug are combined, and the gel with excellent performance is prepared.

Description

technical field [0001] The invention relates to the technical field of wound dressings, in particular to a medical composite chitosan gel containing analgesics. Background technique [0002] The skin and mucous membranes of the human body are the barriers to maintain the stability of the human body environment and prevent the invasion of microorganisms. Damage to the skin and mucous membranes caused by ulcers, trauma, burns and inflammation will cause a series of problems in the body, such as bacterial infection, increased metabolism, Excessive water and protein loss, endocrine and immune system dysfunction, etc., may be life-threatening in severe cases. When the skin and mucous membrane are injured, a suitable dressing should be selected to cover the wound. It can maintain a moist environment for the wound, absorb secretions, relieve pain and control bleeding, thereby promoting rapid wound healing. [0003] The use of dressings is an important means of maintaining a good w...

Claims

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Application Information

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IPC IPC(8): A61L26/00
CPCA61L26/0023A61L26/0066A61L2300/204A61L2300/402
Inventor 莫始奎
Owner SICHUAN KUIXING MEDICAL POLYMER PROD CO LTD
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